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排序方式: 共有128条查询结果,搜索用时 15 毫秒
11.
Toma S Emionite L Fabia G Spadini N Vergani L 《The International journal of biological markers》2003,18(1):78-81
Chemoprevention can be defined as the use of specific natural or synthetic chemical agents to reverse, suppress, or prevent carcinogenic progression to invasive cancer. The knowledge of carcinogenic mechanisms provides the scientific rationale for chemoprevention. Epithelial carcinogenesis proceeds through multiple discernible stages of molecular and cellular alterations. Understanding of the multistep nature of carcinogenesis has evolved through highly controlled animal carcinogenesis studies, and these studies have identified three distinct phases: initiation, promotion and progression. Animal model studies have provided evidence that the development of cancer involves many different factors, including alterations in the structures and functions of different genes. Transitions between successive stages can be enhanced or inhibited in the laboratory by different types of agents, such activities providing the fundamental basis for chemoprevention. 相似文献
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Rational design of a CD4 mimic that inhibits HIV-1 entry and exposes cryptic neutralization epitopes 总被引:5,自引:0,他引:5
Martin L Stricher F Missé D Sironi F Pugnière M Barthe P Prado-Gotor R Freulon I Magne X Roumestand C Ménez A Lusso P Veas F Vita C 《Nature biotechnology》2003,21(1):71-76
The conserved surfaces of the human immunodeficiency virus (HIV)-1 envelope involved in receptor binding represent potential targets for the development of entry inhibitors and neutralizing antibodies. Using structural information on a CD4-gp120-17b antibody complex, we have designed a 27-amino acid CD4 mimic, CD4M33, that presents optimal interactions with gp120 and binds to viral particles and diverse HIV-1 envelopes with CD4-like affinity. This mini-CD4 inhibits infection of both immortalized and primary cells by HIV-1, including primary patient isolates that are generally resistant to inhibition by soluble CD4. Furthermore, CD4M33 possesses functional properties of CD4, including the ability to unmask conserved neutralization epitopes of gp120 that are cryptic on the unbound glycoprotein. CD4M33 is a prototype of inhibitors of HIV-1 entry and, in complex with envelope proteins, a potential component of vaccine formulations, or a molecular target in phage display technology to develop broad-spectrum neutralizing antibodies. 相似文献
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Van Mau N Missé D Le Grimellec C Divita G Heitz F Veas F 《The Journal of membrane biology》2000,177(3):251-257
Increasing evidence suggests that the HIV envelope binds through its surface (SU) gp120 not only to receptors and coreceptors,
but also to other components of the cellular membrane where the glycolipids appear to be good candidates. To assess the ability
of HIV-1 SU gp120 to penetrate into phospholipid membranes, we carried out a study of the interactions between a recombinant
SU gp120 from HIV-1/HXB2 and artificial lipid monolayers mimicking the composition of the outer leaflet of the lymphocytes
and which were spread at the air-water interface. We show that the protein, in its aggregated form, has amphipathic properties
and that the insertion of this amphipathic species into lipids is favored by the presence of sphingomyelin. Furthermore, cholesterol
enhances the penetration into mixed phosphatidylcholine-sphingomyelin monolayers. Coexistence of different physical states
of the lipids and thus of domains appears to play a major role for protein penetration independently of the presence of receptors
and coreceptors.
Received: 24 April 2000/Revised: 11 July 2000 相似文献
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Thomas F Lafferty KD Brodeur J Elguero E Gauthier-Clerc M Missé D 《Biology letters》2012,8(1):101-103
We explored associations between the common protozoan parasite Toxoplasma gondii and brain cancers in human populations. We predicted that T. gondii could increase the risk of brain cancer because it is a long-lived parasite that encysts in the brain, where it provokes inflammation and inhibits apoptosis. We used a medical geography approach based on the national incidence of brain cancers and seroprevalence of T. gondii. We corrected reports of incidence for national gross domestic product because wealth probably increases the ability to detect cancer. We also included gender, cell phone use and latitude as variables in our initial models. Prevalence of T. gondii explained 19 per cent of the residual variance in brain cancer incidence after controlling for the positive effects of gross domestic product and latitude among nations. Infection with T. gondii was associated with a 1.8-fold increase in the risk of brain cancers across the range of T. gondii prevalence in our dataset (4-67%). These results, though correlational, suggest that T. gondii should be investigated further as a possible oncogenic pathogen of humans. 相似文献
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There was a strong correlation between measurements of red core disease of strawberry, assessed as percentage lengths of the adventitious roots with red steles, and ELISA values obtained from the same root systems using a polyclonal antiserum raised to Phytophthora fragariae. ELISA grouped twelve host cultivar/pathogen isolate combinations into three categories, highly resistant, partially resistant and susceptible, which agreed with disease incidence after inoculation. 相似文献
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