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Tipin/Tim1/And1 protein complex promotes Polα chromatin binding and sister chromatid cohesion 下载免费PDF全文
Alessia Errico Claudia Cosentino Teresa Rivera Ana Losada Etienne Schwob Tim Hunt Vincenzo Costanzo 《The EMBO journal》2009,28(23):3681-3692
The Tipin/Tim1 complex plays an important role in the S‐phase checkpoint and replication fork stability. However, the biochemical function of this complex is poorly understood. Using Xenopus laevis egg extract we show that Tipin is required for DNA replication in the presence of limiting amount of replication origins. Under these conditions the DNA replication defect correlates with decreased levels of DNA Polα on chromatin. We identified And1, a Polα chromatin‐loading factor, as new Tipin‐binding partner. We found that both Tipin and And1 promote stable binding of Polα to chromatin and that this is required for DNA replication under unchallenged conditions. Strikingly, extracts lacking Tipin and And1 also show reduced sister chromatids cohesion. These data indicate that Tipin/Tim1/And1 form a complex that links stabilization of replication fork and establishment of sister chromatid cohesion. 相似文献
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Virginie Lopez Rascol Anthony Levasseur Olivier Chabrol Simona Grusea Philippe Gouret Etienne GJ Danchin Pierre Pontarotti 《BMC bioinformatics》2009,10(1):284
Background
Understanding genome evolution provides insight into biological mechanisms. For many years comparative genomics and analysis of conserved chromosomal regions have helped to unravel the mechanisms involved in genome evolution and their implications for the study of biological systems. Detection of conserved regions (descending from a common ancestor) not only helps clarify genome evolution but also makes it possible to identify quantitative trait loci (QTLs) and investigate gene function. 相似文献908.
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Etienne Challet 《Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology》2010,180(5):631-644
Daily variations in behaviour and physiology are controlled by a circadian timing system consisting of a network of oscillatory
structures. In mammals, a master clock, located in the suprachiasmatic nuclei (SCN) of the hypothalamus, adjusts timing of
other self-sustained oscillators in the brain and peripheral organs. Synchronisation to external cues is mainly achieved by
ambient light, which resets the SCN clock. Other environmental factors, in particular food availability and time of feeding,
also influence internal timing. Timed feeding can reset the phase of the peripheral oscillators whilst having almost no effect
in shifting the phase of the SCN clockwork when animals are exposed (synchronised) to a light–dark cycle. Food deprivation
and calorie restriction lead not only to loss of body mass (>15%) and increased motor activity, but also affect the timing
of daily activity, nocturnal animals becoming partially diurnal (i.e. they are active during their usual sleep period). This
change in behavioural timing is due in part to the fact that metabolic cues associated with calorie restriction affect the
SCN clock and its synchronisation to light. 相似文献