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Six heifers, aged 8-10 months, and 4 cows, aged 4-12 years, were used for studying the conformation of the cerebral ventricles on mouldings, and the topography on scanographs and frozen cuts. The morphologic changes with age concern the height of the 3rd ventricle, the extension of the pellucid septum and the stereotaxic topography. The stress is put on the variability of the volume of the lateral ventricles and the permanence of a vast and patent recessus olfactorius, with easy external landmarks. 相似文献
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Purification and partial characterization of rat macrophage Fc receptor and binding factor for IgA 总被引:4,自引:0,他引:4
C A Fargeas M Scholler A Pini D Wachsmann P Poindron J P Klein 《Biochimica et biophysica acta》1990,1037(3):344-350
By using a biotinylated ligand and Western blotting techniques, a receptor (RFc alpha) and a binding factor (BF) for IgA were detected, respectively, on membrane and in the cell-free culture supernatant of rat peritoneal macrophages. Extraction of the RFc alpha was obtained by solubilization of macrophages with Nonidet P-40, and purification was performed by HPLC affinity chromatography on a column derivatized with IgA. RFc alpha is formed of two subunits, with molecular masses of 56 and 70 kDa, which are both involved in the IgA binding ability of rat peritoneal macrophages. IgABF was recovered from the cell-free supernatant of a short-term culture of rat macrophages and was affinity-purified in the same manner as RFc alpha. Like RFc alpha, IgABF retained its IgA binding activity in its native, as well as denatured form. Since the molecular masses of RFc alpha and IgABF are similar, and IgABF competes with RFc alpha for IgA binding, one can assume that IgABF probably represents a shed RFc alpha. 相似文献
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A possible improvement for structure-based drug design illustrated by the discovery of a Tat HIV-1 inhibitor 总被引:5,自引:0,他引:5
Montembault M Vo-Thanh G Deyine A Fargeas V Villiéras M Adjou A Dubreuil D Esquieu D Grégoire C Opi S Péloponèse JM Campbell G Watkins J de Mareuil J Aubertin AM Bailly C Loret E Lebreton J 《Bioorganic & medicinal chemistry letters》2004,14(6):1543-1546
The HIV-1 Tat protein is a promising target for AIDS therapy, due to its extra-cellular roles against the immune system. From the 2D-NMR structure of Tat, we have designed molecules, called TDS, able to bind to Tat and inhibit HIV-1 replication in vitro. This new family of antivirals is composed of a triphenylene aromatic ring substituted with at least one carbon chain bearing a succinimide group. These ligands are prepared from triphenylene or 2,6,10-trimethylphenylene in 3-6 steps depending on the target molecule. 相似文献
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Involvement of different mechanisms in the stimulatory effects of cholecystokinin octapeptide on gastrointestinal and colonic motility in dogs 总被引:1,自引:0,他引:1
M J Fargeas G Bassotti J Fioramonti L Bueno 《Canadian journal of physiology and pharmacology》1989,67(10):1205-1212
The effects of an intravenous infusion of cholecystokinin octapeptide (CCK-8, 1 microgram.kg-1.h-1) were investigated in conscious fasted dogs chronically fitted with strain-gauge transducers on the antrum, the jejunum, and the colon. Attempts to antagonize the increase of motility appearing at the three levels during CCK infusion were made using different blockers to elucidate the mechanisms involved. Asperlicin (a specific CCK antagonist) blocked the effects of CCK-8 at the three levels, while atropine and somatostatin were only effective in the jejunum and colon. Methyl-levallorphan (a mu-opiate antagonist that poorly crosses the blood-brain barrier) antagonized the CCK-induced colonic stimulation when intracerebroventricularly administered. Serotonin, histamine, substance P, and K-antagonists as well as a benzodiazepine did not modify the CCK-8 induced stimulation. It was concluded that the stimulatory effect of CCK-8 resulted from (a) a direct stimulation of the smooth muscle cells at gastric level, (b) a cholinergic activation of the jejunum and the colon, and (c) the involvement of a mu-opioid central component in the colonic response only. 相似文献