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Bas Brouwers Edson Mendes de Oliveira Maria Marti-Solano Fabiola B.F. Monteiro Suli-Anne Laurin Julia M. Keogh Elana Henning Rebecca Bounds Carole A. Daly Shane Houston Vikram Ayinampudi Natalia Wasiluk David Clarke Bianca Plouffe Michel Bouvier M. Madan Babu I. Sadaf Farooqi Jacek Mokrosiński 《Cell reports》2021,34(12):108862
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Nayely Garibay-Nieto Brianda Areli Hernández-Morán Eréndira Villanueva-Ortega María José Garcés-Hernández Karen Pedraza-Escudero América Arroyo-Valerio César Pedraza-Helvert Arturo Herrera-Rosas Estibalitz Laresgoiti-Servitje Mireya León-Hernández Neyla Baltazar-López Joselin Hernández-Ruíz Fabiola Serratos-Canales Gloria Queipo-García Sarah Elizabeth Messiah Srinivas Mummidi Juan Carlos López-Alvarenga 《Endocrine practice》2022,28(3):315-320
ObjectiveTo describe a third-degree polynomial function (hysteresis) of the effect size of age, obesity, and insulin sensitivity over the carotid intima-media thickness (c-IMT), in the pediatric and adult groups.MethodsA quasi-experimental study with fixed factor analysis of age (children aged 8-12 years, n = 73; adults aged 21-45 years, n = 82) and obesity (yes, n = 76; no, n = 79) was conducted to analyze the effect on the c-IMT and Matsuda insulin sensitivity index values. This quasi-experimental design was analyzed with robust regression modeling.ResultsThe additive effect of obesity, independent of age, was evident in the case of the c-IMT values. There was no interaction effect, but a significant difference between participants with normal weight and those with obesity was found (P < .0001). The difference between adults and children was also significant, but the effect size was smaller. A model was created based on age, Tanner stage, and obesity using the c-IMT and Matsuda insulin sensitivity index values. A linear function fit as R2, and the cubic function estimated parameters like a polynomial model.ConclusionThis practical study design showed that children with obesity displayed the same levels of carotid intima-media abnormalities as adults with obesity. The polynomial shape of the model suggests potentially poor outcomes that resemble the hysteresis process and may predict chronic cardiometabolic events during early adulthood. 相似文献
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Felix Horlamus Andreas Wittgens Philipp Noll Jan Michler Inga Müller Fabiola Weggenmann Claudia Oellig Frank Rosenau Marius Henkel Rudolf Hausmann 《Global Change Biology Bioenergy》2019,11(1):260-268
The purpose of this study was to evaluate Cellvibrio japonicus as a potential host strain for one‐step bioconversion of hemicellulose polymers to value‐added products. C. japonicus could be cultivated on all main lignocellulose monosaccharides as well as xylan polymers as a sole carbon source. This is particularly interesting as most industrially relevant bacteria are neither able to depolymerize wood polymers nor metabolize most hemicellulose monosaccharides. As a result, lignocellulose raw materials typically have to be degraded employing additional processes while the complete conversion of all lignocellulose sugars remains a challenge. Exemplary for a value‐added product, a one‐step conversion of xylan polymers to mono‐rhamnolipid biosurfactants with C. japonicus after transformation with the plasmid pSynPro8oT carrying the genes rhlAB was demonstrated. As achieved product yields in this one‐step bioconversion process are comparably low, many challenges remain to be overcome for application on an industrial scale. Nonetheless, this study provides a first step in the search for establishing a future host strain for bioeconomy, which will ideally be used for bioconversion of lignocellulose polymers with as little exhaustive pretreatment as possible. 相似文献
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Hubbard Tru Cove Michael V. Green Austin M. Iannarilli Fabiola Allen Maximilian L. LaRose Summer H. Nagy Chris Compton Justin A. Lafferty Diana J.R. 《Biodiversity and Conservation》2022,31(11):2607-2624
Biodiversity and Conservation - Mammalian carnivores are elusive and enigmatic species that often play keystone roles in ecosystems through direct and indirect effects. Growing evidence shows that... 相似文献