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71.
James Kennedy Anna Heiða Ólafsdóttir Svandís Eva Aradóttir Svanhildur Egilsdóttir Christophe Pampoulie 《Journal of fish biology》2024,104(3):598-610
Black ruff (Centrolophus niger) is a rare and poorly studied species found in both the Atlantic and Pacific Oceans and also in the Mediterranean Sea. It is sporadically caught south of Iceland during the annual International Ecosystem Summer Survey of the Nordic Seas. In total, 43 specimens were caught from 2009 to 2021, of which 41 specimens were caught during 2017–2021. All specimens, except one, were caught using a pelagic trawl (cod-end mesh-size: 50 mm) close to the surface (trawl depth: 0–35 m) with in situ temperature ranging from 9 to 13°C. The area south of Iceland is characterized by having warmer temperatures than other areas around the island, which might be indicative of a northern limit for the distribution of black ruff. The fish were primarily in the range of 29–46 cm with a few larger individuals up to 71 cm. Fourteen fish, caught in 2017 and 2021, were dissected to gather biological information on this species. These fish were all juveniles with no obvious sign of gonad development. Correlations between total length, fork length, and standard length are presented. Otoliths were thin and delicate with a length of ~13–16 mm, and otolith size (length, width, and area) was correlated with fish size. Much of the stomach content was at an advanced stage of digestion, but some contents could be identified and consisted of invertebrates, primarily of the orders Amphipoda and Calanoida with some unidentified fish also present. 相似文献
72.
Guðbjörg Ólafsdóttir Vilhjálmur Svansson Sigurður Ingvarsson Eliane Marti Sigurbjörg Torsteinsdóttir 《Acta veterinaria Scandinavica》2008,50(1):44
One of the prerequisite for developing DNA vaccines for horses are vectors that are efficiently expressed in horse cells. 相似文献
73.
Harry Tagbor Matthew Cairns Kalifa Bojang Sheick Oumar Coulibaly Kassoum Kayentao John Williams Ismaela Abubakar Francis Akor Khalifa Mohammed Richard Bationo Edgar Dabira Alamissa Soulama Moussa Djimdé Etienne Guirou Timothy Awine Stephen Quaye Fanta Njie Jaume Ordi Ogobara Doumbo Abraham Hodgson Abraham Oduro Steven Meshnick Steve Taylor Pascal Magnussen Feiko ter Kuile Arouna Woukeu Paul Milligan Daniel Chandramohan Brian Greenwood 《PloS one》2015,10(8)
Background
The efficacy of intermittent preventive treatment for malaria with sulfadoxine-pyrimethamine (IPTp-SP) in pregnancy is threatened in parts of Africa by the emergence and spread of resistance to SP. Intermittent screening with a rapid diagnostic test (RDT) and treatment of positive women (ISTp) is an alternative approach.Methods and Findings
An open, individually randomized, non-inferiority trial of IPTp-SP versus ISTp was conducted in 5,354 primi- or secundigravidae in four West African countries with a low prevalence of resistance to SP (The Gambia, Mali, Burkina Faso and Ghana). Women in the IPTp-SP group received SP on two or three occasions whilst women in the ISTp group were screened two or three times with a RDT and treated if positive for malaria with artemether-lumefantrine (AL). ISTp-AL was non-inferior to IPTp-SP in preventing low birth weight (LBW), anemia and placental malaria, the primary trial endpoints. The prevalence of LBW was 15.1% and 15.6% in the IPTp-SP and ISTp-AL groups respectively (OR = 1.03 [95% CI: 0.88, 1.22]). The mean hemoglobin concentration at the last clinic attendance before delivery was 10.97g/dL and 10.94g/dL in the IPTp-SP and ISTp-AL groups respectively (mean difference: -0.03 g/dL [95% CI: -0.13, +0.06]). Active malaria infection of the placenta was found in 24.5% and in 24.2% of women in the IPTp-SP and ISTp-AL groups respectively (OR = 0.95 [95% CI 0.81, 1.12]). More women in the ISTp-AL than in the IPTp-SP group presented with malaria parasitemia between routine antenatal clinics (310 vs 182 episodes, rate difference: 49.4 per 1,000 pregnancies [95% CI 30.5, 68.3], but the number of hospital admissions for malaria was similar in the two groups.Conclusions
Despite low levels of resistance to SP in the study areas, ISTp-AL performed as well as IPTp-SP. In the absence of an effective alternative medication to SP for IPTp, ISTp-AL is a potential alternative to IPTp in areas where SP resistance is high. It may also have a role in areas where malaria transmission is low and for the prevention of malaria in HIV positive women receiving cotrimoxazole prophylaxis in whom SP is contraindicated.Trial Registration
ClinicalTrials.gov NCT01084213 Pan African Clinical trials Registry PACT201202000272122 相似文献74.
