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991.
992.
Gravante G Delogu D Esposito G Montone A 《Plastic and reconstructive surgery》2007,120(1):362; author reply 362-362; author reply 363
993.
Cardozo Paula Di Palma Albana Martin Soledad Cerliani Cecilia Esposito Gabriel Reinoso Herminda Travaglia Claudia 《Journal of Plant Growth Regulation》2022,41(3):1032-1040
Journal of Plant Growth Regulation - Azospirillum brasilense is a plant growth promoting bacteria (PGPB) widely used as an inoculant in diverse species, including maize (Zea mays L.) to improve... 相似文献
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996.
PDZ Domain in the Engineering and Production of a Saporin Chimeric Toxin as a Tool for targeting Cancer Cells
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![点击此处可从《Journal of cellular biochemistry》网站下载免费的PDF全文](/ch/ext_images/free.gif)
997.
Maria Scuotto Elisa Rivieccio Alessia Varone Daniela Corda Mariarosaria Bucci Valentina Vellecco Giuseppe Cirino Antonella Virgilio Veronica Esposito Aldo Galeone Nicola Borbone Michela Varra Luciano Mayol 《Nucleic acids research》2015,43(16):7702-7716
Many antiproliferative G-quadruplexes (G4s) arise from the folding of GT-rich strands. Among these, the Thrombin Binding Aptamer (TBA), as a rare example, adopts a monomolecular well-defined G4 structure. Nevertheless, the potential anticancer properties of TBA are severely hampered by its anticoagulant action and, consequently, no related studies have appeared so far in the literature. We wish to report here that suitable chemical modifications in the TBA sequence can preserve its antiproliferative over anticoagulant activity. Particularly, we replaced one residue of the TT or TGT loops with a dibenzyl linker to develop seven new quadruplex-forming TBA based sequences (TBA-bs), which were studied for their structural (CD, CD melting, 1D NMR) and biological (fibrinogen, PT and MTT assays) properties. The three-dimensional structures of the TBA-bs modified at T13 (TBA-bs13) or T12 (TBA-bs12), the former endowed with selective antiproliferative activity, and the latter acting as potently as TBA in both coagulation and MTT assays, were further studied by 2D NMR restrained molecular mechanics. The comparative structural analyses indicated that neither the stability, nor the topology of the G4s, but the different localization of the two benzene rings of the linker was responsible for the loss of the antithrombin activity for TBA-bs13. 相似文献
998.
The morphology of photophores in the garrick,cyclothone braueri (Family: Gonostomatidae): an ultrastructure study
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Mauro Cavallaro Pietro Battaglia Rosaria Laurà Maria Cristina Guerrera Francesco Abbate Antonino Germanà 《Acta zoologica》2015,96(3):296-300
A contribution to the knowledge of the photophore structure of the mesopelagic fish Cyclothone braueri (Gonostomatidae) from the central Mediterranean Sea (Strait of Messina) is given by means of a structural and ultrastructural study, to better identify and classify the real anatomical structures costituing these luminous organs. The photocytes exhibit numerous secretory granules, of different electron density, embedded in an extremely developed rough endoplasmic reticulum. The lens appear to be composed of tightly contiguous polyhedral cells. The reflector is made up of cells rich in guanine crystals, embedded in an amorphous matrix and is surrounded by a layer of connective tissue containing melanocytes. Unlike the present knowledge, it is shown that the bioluminescence emitted from C. braueri light organs has glandular nature, with photophores similar to type α from Bassot classification. The phenomenon of adaptive convergence, documenting how the morphology and physiology of the light organs of teleosts is similar in different species despite their taxonomic distance, is confirmed also for C. braueri. 相似文献
999.
The determinants of bond angle variability in protein/peptide backbones: A comprehensive statistical/quantum mechanics analysis
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![点击此处可从《Proteins》网站下载免费的PDF全文](/ch/ext_images/free.gif)
The elucidation of the mutual influence between peptide bond geometry and local conformation has important implications for protein structure refinement, validation, and prediction. To gain insights into the structural determinants and the energetic contributions associated with protein/peptide backbone plasticity, we here report an extensive analysis of the variability of the peptide bond angles by combining statistical analyses of protein structures and quantum mechanics calculations on small model peptide systems. Our analyses demonstrate that all the backbone bond angles strongly depend on the peptide conformation and unveil the existence of regular trends as function of ψ and/or φ. The excellent agreement of the quantum mechanics calculations with the statistical surveys of protein structures validates the computational scheme here employed and demonstrates that the valence geometry of protein/peptide backbone is primarily dictated by local interactions. Notably, for the first time we show that the position of the Hα hydrogen atom, which is an important parameter in NMR structural studies, is also dependent on the local conformation. Most of the trends observed may be satisfactorily explained by invoking steric repulsive interactions; in some specific cases the valence bond variability is also influenced by hydrogen‐bond like interactions. Moreover, we can provide a reliable estimate of the energies involved in the interplay between geometry and conformations. Proteins 2015; 83:1973–1986. © 2015 Wiley Periodicals, Inc. 相似文献
1000.
Sante Roperto Valeria Russo Iolanda Esposito Dora Maria Ceccarelli Orlando Paciello Luigi Avallone Rosanna Capparelli Franco Roperto 《PloS one》2015,10(10)