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51.
Sharif Moradi Parisa Torabi Saeed Mohebbi Sara Amjadian Piter Bosma Farnoush Faridbod Vahid Khoddami Morteza Hosseini Sadegh Babashah Maryam Ghotbaddini Arezoo Rasti Faezeh Shekari Hamid Sadeghi-Abandansari Jafar Kiani Mehdi Shamsara Mohammad Kazemi-Ashtiani Samira Gholami 《BioEssays : news and reviews in molecular, cellular and developmental biology》2020,42(6):2000042
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Samira Basharkhah Faezeh Sabet Sanaz Ahmadi Ghezeldasht Arman Mosavat Hamid Reza Jahantigh Elham Barati Khosrow Shamsian Masoud Saleh‐Moghaddam Hiva Sharebyani Tahereh Hassannia Seyed Ali Akbar Shamsian 《Microbiology and immunology》2019,63(11):449-457
Hepatitis C virus (HCV) infection is a major public health problem with about 1.75 million new HCV cases and 71 million chronic HCV infections worldwide. The study aimed to evaluate clinical, serological, molecular, and liver markers to develop a mathematical predictive model for the quantification of the HCV viral load in chronic HCV infected patients. In this cross‐sectional study, blood samples were taken from 249 recently diagnosed HCV‐infected subjects and were tested for liver condition, viral genotype, and HCV RNA load. Receiver operating characteristics (ROC) curves and multiple linear regression analysis were used to predict the HCV‐RNA load. Genotype 3 followed by genotype 1 were the most prevalent genotypes in Mashhad, Northeastern Iran. The maximum levels of viral load were detected in the mixed genotype group, and the lowest levels in the undetectable genotype group. The log of the HCV viral load was significantly associated with thrombocytopenia and higher serum levels of alanine transaminase (ALT). In addition, the log HCV RNA was significantly higher in patients with arthralgia, fatigue, fever, vomiting, or dizziness. Moreover, genotype 3 was significantly associated with icterus. A ROC curve analysis revealed that the best cut‐off points for serum levels of aspartate aminotransferase (AST), ALT, and alkaline phosphatase (ALP) were >31, >34, and ≤246 IU/L, respectively. Sensitivity, specificity, and positive predictive values for AST were 87.7%, 84.36%, and 44.6%, for ALT they were 83.51%, 81.11%, and 36%, and for ALP were 72.06%, 42.81%, and 8.3%, respectively. A mathematical regression model was developed that could estimate the HCV‐RNA load. Regression model: log viral load = 7.69 ? 1.01 × G3 ? 0.7 × G1 + 0.002 × ALT ? 0.86 × fatigue. 相似文献
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Dadkhah A Fatemi F Kazemnejad S Rasmi Y Ashrafi-Helan J Allameh A 《Molecular and cellular biochemistry》2006,281(1-2):145-152
Recently we reported that ferric reducing ability of plasma (FRAP) assay, as an index of total antioxidant activity, increases
in growing rats in response to high dose of vitamin K. In this study, it was found that acetaminophen (APAP) can cause elevation
in FRAP in suckling and adult rats. This study was initiated to assess the contribution of individual antioxidant factors
on elevation in FRAP. A surge in FRAP, 1 h after high dose APAP (250 or 450 mg/kg BW) administration was recorded in both
young as well as adults. Whereas, low dose drug (25 mg/kg) failed to alter FRAP in both the age groups. Time-course studies
show that drug-dependent elevation in FRAP begin rapidly, reaching a maximum at 1 h (> 500%). Increased FRAP was associated
with a marked increase (∼14-fold) in plasma bilirubin, 6 h after drug administration at 450 mg/kg only in suckling rats. Similarly,
APAP-related increase in superoxide dismutase activity in erythrocytes was limited to young rats of both the age groups. Other
factors measured during this period viz., plasma uric acid, bilirubin and total protein together with catalase activity of
erythrocytes remained unchanged in treated rats. Under these circumstances, APAP-related depletion in liver glutathione was
almost similar in both the age groups. During a 12 h study, the concentration of lipid peroxidation products, in liver of
treated groups remained within the levels of respective controls. The endpoint hepatotoxic effects of APAP was almost similar
in both the age groups, suggesting that like adults, immature rats can cope with toxic effects of APAP owing to their drug-dependent
induction in certain antioxidant factors. 相似文献
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Mojdeh Khosravi Hanieh Mohammad Rahimi Abdoreza Nazari Kaveh Baghaei Hamid Asadzadeh Aghdaei Shabnam Shahrokh Meysam Sharifdini Ana Claudia Torrecilhas Fatemeh Mehryab Hamed Mirjalali Faezeh Shekari Mohammad Reza Zali 《Journal of cellular and molecular medicine》2023,27(17):2614-2625
