排序方式: 共有46条查询结果,搜索用时 15 毫秒
21.
Jun Wang Eylem Aydoğdu Srijita Mukhopadhyay Luisa A. Helguero Cecilia Williams 《Journal of cellular physiology》2019,234(12):22220-22233
miR-206 is known to suppress breast cancer. However, while it is expressed in mammary stem cells, its function in such nontumor cells is not well understood. Here, we explore the role of miR-206 in undifferentiated, stem-like mammary cells using the murine mammary differentiation model HC11, genome-wide gene expression analysis, and functional assays. We describe the miR-206-regulated gene landscape and propose a network whereby miR-206 suppresses tumor development. We functionally demonstrate that miR-206 in nontumor stem-like cells induces a G1–S cell cycle arrest, and reduces colony formation and epithelial-to-mesenchymal transition markers. Finally, we show that addition of miR-206 accelerates the mammary differentiation process along with related accumulation of lipids. We conclude that miR-206 impacts a network of signaling pathways, and acts as a regulator of proliferation, stemness, and mammary cell differentiation in nontumor stem-like mammary cells. Our study provides a broad insight into the breast cancer suppressive functions of miR-206. 相似文献
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In this study, the Phanerotomini of Turkey collected between July 1959 and July 2004, are listed. A total of thirteen Phanerotomini
species were determined, and six of these are reported for the first time from Turkey. Phanerotoma (Bracotritoma) permixtellae Fischer, 1968 was reared from a new natural host Recurvaria pistaciicola (Danilevskii, 1955) (Lepidoptera: Gelechiidae). With this present study an illustrated identification key for the Phanerotomini
of Turkey is given. The distribution of the Phanerotomini species is discussed according to the phytogeographical provinces
of Turkey. 相似文献
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Sarah B. Daly Jill E. Urquhart Emma Hilton Edward A. McKenzie Richard A. Kammerer Malcolm Lewis Bronwyn Kerr Helen Stuart Dian Donnai David A. Long Berk Burgu Ozgu Aydogdu Murat Derbent Sixto Garcia-Minaur Willie Reardon Blanca Gener Stavit Shalev Rupert Smith Adrian S. Woolf Graeme C. Black William G. Newman 《American journal of human genetics》2010,87(2):309
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Kuku I Bayraktar MR Kaya E Erkurt MA Bayraktar N Cikim K Aydogdu I 《Mediators of inflammation》2005,2005(3):171-174
Multiple myeloma (MM) is a malignant disease characterized by the clonal proliferation of plasma cells within the bone marrow. Several cytokines have been demonstrated to be involved in the control of growth, progression, and dissemination of MM. We determined serum levels of interleukin-1beta (IL-1beta), soluble interleukin-2 receptor (sIL-2R), interleukin-6 (IL-6), interleukin-8 (IL-8), tumor necrosis factor-alpha (TNF-alpha), and C-reactive protein (CRP) in 14 newly diagnosed MM patients. The median age of the patients was 63.4 +/- 10.8 years and all of the patients were stage III (classified according to the Durie-Salmon classification). The same parameters were measured in 15 healthy controls. In addition, we also examined the effects of vincristine-adriamycin-dexamethasone (VAD) therapy on the same parameters and mediators as well as the relationship among the parameters in the same patient groups. The serum concentrations of TNF-alpha, IL-1beta, sIL-2R, IL-6, IL-8, and CRP (18.6 +/- 3.7 pg/mL, 10.1 +/- 2.8 pg/mL, 730 +/- 220 U/mL, 11.4 +/- 3.3 pg/mL, 23.9 +/- 8.3 pg/mL, and 49.9 +/- 19.5 mg/dL, resp) were significantly higher in newly diagnosed MM patients than in healthy controls (P < .0001). All of the parameters were found to be significantly reduced after chemotherapy. In conclusion, we found that after the VAD therapy, the level of these cytokines which are thought to play an important role in the pathogenesis of MM was significantly suppressed. This is the first study demonstrating strong impact of VAD treatment on circulating mediators of sIL-2R and IL-8 levels parameters. 相似文献
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The aim of this study was to investigate the effects of carnosine, a biological antioxidant, on the acute cardiac damage induced
by a single dose of adriamycin in rats. The experimental design consisted of four groups: Control (saline, i.p.); carnosine
(CAR; 10 mg/kg/day, i.p.); adriamycin (ADR; 16 mg/kg on the 14th day, i.p.); carnosine with adriamycin. Carnosine was given
