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Shkelzen Shabani Bryan Schmidt Bikalpa Ghimire Sydney K. Houlton Laura Hellmuth Erika Mojica Tamara J. Phillips 《Genes, Brain & Behavior》2019,18(3)
Binge methamphetamine (MA) users have higher MA consumption, relapse rates and depression‐like symptoms during early periods of withdrawal, compared with non‐binge users. The impact of varying durations of MA abstinence on depression‐like symptoms and on subsequent MA intake was examined in mice genetically prone to binge‐level MA consumption. Binge‐level MA intake was induced using a multiple‐bottle choice procedure in which mice were offered one water drinking tube and three tubes containing increasing concentrations of MA in water, or four water tubes (control group). In two studies, depression‐like symptoms were measured using a tail‐suspension test and a subsequent forced‐swim test, after forced abstinence of 6 and 30 hours from a 28‐day course of chronic MA intake. An additional study measured the same depression‐like symptoms, as well as MA intake, after prolonged abstinence of 1 and 2 weeks. MA high drinking mice and one of their progenitor strains DBA/2J escalated their MA intake with increasing MA concentration; however, MA high drinking mice consumed almost twice as much MA as DBA/2J mice. Depression‐like symptoms were significantly higher early after MA access was withdrawn, compared to levels in drug‐naïve controls, with more robust effects of MA withdrawal observed in MA high drinking than DBA/2J mice. When depression‐like symptoms were examined after 1 or 2 weeks of forced abstinence in MA high drinking mice, depression‐like symptoms dissipated, and subsequent MA intake was high. The MA high drinking genetic mouse model has strong face validity for human binge MA use and behavioral sequelae associated with abstinence. 相似文献
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Andrea J. Reid Andrew K. Carlson Irena F. Creed Erika J. Eliason Peter A. Gell Pieter T. J. Johnson Karen A. Kidd Tyson J. MacCormack Julian D. Olden Steve J. Ormerod John P. Smol William W. Taylor Klement Tockner Jesse C. Vermaire David Dudgeon Steven J. Cooke 《Biological reviews of the Cambridge Philosophical Society》2019,94(3):849-873
In the 12 years since Dudgeon et al. (2006) reviewed major pressures on freshwater ecosystems, the biodiversity crisis in the world's lakes, reservoirs, rivers, streams and wetlands has deepened. While lakes, reservoirs and rivers cover only 2.3% of the Earth's surface, these ecosystems host at least 9.5% of the Earth's described animal species. Furthermore, using the World Wide Fund for Nature's Living Planet Index, freshwater population declines (83% between 1970 and 2014) continue to outpace contemporaneous declines in marine or terrestrial systems. The Anthropocene has brought multiple new and varied threats that disproportionately impact freshwater systems. We document 12 emerging threats to freshwater biodiversity that are either entirely new since 2006 or have since intensified: (i) changing climates; (ii) e‐commerce and invasions; (iii) infectious diseases; (iv) harmful algal blooms; (v) expanding hydropower; (vi) emerging contaminants; (vii) engineered nanomaterials; (viii) microplastic pollution; (ix) light and noise; (x) freshwater salinisation; (xi) declining calcium; and (xii) cumulative stressors. Effects are evidenced for amphibians, fishes, invertebrates, microbes, plants, turtles and waterbirds, with potential for ecosystem‐level changes through bottom‐up and top‐down processes. In our highly uncertain future, the net effects of these threats raise serious concerns for freshwater ecosystems. However, we also highlight opportunities for conservation gains as a result of novel management tools (e.g. environmental flows, environmental DNA) and specific conservation‐oriented actions (e.g. dam removal, habitat protection policies, managed relocation of species) that have been met with varying levels of success. Moving forward, we advocate hybrid approaches that manage fresh waters as crucial ecosystems for human life support as well as essential hotspots of biodiversity and ecological function. Efforts to reverse global trends in freshwater degradation now depend on bridging an immense gap between the aspirations of conservation biologists and the accelerating rate of species endangerment. 相似文献
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In Type 2 Diabetes Mellitus Glycated Albumin Alters Macrophage Gene Expression Impairing ABCA1‐Mediated Cholesterol Efflux
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Adriana Machado‐Lima Rodrigo T. Iborra Raphael S. Pinto Gabriela Castilho Camila H. Sartori Erika R. Oliveira Ligia S. Okuda Edna R. Nakandakare Daniel Giannella‐Neto Ubiratan F. Machado Maria Lucia C. Corrêa‐Giannella Pietro Traldi Simona Porcu Marco Roverso Annunziata Lapolla Marisa Passarelli 《Journal of cellular physiology》2015,230(6):1250-1257
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Fabio S. Lima Georgios Oikonomou Svetlana F. Lima Marcela L. S. Bicalho Erika K. Ganda Jose C. de Oliveira Filho Gustavo Lorenzo Plamen Trojacanec Rodrigo C. Bicalho 《Applied and environmental microbiology》2015,81(4):1327-1337
