排序方式: 共有179条查询结果,搜索用时 15 毫秒
171.
Johnathan Cooper-Knock Sai Zhang Kevin P. Kenna Tobias Moll John P. Franklin Samantha Allen Helia Ghahremani Nezhad Alfredo Iacoangeli Nancy Y. Yacovzada Chen Eitan Eran Hornstein Eran Elhaik Petra Celadova Daniel Bose Sali Farhan Simon Fishilevich Doron Lancet Karen E. Morrison Pamela J. Shaw 《Cell reports》2021,34(5):108730
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Asim Rizvi Mohd Farhan Imrana Naseem S. M. Hadi 《Apoptosis : an international journal on programmed cell death》2016,21(9):997-1007
Calcitriol is the metabolically active form of Vitamin D and is known to kill cancer cells. Using the rat model of DEN induced hepatocellular carcinoma we show that there is a marked increase in cellular levels of copper in hepatocellular carcinoma and that calcitriol–copper interaction leads to reactive oxygen species mediated DNA breakage selectively in hepatocellular carcinoma cells. In vivo studies show that calcitriol selectively induces severe fluctuations in cellular enzymatic and non enzymatic scavengers of reactive oxygen species in the malignant tissue. Lipid peroxidation, a well established marker of oxidative stress, was found to increase, and substantial cellular DNA breakage was observed. We propose that calcitriol is a proxidant in the cellular milieu of hepatocellular carcinoma cells, and this copper mediated prooxidant action of calcitriol causes selective DNA breakage in malignant cells, while sparing normal (non malignant) cells. 相似文献
175.
Ahmad Syed Farhan Jehangir Maryam Srikulnath Kornsorn Martins Cesar 《Reviews in Fish Biology and Fisheries》2022,32(2):357-385
Reviews in Fish Biology and Fisheries - The living fishes span a unique and interesting set of animals because of their vast diversity, morphology, ecology, genetics and genomics, and higher... 相似文献
176.
Farhan Khodaee Bahman Vahidi Nasser Fatouraee 《Biomechanics and modeling in mechanobiology》2016,15(5):1295-1305
Ischemic stroke is a major cause of death and long-term disabilities worldwide. In this paper, we aim to represent a comprehensive simulation of the motion of emboli through cerebrovascular network within patient-specific computational model. The model consists of major arteries of the circle of Willis reconstructed from magnetic resonance angiography images, pulsatile flow and emboli with different sizes and material properties. Here, the fluid–structure interactions method was used to simulate the motion of deformable and rigid emboli through cerebral arteries. Hemodynamic changes in the circle of Willis due to the entrance of embolus are observed. The effect of material properties on the distribution ratio and dynamics of motion of the emboli in the cerebral arterial network is also analyzed. Our results reveal that as the rigidity of emboli increases, higher proportion of them tend to enter to the larger arteries (e.g., middle cerebral artery). Scrutinizing the amount of stress acting on the emboli represented in this paper can broaden our understanding of the rheological phenomenon (e.g., lysis or growth of emboli during embolism). The approach of considering different material properties of the thrombus in a patient-specific computational model not only enable us to better understand the roll of biomechanical parameters causing the embolism, but also lead to a better clinical decision making to manage patients with stroke. 相似文献
177.
The peripheral endoplasmic reticulum forms a dynamic network of interconnected membrane tubules. Although some determinants of this striking architecture are known, the mechanism underlying fusion of individual tubules has remained elusive. Two studies now identify atlastin proteins as key mediators of homotypic fusion of endoplasmic reticulum membranes. 相似文献
178.
Concentrations of some radionuclides, including137Cs, in desert truffles in Kuwait were studied and compared with similar samples from other countries in the Middle East, namely
Iran, Egypt, and Tunisia. In addition, sand samples from Kuwait were assayed to calculate the transfer factor of the radionuclides
under consideration. The measured concentrations of40K,226Ra, and137Cs show that137Cs is much higher in Egyptian samples, whereas40K is much lower in samples from Tunisia. The average effective dose equivalent calculated for the Kuwaiti population according
to their diet habits was found to be in the range 0.14-0.23 ΜSv/a. The results are compared with values from other countries. 相似文献
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Afzaal Muhammad Saeed Farhan Arshad Muhammad Umair Nadeem Muhammad Tahir Saeed Muhammad Tufail Tabussam 《Probiotics and antimicrobial proteins》2019,11(4):1348-1354
Probiotics and Antimicrobial Proteins - The objective of this work was to explore the effect of two encapsulating polysaccharides (sodium alginate and carrageenan) on the viability of probiotic... 相似文献