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381.
Camila Eduardo Marinho Selma Maria Almeida Santos Simone Cristina Yamasaki Paulo Flavio Silveira 《Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology》2009,179(5):635-642
To understand the role of peptidases in seminal physiology of Crotalus durissus terrificus, intra- and inter-seasonal activity levels of acid (APA), basic (APB), puromycin-sensitive (APN-PS) and puromycin-insensitive
neutral (APN-PI), cystyl (CAP), dipeptidyl-IV (DPPIV), type-1 pyroglutamyl (PAP-I) and prolyl-imino (PIP) aminopeptidases
as well as prolyl endopeptidase (POP) were evaluated in soluble (SF) and/or membrane-bound (MF) fractions of semen collected
from the ductus deferens of the male reproductive tract and from the posterior portion of the uterus. Seminal APB, PIP and
POP were detected in SF, while other peptidases were detected in SF and MF. Only the convoluted posterior uterus in winter
and autumn had semen. Relative to other examined peptidases, in general, APN-PI, APN-PS and APB activities were predominant
in the semen from the uterus and throughout the year in the semen from the ductus deferens, suggesting their great relevance
in the seminal physiology of C. d. terrificus. The levels of peptidase activities in the ductus deferens semen varied seasonally and were different from those of semen
in the uterus, suggesting that their modulatory actions on susceptible peptides are integrated to the male reproductive cycle
events and spermatozoa viability of this snake. 相似文献
382.
Selma Becherirat Fatemeh Valamanesh Mojgan Karimi Anne-Marie Faussat Jean-Marie Launay Cynthia Pimpie Amu Therwath Marc Pocard 《Translational oncology》2018,11(2):406-415
Antiangiogenics administration in colorectal cancer patients seemed promising therapeutic approach. Inspite of early encouraging results, it however gave only modest clinical benefits. When AAG was administered with discontinuous schedule, the disease showed acceleration in certain cases. Though resistance to AAG has been extensively studied, it is not documented for discontinuous schedules. To simulate clinical situations, we subjected a patient-derived CRC subcutaneous xenograft in mice to three different protocols: 1) AAG (bevacizumab) treatment for 30 days (group A) (group B was the control), 2) bevacizumab treatment for 50 days (group C) and bevacizumab for 30 days and 20 without treatment (group D), and 3) bevacizumab treatment for 70 days (group E) and 70 days treatment with a drug-break period between day 30 and 50 (group F). The tumor growth was monitored, and at sacrifice, the vascularity of tumors was measured and the proangiogenic factors quantified. Tumor phenotype was studied by quantifying cancer stem cells. Interrupting bevacizumab during treatment accelerated tumor growth and revascularization. A significant increase of proangiogenic factors was observed when therapy was stopped. On withdrawal of bevacizumab, as also after the drug-break period, the plasmatic VEGF increased significantly. Similarly, a notable increase of CSCs after the withdrawal and drug-break period of bevacizumab was observed (P<.01). The present study indicates that bevacizumab treatment needs to be maintained because discontinuous schedules tend to trigger tumor regrowth, and increase tumor resistance and CSC heterogeneity. 相似文献
383.