Kevin Ostacolo Adrián López García de Lomana Clémence Larat Valgerdur Hjaltalin Kristrun Yr Holm Sigríður S. Hlynsdóttir Margaret Soucheray Linda Sooman Ottar Rolfsson Nevan J. Krogan Eirikur Steingrimsson Danielle L. Swaney Margret H. Ogmundsdottir 《Traffic (Copenhagen, Denmark)》2024,25(4):e12933
Macroautophagy/autophagy is an essential catabolic process that targets a wide variety of cellular components including proteins, organelles, and pathogens. ATG7, a protein involved in the autophagy process, plays a crucial role in maintaining cellular homeostasis and can contribute to the development of diseases such as cancer. ATG7 initiates autophagy by facilitating the lipidation of the ATG8 proteins in the growing autophagosome membrane. The noncanonical isoform ATG7(2) is unable to perform ATG8 lipidation; however, its cellular regulation and function are unknown. Here, we uncovered a distinct regulation and function of ATG7(2) in contrast with ATG7(1), the canonical isoform. First, affinity-purification mass spectrometry analysis revealed that ATG7(2) establishes direct protein–protein interactions (PPIs) with metabolic proteins, whereas ATG7(1) primarily interacts with autophagy machinery proteins. Furthermore, we identified that ATG7(2) mediates a decrease in metabolic activity, highlighting a novel splice-dependent function of this important autophagy protein. Then, we found a divergent expression pattern of ATG7(1) and ATG7(2) across human tissues. Conclusively, our work uncovers the divergent patterns of expression, protein interactions, and function of ATG7(2) in contrast to ATG7(1). These findings suggest a molecular switch between main catabolic processes through isoform-dependent expression of a key autophagy gene. 相似文献
75.
Plant and Soil - Vegetation stabilizes slopes via root mechanical reinforcement and hydrologic reinforcement induced by transpiration. Most studies have focused on mechanical reinforcement and its... 相似文献
76.
Elisabeth Balstad Magnussen Lars Johan Vatten Tom Ivar Lund-Nilsen Kjell ?smund Salvesen George Davey Smith P?l Richard Romundstad 《BMJ (Clinical research ed.)》2007,335(7627):978
Objective To examine the effect of cardiovascular risk factors before pregnancy on risk of pre-eclampsia.Design Population based prospective study.Setting Linkage between a Norwegian population based study (Nord-Trøndelag health study, HUNT-2) and Norway''s medical birth registry.Participants 3494 women who gave birth after participating in the Nord-Trøndelag health study at baseline; of whom 133 (3.8%) delivered after a pre-eclamptic pregnancy.Main outcome measure Odds ratio of developing pre-eclampsia.Results After adjustment for smoking; previous pre-eclampsia; parity; maternal age, education, and socioeconomic position; and duration between baseline measurements and delivery, positive associations were found between prepregnancy serum levels of triglycerides, cholesterol, low density lipoprotein cholesterol, non-high density lipoprotein cholesterol, and blood pressure and risk of pre-eclampsia. The odds ratio of developing pre-eclampsia for women with baseline systolic blood pressures greater than 130 mm Hg (highest fifth) was 7.3 (95% confidence interval 3.1 to 17.2) compared with women with systolic blood pressures less than 111 mm Hg (lowest fifth). Similar results were found for nulliparous and parous women. Women who used oral contraceptives at baseline had half the risk of pre-eclampsia compared with never or former users (0.5, 0.3 to 0.9).Conclusion Women with cardiovascular risk factors may be predisposed to pre-eclampsia. 相似文献
77.