Microbes present in the rumen of dairy cows are essential for degradation of cellulosic and nonstructural carbohydrates of plant origin. The prepartum and postpartum diets of high-producing dairy cows are substantially different, but in what ways the rumen microbiome changes in response and how those changes may influence production traits are not well elucidated. Here, we sequenced the 16S and 18S rRNA genes using the MiSeq platform to characterize the prepartum and postpartum rumen fluid microbiomes in 115 high-producing dairy cows, including both primiparous and multiparous animals. Discriminant analysis identified differences between the microbiomes of prepartum and postpartum samples and between primiparous and multiparous cows. 18S rRNA sequencing revealed an overwhelming dominance of the protozoan class Litostomatea, with over 90% of the eukaryotic microbial population belonging to that group. Additionally, fungi were relatively more prevalent and Litostomatea relatively less prevalent in prepartum samples than in postpartum ones. The core rumen microbiome (common to all samples) consisted of 64 bacterial taxa, of which members of the genus Prevotella were the most prevalent. The Chao1 richness index was greater for prepartum multiparous cows than for postpartum multiparous cows. Multivariable models identified bacterial taxa associated with increased or reduced milk production, and general linear models revealed that a metagenomically based prediction of productivity is highly associated with production of actual milk and milk components. In conclusion, the structure of the rumen fluid microbiome shifts between the prepartum and first-week postpartum periods, and its profile within the context of this study could be used to accurately predict production traits. 相似文献
998.
Chemotype of tansy (Tanacetum vulgare L.) determines aphid genotype and its associated predator system
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Klára Benedek János Bálint Rozália Veronika Salamon Erika Kovács Beáta Ábrahám Csaba Fazakas Hugh D. Loxdale Adalbert Balog 《Biological journal of the Linnean Society. Linnean Society of London》2015,114(3):709-719
Field assessments and genetic analyses on tansy aphid, Metopeurum fuscoviride Stroyan were made aiming to investigate whether a specialist aphid species and its associated predator density differ between chemotypes of the plant host, tansy, and whether the essential oil composition of the plant host determines the genetic differences observed between colonies of M. fuscoviride inhabiting these different chemotypes. Tansy plants were defined after volatile extractions as Camphor Pure and Borneol Pure, respectively, with hybrid chemotypes defined as Camphor Hybrid, Borneol Hybrid, and Thujone Hybrid, respectively. Ladybird beetles, Coccinella septempunctata (L.), clearly dominated Pure Camphor plants, whereas significantly higher numbers of the nursery web spider, Pisaura mirabilis (Clerck), were detected on Borneol Pure and Borneol Hybrid plants. Genetic analyses using five polymorphic microsatellite markers revealed that higher genetic similarity existed between M. fuscoviride aphids from Borneol Pure and Borneol Hybrid plants and between Camphor Pure and Camphor Hybrid plants, respectively, whereas a lower level of genetic similarity was seen between these aphids from Thujone Hybrid plants. Accordingly, it is possible that host plant‐adapted species can create much context‐dependency in the nature and strength of predation effects, which may in turn alter costs and benefits of host plant chemical differentiations, or even the prey genotype variations. © 2014 The Linnean Society of London, Biological Journal of the Linnean Society, 2014, 114 , 709–719. 相似文献
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An increased knee abduction angle during jump-landing has been identified as a risk factor for anterior cruciate ligament injuries. Activation of the hip abductors may decrease the knee abduction angle during jump-landing. The purpose of this study was to examine the effects of a resistance band on the internal hip abduction moment and gluteus medius activation during the pre-landing (100 ms before initial contact) and early-landing (100 ms after initial contact) phases of a jump–landing–jump task. Thirteen male and 15 female recreational athletes (age: 21.1±2.4 yr; mass: 73.8±14.6 kg; height: 1.76±0.1 m) participated in the study. Subjects performed jump–landing–jump tasks with or without a resistance band applied to their lower shanks. During the with-band condition, subjects were instructed to maintain their movement patterns as performing the jump-landing task without a resistance band. Lower extremity kinematics, kinetics, and gluteus medius electromyography (EMG) were collected. Applying the band increased the average hip abduction moment during pre-landing (p<0.001, Cohen?s d (d)=2.8) and early-landing (p<0.001, d=1.5), and the average gluteus medius EMG during pre-landing (p<0.001, d=1.0) and early-landing (p=0.003, d=0.55). Applying the band decreased the initial hip flexion angle (p=0.028, d=0.25), initial hip abduction angle (p<0.001, d=0.91), maximum knee flexion angle (p=0.046, d=0.17), and jump height (p=0.004, d=0.16). Applying a resistance band provides a potential strategy to train the strength and muscle activation for the gluteus medius during jump-landing. Additional instructions and feedback regarding hip abduction, hip flexion, and knee flexion may be required to minimize negative changes to other kinematic variables. 相似文献