Hydatidosis is a disease caused by the larval stage of Echinococcus granulosus, which involves several organs of intermediate hosts. Evidence suggests a communication between hydatid cyst (HC) and hosts via extracellular vesicles. However, a little is known about the communication between EVs derived from HC fluid (HCF) and host cells. In the current study, EVs were isolated using differential centrifugation from sheep HCF and characterized by western blot, electron microscope and size distribution analysis. The uptake of EVs by human monocyte cell line (THP-1) was evaluated. The effects of EVs on the expression levels of pro- and anti-inflammatory cytokines were investigated using quantitative real-time PCR (RT-PCR), 3 and 24 h after incubation. Moreover, the cytokine level of IL-10 was evaluated in supernatant of THP-1 cell line at 3 and 24 h. EVs were successfully isolated and showed spherical shape with size distribution at 130.6 nm. After 3 h, the expression levels of pro-inflammatory cytokine genes (IL1Β, IL15 and IL8) were upregulated, while after 24 h, the expression levels of pro-inflammatory cytokines were decreased and IL13 gene expression showed upregulation. A statistically significant increase was seen in the levels of IL-10 after 24 h. The main mechanism of the communication between EVs derived from HCF and their host remains unclear; however, time-dependent anti-inflammatory effects in our study suggest that HC may modulate the immune responses via EVs. 相似文献
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Fatemeh Hosseininaveh Parvin Razavi Tabatabaei Ali Darvishzadeh Faezeh Bagheri 《Archives Of Phytopathology And Plant Protection》2013,46(14):1704-1715
Pistachio fruit hull borer, Arimania komaroffi Ragonot (Lep.: Pyralidae), is one the most important pests of pistachio in Iran. The larvae spin web as well as bore into young fruits, and the infested fruits fall off the trees. The second-generation adult moths appear in August and September, and their offspring feed on the fruit hull. Results indicated the presence of α-amylase, α-glucosidase, β-glucosidase, α-galactosidase, β-galactosidase and some proteases in the digestive tract of the pest. Highest activities of α-amylase, α-glucosidase, β-glucosidase, α-galactosidase and β-galactosidase were at pH 10, 7, 7, 6 and pH 6, respectively. Highest activities of trypsin, chymotrypsin and elastase of larval midgut were at pH 11. Zymogram analysis of α-amylase, α-glucosidase, β-glucosidase, tryptic, chymotryptic and elastase using native-PAGE revealed 1, 1, 2, 3, 3 and 2 bands of activity respectively, in A. komaroffi. One band was disappeared in the presence of the inhibitor TLCK, but no further inhibition by the inhibitors TPCK was observed. The results can be of help for designing new strategies for controlling the pistachio fruit hull borer based on natural proteases and carbohydrase inhibitors. 相似文献
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Marzieh Iranmanesh S. Jamil A. Fatemi Roza Ebrahimpour Faezeh Dahooee Balooch 《Biometals》2013,26(3):465-471
The present research is aimed to characterize the potential efficiency of two chelators after chromium(VI) administration for 60 days following two doses of 15 and 30 mg/kg chromium(VI) per body weight daily to male rats. However, the hypothesis that the two chelators might be more efficient as combined therapy than as single therapy in removing chromium(VI) from rat organs was considered. In this way, two known chelators deferasirox and deferiprone were chosen and given orally as a single or combined therapy for a period of 1 week. Chromium(VI) and iron concentrations in tissues were determined by flame atomic absorption spectroscopy. The combined chelation therapy results show that deferasirox and deferiprone are able to remove chromium(VI) ions from various tissues while iron concentration returned to normal levels and symptoms also decreased. 相似文献
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Sedigheh Zakeri Mandana Afsharpad Faezeh Ghasemi Ahmad Raeisi Qutbuddin Kakar Hoda Atta Navid Dinparast Djadid 《Experimental parasitology》2011,(1):167-172
The main aim of the present study was to investigate the frequency of SNPs-haplotypes of dhfr and dhps genes associated to sulfadoxine–pyrimethamine (SP) resistance in Plasmodium vivax clinical isolates circulating in a malaria endemic area, Pakistan. All 164 collected isolates were analyzed for SNPs-haplotypes at positions 13, 33, 57, 58, 61, 117 and 173 of pvdhfr and 383 and 553 of pvdhps genes using PCR–RFLP methods. All examined isolates were found to carry wild-type amino acids at positions 13, 33, 57, 61 and 173, while 58R and 117N mutations were detected among 15.2% and 53.6% of isolates, respectively. Based on the size polymorphism of pvdhfr genes at repeat region, type B (79.3%) was the most prevalent variant. The combination of pvdhfr and pvdhps haplotypes demonstrated nine distinct haplotypes. The three most prevalent haplotypes were I13P33F57S58T61S117I173/A383A553 (43.9%), I13P33F57S58T61N117I173/A383A553 (33.6%) and I13P33F57R58T61N117I173/A383A553 (12.2%). The presence of mutant haplotypes is worrying and indicates the emergence of drug tolerant/resistant P. vivax isolates in Pakistan in near future. 相似文献