全文获取类型
收费全文 | 871篇 |
免费 | 63篇 |
出版年
2023年 | 6篇 |
2022年 | 8篇 |
2021年 | 17篇 |
2020年 | 14篇 |
2019年 | 16篇 |
2018年 | 12篇 |
2017年 | 9篇 |
2016年 | 29篇 |
2015年 | 44篇 |
2014年 | 39篇 |
2013年 | 39篇 |
2012年 | 61篇 |
2011年 | 65篇 |
2010年 | 49篇 |
2009年 | 46篇 |
2008年 | 44篇 |
2007年 | 36篇 |
2006年 | 36篇 |
2005年 | 33篇 |
2004年 | 42篇 |
2003年 | 33篇 |
2002年 | 35篇 |
2001年 | 15篇 |
2000年 | 17篇 |
1999年 | 16篇 |
1998年 | 8篇 |
1997年 | 7篇 |
1996年 | 10篇 |
1995年 | 5篇 |
1994年 | 5篇 |
1993年 | 7篇 |
1992年 | 16篇 |
1991年 | 13篇 |
1990年 | 14篇 |
1989年 | 9篇 |
1988年 | 8篇 |
1987年 | 5篇 |
1986年 | 7篇 |
1985年 | 6篇 |
1984年 | 5篇 |
1983年 | 5篇 |
1981年 | 4篇 |
1980年 | 3篇 |
1979年 | 4篇 |
1975年 | 3篇 |
1974年 | 6篇 |
1973年 | 4篇 |
1969年 | 3篇 |
1968年 | 3篇 |
1967年 | 3篇 |
排序方式: 共有934条查询结果,搜索用时 265 毫秒
931.
932.
Evgenia Deryusheva Ekaterina Nemashkalova Marie Galloux Charels‐Adrien Richard Jean‐Franois Elouët Denis Kovacs Karo Van Belle Peter Tompa Vladimir Uversky Sergei Permyakov 《Proteomics》2019,19(6)
Intrinsically disordered proteins (IDPs) are implicated in a range of human diseases, some of which are associated with the ability to bind to lipids. Although the presence of solvent‐exposed hydrophobic regions in IDPs should favor their interactions with low‐molecular‐weight hydrophobic/amphiphilic compounds, this hypothesis has not been systematically explored as of yet. In this study, the analysis of the DisProt database with regard to the presence of lipid‐binding IDPs (LBIDPs) reveals that they comprise, at least, 15% of DisProt entries. LBIDPs are classified into four groups by ligand type, functional categories, domain structure, and conformational state. 57% of LBIDPs are classified as ordered according to the CH‐CDF analysis, and 70% of LBIDPs possess lengths of disordered regions below 50%. To investigate the lipid‐binding properties of IDPs for which lipid binding is not reported, three proteins from different conformational groups are rationally selected. They all are shown to bind linoleic (LA) and oleic (OA) acids with capacities ranging from 9 to 34 LA/OA molecules per protein molecule. The association with LA/OA causes the formation of high‐molecular‐weight lipid–protein complexes. These findings suggest that lipid binding is common among IDPs, which can favor their involvement in lipid metabolism. 相似文献
933.
The melting of base pairs is a ubiquitous feature of RNA structural transitions, which are widely used to sense and respond to cellular stimuli. A recent study employing solution nuclear magnetic resonance (NMR) imino proton exchange spectroscopy provides a rare base-pair-specific view of duplex melting in the Salmonella FourU RNA thermosensor, which regulates gene expression in response to changes in temperature at the translational level by undergoing a melting transition. The authors observe “microscopic” enthalpy–entropy compensation—often seen “macroscopically” across a series of related molecular species—across base pairs within the same RNA. This yields variations in base-pair stabilities that are an order of magnitude smaller than corresponding variations in enthalpy and entropy. A surprising yet convincing link is established between the slopes of enthalpy–entropy correlations and RNA melting points determined by circular dichroism (CD), which argues that unfolding occurs when base-pair stabilities are equalized. A single AG-to-CG mutation, which enhances the macroscopic hairpin thermostability and folding cooperativity and renders the RNA thermometer inactive in vivo, spreads its effect microscopically throughout all base pairs in the RNA, including ones far removed from the site of mutation. The authors suggest that an extended network of hydration underlies this long-range communication. This study suggests that the deconstruction of macroscopic RNA unfolding in terms of microscopic unfolding events will require careful consideration of water interactions. 相似文献
934.