2 weeks before and following adriamycin treatment. Blood samples were collected for analysis of plasma creatine kinase (CK)
and plasma antioxidant enzymes, glutathione peroxidase (GSH-Px), Cu, Zn-superoxide dismutase (SOD), and catalase (CAT). The
rats were then sacrificed, and the hearts were autopsied for hemodynamic study, ECG, and histopathological examination. Results
showed that adriamycin produced evident cardiac damage revealed by hemodynamic change, histological alterations, decreased
plasma antioxidant enzymes activities, and increased lipid peroxidation to the control value. Carnosine treatment led to significant
attenuation of adriamycin-induced cardiomyopathy revealed by normalization of the LVDP, ST interval, CK, SOD, GSH-Px, CAT,
and lipid peroxidation. An increase in oxidative stress and inactivation of SOD, GSH-Px, CAT by a single dose of adriamycin
were prevented when carnosine was given 2 weeks before and on the same day adriamycin treatment was administered. 相似文献
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Carlos Snchez-Ovejero Eylem Akdur Raúl Manzano-Romn Ana Hernndez-Gonzlez María Gonzlez-Snchez David Becerro-Recio Javier Gonzlez-Miguel Okan Akhan Carmen M. Cretu Kamenna Vutova Francesca Tamarozzi Mara Mariconti Enrico Brunetti Ambra Vola Massimo Fabiani Adriano Casulli Mar Siles-Lucas 《PLoS neglected tropical diseases》2020,14(11)
Cystic echinococcosis (CE) is a neglected zoonotic disease caused by Echinococcus granulosus sensu lato. Diagnosis and monitoring of CE rely primarily on imaging while serology is used as a confirmatory test. However, imaging is not always conclusive and currently available serological assays have suboptimal sensitivity and specificity, lack standardization, and are not useful for patients´ follow-up. Seroassays for CE are usually based on hydatid fluid (HF), a complex, variable antigenic mixture, and cross-reactivity exists especially with alveolar echinococcosis. Recombinant proteins based on immunogenic antigens most abundant in HF, such as AgB1, AgB2 and Ag5, have been used to overcome these limitations. None of them so far showed potential to replace HF; however, their performance have been largely tested on a limited number of samples, and comparison of different antigens using the same cohort has been rarely performed. The combination of several immunogenic epitopes in a single recombinant protein could enhance test sensitivity. For the diagnosis and follow-up of patients with CE, we compared the performance of the crude HF, previously described recombinant 2B2t antigen, and GST-tagged version of 2B2t, and novel designed recombinants (GST-Ag5t and the GST-DIPOL chimera containing AgB1, AgBB2 and Ag5 epitopes) by IgG-ELISA format. Samples belong to a retrospective cohort of 253 well-characterized patients with CE, previously described for the evaluation of the 2B2t antigen, 92 patients with alveolar echinococcosis, and 82 healthy donors. The reference standard for CE diagnosis was the presence of a CE lesion as diagnosed by ultrasonography. The highest sensitivity was obtained with HF [86.7%, 95% confidence interval (CI): 81.2–91.0], followed by GST-2B2t (70.0%, 95% CI: 63.1–76.2), 2B2t (65.5%, 95% CI: 58.5–72.0), GST-Ag5t (64.5%, 95% CI: 57.5–71.1) and GST-DIPOL (63.1%, 95% CI: 56.0–69.7). The GST-2B2t had the best specificity (95.8%, 95% CI: 88.3–99.1) and the lowest cross-reactivity (38.7%, 95% CI: 27.6–50.6). Good response to treatment also correlated to negative test results in the GST-2B2t ELISA. While none of the tested recombinant antigen appears suitable to replace HF for the diagnosis of CE, GST-2B2t should be further explored as a confirmation test, based on its high specificity and low cross-reactivity, and for the follow-up after treatment in those patients with positive serology for this antigen. 相似文献
27.
Olivier De Clerck Shu-Min Kao Kenny A. Bogaert Jonas Blomme Fatima Foflonker Michiel Kwantes Emmelien Vancaester Lisa Vanderstraeten Eylem Aydogdu Jens Boesger Gianmaria Califano Benedicte Charrier Rachel Clewes Andrea Del Cortona Sofie D’Hondt Noe Fernandez-Pozo Claire M. Gachon Marc Hanikenne John H. Bothwell 《Current biology : CB》2018,28(18):2921-2933.e5
28.
Asmatulu Eylem Subeshan Balakrishnan Twomey Janet Overcash Michael 《The International Journal of Life Cycle Assessment》2020,25(9):1783-1789
The International Journal of Life Cycle Assessment - Typically, the high energy required to manufacture nanomaterials is weighed against the benefits transferred to a product. Adequately... 相似文献
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