Activity correlations in the phorbol ester series

Activity correlations in the phorbol ester series. The production of inflammation by phorbol esters on mammalian skin correlates on a structural basis with in vitro measurements of lymphocyte mitogenesis and mobilization of prostaglandins. All of the pro-inflammatory phorbol esters tested in our laboratory have been shown to activate the enzyme protein kinase C, and such an interaction could in large part explain the induction of an inflammatory response in vivo. Certain of these compounds additionally induce aggregation of human and rabbit blood platelets. This activity does not structurally correlate with the induction of inflammation but may correlate with the known tumour-promoting actions of phorbol derivatives. Compounds which induce platelet aggregation stimulate the secretion of a biologically active substance which we have termed 'Factor W'. The production of Factor W occurs into human plasma following platelet stimulation by phorbol tumour-promoting agents. It is an unstable substance, distinct in its aggregating properties from phorbol esters, ADP, 5-hydroxytryptamine, thrombin, platelet aggregating factor and the products of arachidonate oxidative metabolism.     

THE REPRODUCTIVE ANATOMY OF PAROPEAS ACHATINACEUM AND A NEW CONCEPT OF PAROPEAS (PULMONATA: ACHATINOIDEA: SUBULINIDAE)

The majority of subulinid land snails are known only as shellsand generic groupings need to be revised on the basis of theirinternal anatomy. Paropeas achatinaceum (new combination) isa synanthropic subulinid that is widely distributed around theIndo-Pacific region. Features of the genital anatomy and radulademonstrate that Paropeas should be rejected as a subgenus ofProsopeas and be recognised as a distinct genus. The radulaof Paropeas is more typical of a subulinid than is that of Prosopeaswhich proves to be highly modified for a carnivorous diet. Thespermatophore of Paropeas is inserted directly into the oviductwhere it releases sperm through its porous tail before beingdigested in the bursa copulatrix. (Received 23 September 1992; accepted 11 November 1993)     

COMPARISON OF EUTHECOSOMATOUS PTEROPODS IN THE PLANKTON AND SEDIMENTS OFF BARBADOS, WEST INDIES

The euthecosomatous pteropod fauna of Barbados plankton wascompared with euthecosome shells occurring in recent sediments.Twenty species of euthecosomes were collected in the same relativeabundance in both provinces. Differences in the average sizesof Spiratella inflata and Creseis virgula conica, the most commonspecies were not statistically significant although differencesin the size-frequency histograms were noted. It is concludedthat euthecosomes deposited in the upper sediment layers offBarbados accurately reflect the species composition and relativeabundance of euthecosome species in the plankton. ¹Supported by a Postgraduate Scholarship from the National ResearchCouncil of Canada and NRC Grant No. A5248 to Dr. C.M. Lalli. ²Present address: Department of Oceanography, Dalhousie University,Halifax, Nova Scotia, Canada.     

Demographic effects of temperature‐dependent sex determination: will tuatara survive global warming?

Global climate change is of particular concern for small and isolated populations of reptiles with temperature-dependent sex determination because low genetic variation can limit adaptive response in pivotal temperatures, leading to skewed sex ratios. We explore the demographic consequences of skewed sex ratios on the viability of a tuatara population characterized by low genetic diversity. We studied the rare species of tuatara ( Sphenodon guntheri ) on the 4 ha North Brother Island in New Zealand over two nesting seasons and captured 477 individuals, with a 60% male bias in the adult population. Females first breed at 15 years and have extremely low rates of gravidity, producing clutches of three to eight eggs every 9 years. Simulations of the population using population viability analysis showed that the current population is expected to persist for at least 2000 years at hatchling sex ratios of up to 75% male, but populations with 85% male hatchlings are expected to become extinct within approximately 300 years (some eight generations). Incorporation of inbreeding depression increased the probability of extinction under male biased sex ratios, with no simulated populations surviving at hatchling sex ratios >75% male. Because recent models have predicted that climate change could lead to the production of all male S. guntheri hatchlings by 2085, we examined whether periodic intervention to produce mixed or female biased sex ratios would allow the population to survive if only males were produced in natural nests. We show that intervention every 2–3 years could buffer the effects of climate change on population sex ratios, but translocation to cooler environs might be more cost-effective. Climate change threatens tuatara populations because neither modified nesting behaviour nor adaptive response of the pivotal temperature can modify hatchling sex ratios fast enough in species with long generation intervals.     

