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Lior Ungar Nir Yosef Yael Sela Roded Sharan Eytan Ruppin Martin Kupiec 《Nucleic acids research》2009,37(12):3840-3849
Telomeres are structures composed of repetitive DNA and proteins that protect the chromosomal ends in eukaryotic cells from fusion or degradation, thus contributing to genomic stability. Although telomere length varies between species, in all organisms studied telomere length appears to be controlled by a dynamic equilibrium between elongating mechanisms (mainly addition of repeats by the enzyme telomerase) and nucleases that shorten the telomeric sequences. Two previous studies have analyzed a collection of yeast deletion strains (deleted for nonessential genes) and found over 270 genes that affect telomere length (Telomere Length Maintenance or TLM genes). Here we complete the list of TLM by analyzing a collection of strains carrying hypomorphic alleles of most essential genes (DAmP collection). We identify 87 essential genes that affect telomere length in yeast. These genes interact with the nonessential TLM genes in a significant manner, and provide new insights on the mechanisms involved in telomere length maintenance. The newly identified genes span a variety of cellular processes, including protein degradation, pre-mRNA splicing and DNA replication. 相似文献
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Background
Sequence comparison is one of the most prominent tools in biological research, and is instrumental in studying gene function and evolution. The rapid development of high-throughput technologies for measuring protein interactions calls for extending this fundamental operation to the level of pathways in protein networks. 相似文献57.
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Evaluation of the fluid flow pattern in a non-pregnant uterus is important for understanding embryo transport in the uterus.
Fertilization occurs in the fallopian tube and the embryo (fertilized ovum) enters the uterine cavity within 3 days of ovulation.
In the uterus, the embryo is conveyed by the uterine fluid for another 3 to 4 days to a successful implantation site at the
upper part of the uterus. Fluid movements within the uterus may be induced by several mechanisms, but they seem to be dominated
by myometrial contractions. Intra-uterine fluid transport in a sagittal cross-section of the uterus was simulated by a model
of wall-induced fluid motion within a two-dimensional channel. The time-dependent fluid pattern was studied by employing the
lubrication theory. A comprehensive analysis of peristaltic transport resulting from symmetric and asymmetric contractions
is presented for various displacement waves on the channel walls. The results provide information on the flow field and possible
trajectories by which an embryo may be transported before implantation at the uterine wall. 相似文献
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Ruppin E 《Nature reviews. Neuroscience》2002,3(2):132-141
In this article, I discuss the use of neurally driven evolutionary autonomous agents (EAAs) in neuroscientific investigations. Two fundamental questions are addressed. Can EAA studies shed new light on the structure and function of biological nervous systems? And can these studies lead to the development of new tools for neuroscientific analysis? The value and significant potential of EAA modelling in both respects is demonstrated and discussed. Although the study of EAAs for neuroscience research still faces difficult conceptual and technical challenges, it is a promising and timely endeavour. 相似文献