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排序方式: 共有874条查询结果,搜索用时 15 毫秒
871.
Habib Insan Anjum Farah Mohammad Taj Sulaimani Md Nayab Shafie Alaa Almehmadi Mazen Yadav Dharmendra Kumar Sohal Sukhwinder Singh Hassan Md Imtaiyaz 《Molecular and cellular biochemistry》2022,477(5):1361-1370
Molecular and Cellular Biochemistry - Head and neck squamous cell carcinoma (HNSCC) is a prevalent malignancy with a poor prognosis, whose biomarkers have not been studied in great detail. We have... 相似文献
872.
S. Radwan 《Hydrobiologia》1984,112(2):117-124
Correlations were studied between 38 species and forms of common pelagic rotifers occurring in lakes of different trophy and 11 physical and chemical factors of the environment. Temperature, oxygen, electrolytic conductivity and calcium can have a direct influence on the occurrence of many species. The remaining chemical factors had only small effects. 相似文献
873.
Wagdy M. Eldehna Mahmoud F. Abo-Ashour Tarfah Al-Warhi Sara T. Al-Rashood Amal Alharbi Rezk R. Ayyad Khayal Al-Khayal Maha Abdulla Hatem A. Abdel-Aziz Rehan Ahmad Radwan El-Haggar 《Journal of enzyme inhibition and medicinal chemistry》2021,36(1):319
Mitochondrial anti-apoptotic Bcl2 and BclxL proteins, are overexpressed in multiple tumour types, and has been involved in the progression and survival of malignant cells. Therefore, inhibition of such proteins has become a validated and attractive target for anticancer drug discovery. In this manner, the present studies developed a series of novel isatin–indole conjugates (7a-j and 9a-e) as potential anticancer Bcl2 and BclxL inhibitors. The progression of the two examined colorectal cancer cell lines was significantly inhibited by all of the prepared compounds with IC50 ranges132–611 nM compared to IC50 = 4.6 µM for 5FU, against HT-29 and IC50 ranges 37–468 nM compared to IC50 = 1.5 µM for 5FU, against SW-620. Thereafter, compounds 7c and 7g were selected for further investigations. Interestingly, both compounds exhibited selective cytotoxicity against both cell lines with high safety to normal fibroblast (HFF-1). In addition, both compounds 7c and 7g induced apoptosis and inhibited Bcl2 and BclxL expression in a dose-dependent manner. Collectively, the high potency and selective cytotoxicity suggested that conjugates 7c and 7g could be a starting point for further optimisation to develop novel pro-apoptotic and antitumor agents towards colon cancer. 相似文献
874.
Abstract In the male dimorphic mite Sancassania berlesei, fighter males kill rivals with a pair of armoured legs whereas scrambler males are benign with unmodified legs. In an adaptive response mediated by colony pheromones, fighter expression increases at low colony density. Under the status‐dependent evolutionarily stable strategy (ESS) model we expected heavier final instar nymphs to become fighters. This was supported in group reared nymphs. In individually reared nymphs fighter expression was experimentally suppressed using two concentrations of colony pheromone. Here, male morph expression again depended on tritonymphal body mass and contact is therefore unnecessary for individuals to judge their status. Fighter suppression was greater in the higher pheromone treatment, but morph determination remained status dependent. The weight and length of fighters was lower than scramblers of same‐weight final instar nymphs, indicating a developmental trade‐off, and a cost not recouped at the adult stage. 相似文献