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251.
Maryam Abolghasemi Sadra Samavarchi Tehrani Tooba Yousefi Ansar Karimian Ata Mahmoodpoor Aliakbar Ghamari Farhad Jadidi-Niaragh Mehdi Yousefi Hossein Samadi Kafil Milad Bastami Mahdi Edalati Shirin Eyvazi Mohsen Naghizadeh Niloufar Targhazeh Bahman Yousefi Amin Safa Maryam Majidinia Vahid Rameshknia 《Journal of cellular physiology》2020,235(6):5008-5029
Breast cancer is one of the most lethal malignancies in women in the world. Various factors are involved in the development and promotion of the malignancy; most of them involve changes in the expression of certain genes, such as microRNAs (miRNAs). MiRNAs can regulate signaling pathways negatively or positively, thereby affecting tumorigenesis and various aspects of cancer progression, particularly breast cancer. Besides, accumulating data demonstrated that miRNAs are a novel tool for prognosis and diagnosis of breast cancer patients. Herein, we will review the roles of these RNA molecules in several important signaling pathways, such as transforming growth factor, Wnt, Notch, nuclear factor-κ B, phosphoinositide-3-kinase/Akt, and extracellular-signal-regulated kinase/mitogen activated protein kinase signaling pathways in breast cancer. 相似文献
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It is generally believed that during development, neurons are usually produced in excess. Cell death occurs in the developing nervous system. The survival of the developing neurons depends on many factors derived from the target sites, of which the neuronal trophic factors are by far the best known. Stem cell factor (SCF) and its receptor, c-kit, is expressed in cells of nervous system during development and adulthood. Although the role of SCF/c-kit in the nervous system is so far not clear, in vitro studies indicate that SCF/c-kit is trophic to certain neurons derived from neural crest and cerebral cortex. In this study the effects of anti-c-kit antibody on cell death in the newborn chick cerebral cortex have been investigated. Injection of anti-c-kit antibody into the cisterna magnum increased the number of cell death and resulted in thinning of the cerebral cortex as compared to that from the control group. It is concluded that SCF/c-kit is essential for cortical progenitor cell survival in the cerebral cortex. Moreover, this method may be applied to the other factors and different CNS regions, allowing identification of factors involved in cell death. It additionally re-emphasizes the importance of further investigations into the potential roles of SCF/c-kit signaling in neurodegenerative diseases. 相似文献
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Background
Despite the presence of papillary structures and papillary tumors in humans, the mechanism of papillae formation is unknown. We describe herein a novel role for Niemann-Pick disease type 2C (NPC2) protein, a cholesterol binding protein in the lysosome, in papillae formation.Methodology/Principal Finding
We examined NPC2 protein expression in surgical samples of papillary tissues by immunohistochemical stain, and all papillary tissues expressed NPC2 protein in the epithelium. To examine our hypothesis of NPC2 protein-mediated papillae formation, we carried out xenograft experiments using wild H460 cells (large cell lung carcinoma cell line) that constitutively expressed abundant NPC2 protein and NPC2 protein-depleted H460 cells by NPC2 shRNA. The xenografts of wild H460 cells and empty shRNA vector cells showed distinct papillae formation, whereas NPC2 protein-depleted H460 cells displayed markedly reduced or no papillae. Since all papillary tissues have open spaces we examined whether NPC2 protein might also contribute to the creation of open spaces. The TUNEL assay in the xenografts of wild and empty shRNA vector H460 cells showed massive cell death, and NPC2 protein-depleted cells displayed minimal cell death. Measurement of caspase 3/7 activities in cultured H460 cells supported NPC2 protein-mediated apoptotic cell death. The presence of excess NPC2 protein, however, did not always produce papillae as seen in the xenografts of CHO cells that were stably transfected with NPC2.Conclusions/Significance
The NPC2 protein of certain cells forms papillae coupled with apoptosis that creates open space. This protein may have future applications to modulate papillae formation and papillary growth in tumor tissues. 相似文献256.
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Jazireian Parham Sasani Soheila Talesh Assarzadegan Farhad Azimian Mojtaba 《Molecular biology reports》2020,47(12):9659-9665
Molecular Biology Reports - Multiple sclerosis (MS) is an autoimmune-type inflammatory disorder in human central nervous system. Recombinant interferon beta (IFN-β) decreases the number of... 相似文献
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Lotfi Ramin Davoodi Akram Mortazavi Seyed Hamidreza Gorgin Karaji Ali Tarokhian Hanieh Rezaiemanesh Alireza Salari Farhad 《Molecular biology reports》2020,47(10):7745-7754
Molecular Biology Reports - Timely and successful resolution of acute inflammation plays a crucial role in preventing the development of chronic airway inflammation in allergic rhinitis (AR). This... 相似文献
259.
Narges Rostami Afshin Nikkhoo Yalda Khazaei-poul Shohreh Farhadi Melika Sadat Haeri Sadaf Moghadaszadeh Ardebili Nasimeh Aghaei Vanda Fatemeh Atyabi Afshin Namdar Masoumeh Baghaei Navideh Haghnavaz Tohid Kazemi Mehdi Yousefi Ghasem Ghalamfarsa Gholamabas Sabz Farhad Jadidi-Niaragh 《Journal of cellular physiology》2020,235(12):9702-9717