Platelet‐derived growth factor (PDGF) signalling in cancer: rapidly emerging signalling landscape

Platelet‐derived growth factor (PDGF)‐mediated signalling has emerged as one of the most extensively and deeply studied biological mechanism reported to be involved in regulation of growth and survival of different cell types. However, overwhelmingly increasing scientific evidence is also emphasizing on dysregulation of spatio‐temporally controlled PDGF‐induced signalling as a basis for cancer development. We partition this multi‐component review into recently developing understanding of dysregulation PDGF signalling in different cancers, how PDGF receptors are quantitatively controlled by microRNAs. Moreover, we also summarize most recent advancements in therapeutic targeting of PDGFR as evidenced by preclinical studies. Better understanding of the PDGF‐induced intracellular signalling in different cancers will be helpful in catalysing the transition from a segmented view of cancer biology to a conceptual continuum.     

DNA damage analysis concerning GSTM1 and GSTT1 gene polymorphism in gold jewellery workers from Peshawar Pakistan

Abstract

Purpose

To evaluate the genotoxic effects of gold jewellery fumes and its association with GSTM1 and GSTT1 genetic polymorphisms.     

Human MC4R variants affect endocytosis,trafficking and dimerization revealing multiple cellular mechanisms involved in weight regulation

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Characterization and Hazard Study of Two Areas of Penang Island,Malaysia

Penang Island of Malaysia is vulnerable to various natural hazards due to its hilly terrain and weather. Due to recent rapid population and economic growth, the probability of disaster associated with natural hazards has increased. This article characterizes geological and geotechnical parameters collected from field data that relate to natural hazard susceptibility. The areas of investigation were chosen so that each area lay on different geological formations. The variations in selected parameters with depth were obtained. The correlation within parameters was established and was found to be in agreement with that from other researchers. The investigation identifies parameters that can be used to evaluate the degree of hazard susceptibility.