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排序方式: 共有126条查询结果,搜索用时 15 毫秒
31.
Evdokimova AG Radzevich AÉ Tomova AV Evdokimov VV Kovalenko EV Zhukolenko LV 《Antibiotiki i khimioterapii͡a》2011,56(5-6):64-68
Clinical efficacy of combined therapy including the use of rifaximin and L-ornithin-l-aspartate, as well as the dynamics of the biochemical indices, the manifestation levels of portal-systemic-encephalopathy and intestinal microbiocynosis were investigated in patients with chronic cardiac insufficiency of ischemic genesis and hobnail liver. The combined therapy resulted in improvement of the patients clinical state, lower levels of the portal-systemic encephalopathy manifectation by decreasing hyperammonium, normalization of the large intestine microflora, and blood serum biochemical parameters. 相似文献
32.
Pushkov AA Blagodatskikh KA Nikitin AG Agapkina IuV Brovkin AN Chudakova DA Evdokimova MA Aseĭcheva OIu Osmolovskaia VS Minushkina LO Baklanova TN Talyzin PA Donetskaia OP Tereshchenko SN Dzhaiani NA Akatova EA Glezer MG Galiavich AS Zakirova VB Koziolova NA Iagoda AV Boeva OI Horolets EV Shlyk SV Volkova EG Margarian MP Guz' IO Konstantinov VO Sidorenko BA Zateĭshchikov DA Nosikov VV 《Genetika》2011,47(10):1386-1392
The polymorphic markers Ala455Val of the THBD gene and Arg353Gln of the F7 gene were tested for association with the frequency of unfavorable outcomes in patients with a history of acute ischemic heart disease. The study involved 1145 patients hospitalized in cardiology clinics of Moscow, St. Petersburg, Kazan, Chelyabinsk, Perm, Stavropol, and Rostov-on-Don because of acute ischemic heart disease. The patients were followed up for up to 62.5 months. None of the markers displayed a significant association with the time to an endpoint. The patients were then grouped by sex. In females, the frequency of unfavorable outcomes (fatal or nonfatal myocardial infarction and fatal or nonfatal stroke) was higher in carriers of allele Val of the Ala344Val polymorphic marker of the THBD gene and carriers of genotype Arg/Arg of the Arg353Gln polymorphic marker of the F7 gene, but the difference was not statistically significant. Such an increase in frequency was not observed in males. To study the combined effect of the polymorphic markers of the THBD and F7 genes, the course of ischemic heart disease was compared for two female subgroups. One included carriers of allele Val of the Ala344Val polymorphic marker of the THBD gene and genotype Arg/Arg of the Arg353Gln polymorphic marker of the F7 gene; the other subgroup included carriers ofgenotype Ala/Ala of the Ala455Val polymorphic marker of the THBD gene and allele Gln of the Arg353Gln polymorphic marker of the F7 gene. The frequency of unfavorable outcomes in the first subgroup was higher than in the second one. The time to an endpoin was 40.5 months (95% confidence interval (CI) 33.5-47.6) in the first subgroup and 51.6 months (95% CI 45.0-58.1) in the second subgroup (chi2 = 4.15, P = 0.042). The results made it possible to assume that the F7 and THBD genes play an important role in genetic predisposition to unfavorable outcomes in patients with a history of acute ischemic heart disease. 相似文献
33.
The study was undertaken to improve ultrasonography using needle biopsy under ultrasound control in the diagnosis of pleurisies of various etiologies. The patients of the Department of Thoracic Surgery, who had been divided by the nosological principle (nonspecific pleurisy, tuberculosis effusions, and tumorous and posttraumatic pleurisies), were followed up. The study and statistical processing yielded major ultrasound criteria for pleural effusions and a final diagnosis was made on the basis of needle biopsy under ultrasound control with subsequent morphological verification. 相似文献
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We studied the contents of flavonols (kaempferol and quercetin) in the meristem of vegetative and generative apices of the main plant shoot in floral Papaver somniferum L. mutants, as well as in the normal plants at successive stages of flower development. Five stages of flower development were distinguished. Flavonols (kaempferol and quercetin) were present in all flower organs at all stages of floral morphogenesis we studied. However, their contents and distribution in different organs and at different stages of flower development markedly varied. No significant differences were found in the contents of flavonols in the meristems of vegetative and generative apices of the main shoot in the lines of floral mutants, as well as between the lines with different amounts of vegetative phytomeres. In the plants with normal flower structure, the contents of flavonols (kaempferol + quercetin) sharply increased with the beginning of differentiation of flower organs, i.e. from stage 3, to reach a maximum in the open flower, when gametogenesis is terminated and fertilization takes place. The level of flavonol contents in the petals (upper part) and stamen was at a maximum at all stages of flower development, while that in the gynaecium was at a minimum. The kaempferol : quercetin ratio was shifted towards quercetin at successive stages of flower development, most significantly in the stamens. The involvement of flavonols in the regulation of floral morphogenesis at stages of flower organs differentiation and functioning is discussed. 相似文献
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I G Tiganova N M Evdokimova G I Aleshkin 《Molekuliarnaia genetika, mikrobiologiia i virusologiia》1988,(4):44-48
The effect of UV-irradiation on Vibrio cholerae cells and its changes mediated by the plasmid R245 have been studied. Vibrio cholerae strains 569B and RV31 have been shown to be considerably more sensitive to lethal effect of UV-irradiation as compared with Escherichia coli and Salmonella typhimurium cells. Highly toxigenic strain 569B and practically atoxigenic strain RV31 have the same UV-sensitivity. Lethal effect of UV-irradiation on Vibrio cholerae cells is increased when the irradiated cells are plated on enriched media. UV-induction of mutations was not registered in plasmidless strains of Vibrio cholerae. Plasmid R245 increases UV-resistance of vibrio cells and makes them UV-mutable. 相似文献
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The survival of bacteria was studied in the "Artificial Mars" apparatus reproducing a complex of physical extreme factors. Bacteria isolated from microbiocenoses subjected to the action of chemical extreme factors (hydrogen peroxide, catalytically active minerals) were shown to be most resistant among soil heterotrophic bacteria. Cells in the resting state caused by dehydration survived better than vegetative cells. It has been concluded that microorganisms quite different in their physiological requirements and ecological properties can exist in the habitats extreme for life conditions. 相似文献