Evidence for Regionally Synchronized Cycles in Texas Quail Population Dynamics

Abstract: Knowledge of the possible role of cyclic behavior in wildlife dynamics assists in understanding and managing populations. Using spectrum, we analyzed time series (1978-2002) on the abundance of northern bobwhites (Colinus virginianus) and scaled quail (Callipepla squamata) in several ecological regions in Texas, USA, to test for the presence of cycles; we also tested whether drought severity (Modified Palmer Drought Severity Index) exhibited cyclic dynamics and whether quail and drought cycles were synchronized among regions. We found evidence of population cyclicity in all ecoregions we tested (5 for bobwhites, 4 for scaled quail) based on both Texas Parks and Wildlife and North American Breeding Bird Survey count data. Periods of the observed cycles generally were 5-6 years (bobwhites) or 2-3 years (scaled quail), depending on ecoregion and data source. Cyclicity was most pronounced for bobwhites in the Rolling Plains (north TX) and the South Texas Plains. The Palmer Index exhibited a roughly 5-year cycle in 5 of 6 regions we tested. A 5-year bobwhite and Palmer Index cycle were synchronous in 3 contiguous ecoregions totaling 27,200,000 ha. Wet-dry cycles seemed to synchronize bobwhite cycles in Texas. Our results suggest that habitat manipulations aimed at improving habitat conditions during dry periods, such as reducing livestock stocking rates, could provide ground cover similar to that available in wet periods.     

Habitat Selection of Rocky Mountain Elk in a Nonforested Environment

Abstract: Recent expansions by Rocky Mountain elk (Cervus elaphus) into nonforested habitats across the Intermountain West have required managers to reconsider the traditional paradigms of forage and cover as they relate to managing elk and their habitats. We examined seasonal habitat selection patterns of a hunted elk population in a nonforested high-desert region of southwestern Wyoming, USA. We used 35,246 global positioning system locations collected from 33 adult female elk to model probability of use as a function of 6 habitat variables: slope, aspect, elevation, habitat diversity, distance to shrub cover, and distance to road. We developed resource selection probability functions for individual elk, and then we averaged the coefficients to estimate population-level models for summer and winter periods. We used the population-level models to generate predictive maps by assigning pixels across the study area to 1 of 4 use categories (i.e., high, medium-high, medium-low, or low), based on quartiles of the predictions. Model coefficients and predictive maps indicated that elk selected for summer habitats characterized by higher elevations in areas of high vegetative diversity, close to shrub cover, northerly aspects, moderate slopes, and away from roads. Winter habitat selection patterns were similar, except elk shifted to areas with lower elevations and southerly aspects. We validated predictive maps by using 528 locations collected from an independent sample of radiomarked elk (n = 55) and calculating the proportion of locations that occurred in each of the 4 use categories. Together, the high- and medium-high use categories of the summer and winter predictive maps contained 92% and 74% of summer and winter elk locations, respectively. Our population-level models and associated predictive maps were successful in predicting winter and summer habitat use by elk in a nonforested environment. In the absence of forest cover, elk seemed to rely on a combination of shrubs, topography, and low human disturbance to meet their thermal and hiding cover requirements.     

DISTRIBUTION OF MOLLUSCS ACROSS A PNEUMATOPHORE BOUNDARY IN A SMALL BAY IN NORTHWESTERN AUSTRALIA

The number of species, total density and total biomass of molluscswere examined for 50 m either side of an Avicennia pneumatophoreboundary in the Bay of Rest, North West Cape, Western Australia(22°18'S; 114° 08'E). Two mollusc assemblages were found,separated almost exactly at the pneumatophore boundary. Themudflat association had more species of molluscs but a lowertotal density and total biomass than the assemblage in the Avicenniazone. Stations among pneumatophores on the seaward fringe ofthe Avicennia zone were more diverse and had a greater densityand biomass than stations among the trees. Possible reasonsfor the pneumatophore area having a higher density and biomassof molluscs than the adjacent mudflat and tree zones are discussed. (Received 18 June 1985;