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31.
We studied the effects of methanol, ethanol, iso-propanol, and n-propanol on the reaction of hemoglobin with oxygen at various temperatures. The analysis of the results in terms of the Monod-Wyman-Changeux model allowed determination of the overall contribution of the alcohols to the standard enthalpy and entropy differences between the T and R states of hemoglobin. A phenomenological approach allowed us to obtain separately the contributions related to the variations of the bulk dielectric constant of the solvent (bulk electrostatic contributions) and the contributions related to other effects (non-bulk-electrostatic contributions). The values of non-bulk-electrostatic contributions to ΔΔH and ΔΔS supported the suggestion that these contributions are mainly related to protein-solvent hydrophobic interactions. 相似文献
32.
Inositol deficiency in Saccharomyces cerevisiae NCYC 86 总被引:1,自引:1,他引:0
When Saccharomyces cerevisiae NCYC 86, an inositol dependent strain, is grown at suboptimal concentrations of inositol, the buds are apparently unable to separate from the parent cells. Thin sections of such cells show an irregularly thickened cell wall. These morphological features may be due to a continuation or increase in the production of glucan while the synthesis of DNA, RNA, phospholipids and protein is greatly inhibited. 相似文献
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Luis E. Escobar Sandra Pritzkow Steven N. Winter Daniel A. Grear Megan S. Kirchgessner Ernesto Dominguez‐Villegas Gustavo Machado A. Townsend Peterson Claudio Soto 《Biological reviews of the Cambridge Philosophical Society》2020,95(2):393-408
Prions are misfolded infectious proteins responsible for a group of fatal neurodegenerative diseases termed transmissible spongiform encephalopathy or prion diseases. Chronic Wasting Disease (CWD) is the prion disease with the highest spillover potential, affecting at least seven Cervidae (deer) species. The zoonotic potential of CWD is inconclusive and cannot be ruled out. A risk of infection for other domestic and wildlife species is also plausible. Here, we review the current status of the knowledge with respect to CWD ecology in wildlife. Our current understanding of the geographic distribution of CWD lacks spatial and temporal detail, does not consider the biogeography of infectious diseases, and is largely biased by sampling based on hunters' cooperation and funding available for each region. Limitations of the methods used for data collection suggest that the extent and prevalence of CWD in wildlife is underestimated. If the zoonotic potential of CWD is confirmed in the short term, as suggested by recent results obtained in experimental animal models, there will be limited accurate epidemiological data to inform public health. Research gaps in CWD prion ecology include the need to identify specific biological characteristics of potential CWD reservoir species that better explain susceptibility to spillover, landscape and climate configurations that are suitable for CWD transmission, and the magnitude of sampling bias in our current understanding of CWD distribution and risk. Addressing these research gaps will help anticipate novel areas and species where CWD spillover is expected, which will inform control strategies. From an ecological perspective, control strategies could include assessing restoration of natural predators of CWD reservoirs, ultrasensitive CWD detection in biotic and abiotic reservoirs, and deer density and landscape modification to reduce CWD spread and prevalence. 相似文献
35.
Gemma Aragonès Kalavathi Dasuri Opeoluwa Olukorede Sarah G. Francisco Carol Renneburg Caroline Kumsta Malene Hansen Shun Kageyama Masaaki Komatsu Sheldon Rowan Jonathan Volkin Michael Workman Wenxin Yang Paula Daza Diego Ruano Helena Dominguez‐Martín José Antonio Rodríguez‐Navarro Xue‐Liang Du Michael A. Brownlee Eloy Bejarano Allen Taylor 《Aging cell》2020,19(11)
36.
Olga P. Nyssen Angeles Perez‐Aisa Luis Rodrigo Manuel Castro Pilar Mata Romero Juan Ortuo Jesus Barrio Jose Maria Huguet Ines Modollel Noelia Alcaide Alfredo Lucendo Xavier Calvet Monica Perona Barbara Gomez Blas Jose Gomez Rodriguez Pilar Varela Manuel Jimenez‐Moreno Manuel Dominguez‐Cajal Liliana Pozzati Diego Burgos Luis Bujanda Jenifer Hinojosa Javier Molina‐Infante Tommaso Di Maira Luis Ferrer Luis Fernndez‐Salazar Ariadna Figuerola Llucia Tito Cristobal de la Coba Judith Gomez‐Camarero Nuria Fernandez Maria Caldas Ana Garre Elena Resina Ignasi Puig Colm OMorain Francis Megraud Javier P. Gisbert 《Helicobacter》2020,25(5)
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Muhammad Zareef Rashid Iqbal Neira Gamboa De Dominguez Juan Rodrigues Javid H. Zaidi Muhammad Arfan 《Journal of enzyme inhibition and medicinal chemistry》2013,28(3):301-308
A series of new benzenesulfonamides, most of which are chiral, incorporating 1, 3, 4-oxadiazole and amino acid moieties have been synthesized. Some of these compounds were screened for antimalarial activity and also evaluated for their ability to inhibit hem polymerization. The electrophoretic analysis indicated that one compound was effective in inhibiting the degradation of hemoglobin. The synthesized compounds were tested in mice infected with Plasmodium berghei. These derivatives have the potential for the development of novel antimalarial lead compounds. 相似文献
39.
J. M. Fraile J. G. Puig Rosa J. Torres Eugenio de Miguel Pedro Martínez J. J. Vázquez 《Nucleosides, nucleotides & nucleic acids》2013,32(4-6):330-334
Forty-four patients (40 males) with a mean age of 58 years were included in this pilot study. Mean serum urate concentration in patients with and without the metabolic syndrome (MS) was 8.8 mg/dL and 8.1 mg/dL, respectively. Urinary uric acid excretion was 543 mg/day/1.73m2 in the former and 609 mg/day/1.73m2 in the latter. Uric acid to creatinine ratio was 0.37 mg/mg in patients with the MS and 0.42 mg/mg in those without the MS. Mean serum urate increased from 8.6 mg/dL in subjects with three or more MS components to 10.3 mg/dL in those with five MS components. Serum urate was markedly lower in patients with mild MS (9 patients, 8.6 mg/dL) as compared to severe MS (10 patients, 9.2 mg/dL). In contrast, urinary uric acid to creatinine ratio was 0.42 mg/mg in patients with gout and mild MS and 0.33 mg/mg in gout patients with severe MS. Uric acid underexcretion appears to be more severe in gout patients with the MS. This disturbance appears to be related to the severity of the MS. 相似文献