Óskar Sindri Gíslason Halldór P. Halldórsson Marinó F. Pálsson Snæbjörn Pálsson Brynhildur Davíðsdóttir Jörundur Svavarsson 《Biological invasions》2014,16(9):1865-1877
With the increase in global oceanic trade the establishment of non-indigenous marine organisms has become a major environmental and economic problem worldwide. Recently, the Atlantic rock crab (Cancer irroratus) was reported in Icelandic waters, Eastern North Atlantic. This is the first record of this relatively large crab species outside its natural range, i.e. the east coast of North America. The crab was most likely transferred to Iceland as larvae in ballast water and has successfully established a reproducing population in Icelandic waters. The species is distributed along the southwestern- and western-coast of Iceland. Adult specimens are now common in Faxaflói Bay, Southwest Iceland, but with sporadic occurrences in western and northwestern Icelandic waters. The green crab (Carcinus maenas) and the spider crab (Hyas araneus) are the only native brachyuran decapod species commonly found in its new habitat, but despite its recent colonization the rock crab was the most abundant brachyuran in the areas studied in southwest Iceland. Egg bearing rock crab and green crab females were found from June to October, while egg bearing spider crab females were seen from July to December. In Southwest Iceland both rock crab and green crab larvae were abundant in mid-summer but rare in both spring and autumn, which is opposite of what was observed for the spider crab. The size and abundance of adult crabs, their reproductive conditions, and occurrence of all larval stages, indicate that the Atlantic rock crab has successfully colonized Iceland. 相似文献
78.
Ragnheiður Fossdal Magnus Böðarsson Páll Ásmundsson Jóhann Ragnarsson Dorien Peters Martijn H. Breuning Ólafur Jensson 《Human genetics》1993,91(6):609-613
We have mainly used 3 highly polymorphic DNA markers, 3HVR (D16S85), 16AC2.5 (D16S291) and SM7 (D16S283), flanking the PKD1 region on chromosome 16p13.3 to establish linkage status in seven Icelandic families with autosomal dominant polycystic kidney disease (ADPKD). In four families, the disease locus is in the PKD1 region, and three families are unlinked to chromosome 16p13.3. In one of the unlinked families, the disease locus is excluded from a part of the long arm of chromosome 2, and we support a theory of more than 2 loci being responsible for ADPKD. Our data confirm the location of the locus YNH24 (D2S44) to chromosome 2q13-q24. 相似文献
79.
S. Magnussen 《TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik》1993,86(2-3):349-355
Summary A central problem in the analysis of genetic field trials is the dichotomy of genetic and environmental effects because one cannot be defined without the other. Results from 768,000 simulated family trials in complete randomized block designs demonstrated a serious upward bias in estimates of family variance components from multi-unit plot designs when the phenotypic observations were compatible with a first-order autoregressive (AR1) process. The inflation of family variances and, thus, additive genetic variance and narrow sense individual heritabilities progressed exponentially with an increase in the nearest neighbor correlation () in the AR1 process. Significant differences in inflation rates persisted among various plot configurations. At = 0.2 the inflation of family variances reached 48–73%. Inflation rates were independent of the level of heritability. Modified Papadakis nearest neighbor (NN) adjustment procedures were tested for their ability to remove the bias in family variances. A NN-adjustment based on Mead's coefficient of interplant interaction and one derived from Bartlett's simultaneous autoregressive scheme removed up to 97% of the bias introduced by the phenotypic correlations. NN-adjusted estimates had slightly (5–8%) higher relative errors than did unadjusted estimates. 相似文献
80.
S. Magnussen 《TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik》1991,82(3):305-312
Summary Simultaneous improvement of several, and often negatively correlated, traits is frequently a desired objective in forest tree breeding. A profit function that includes a combination of both linear weights and weights for the cross-products of trait combinations facilitates the construction of a linear index, with an attractive response in all traits. A detailed algorithm for finding the index coefficients is provided, along with three examples of applications in tree breeding. The index is also a powerful tool in optimizing the selection for a ratio of two traits. It is argued that a more equal progress in several traits provides a safetey net when faced with economic uncertainties. The provided algorithm eliminates the need for direct search techniques. Existence of a dual set of linear weights means that the statistical properties of the index based on nonlinear profit functions are identical to those of the classical Smith-Hazel type of index. 相似文献