Stability of the immunogenic properties of plague vaccine strain EV, Research Institute of Epidemiology and Hygiene line, during long-term storage]

The experiments in guinea pigs showed that the immunogenic properties of plague vaccine strain EV, line NIIEG, freeze-dried in 1947 and stored under vacuum without animalization, remained unchanged for 30 years. The subcultures prepared from this train showed, after three passages in guinea pigs, good immunogenic properties which preserved for 6--10 years (the term of observation). After 30-years storage the stock culture of strain EV, line NIIEG, can be used for the preparation of NIIS live plague vaccine.     

A “microscopic” model of complexation between intercalators and DNA: Analysis of NMR spectroscopy data

A model is proposed for intercalation of ligands into an arbitrary oligonucleotide sequence, which makes allowance in explicit form for the microscopic constants and parameters of cooperative binding to particular sites of oligomer. The model is adapted for analysis of NMR spectroscopy data.