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231.
Tânia Salvaterra Dannielle S. Green Tasman P. Crowe Eoin J. O’Gorman 《Biological invasions》2013,15(11):2563-2576
Biological invasions have the potential to cause severe alterations to the biodiversity of natural ecosystems. At the same time, variation in the diversity and composition of native communities may have an important influence on the impact of invasions. Here, effects of the invasive Japanese wireweed, Sargassum muticum, were tested across a range of native marine algal assemblages using a combined additive and substitutive design. The invasive alga significantly reduced primary production, an important component of ecosystem functioning, and increased connectance, a key property of the food webs associated with the algal resources. These impacts were mediated by changes in the proportions of intermediate and top species, as well as apparent reductions in faunal species richness and diversity. Some key alterations to faunal species composition (including the arrival of generalist species associated with S. muticum) may have been important in determining these patterns. Overall results suggest that S. muticum not only directly impeded the native algal community, but that these effects extended indirectly to the native fauna and therefore caused major changes throughout the ecosystem. 相似文献
232.
Thomas J. Woltering Wolfgang Wostl Hans Hilpert Mark Rogers-Evans Emmanuel Pinard Alexander Mayweg Martin Göbel David W. Banner Jörg Benz Massimiliano Travagli Martina Pollastrini Guido Marconi Emanuele Gabellieri Wolfgang Guba Harald Mauser Matteo Andreini Helmut Jacobsen Eoin Power Robert Narquizian 《Bioorganic & medicinal chemistry letters》2013,23(14):4239-4243
A series of amides bearing a variety of amidine head groups was investigated as BACE1 inhibitors with respect to inhibitory activity in a BACE1 enzyme as well as a cell-based assay. Determination of their basicity as well as their properties as substrates of P-glycoprotein revealed that a 2-amino-1,3-oxazine head group would be a suitable starting point for further development of brain penetrating compounds for potential Alzheimer’s disease treatment. 相似文献
233.
McEvoy Eoin Deshpande Vikram S. McGarry Patrick 《Biomechanics and modeling in mechanobiology》2019,18(4):921-937
Biomechanics and Modeling in Mechanobiology - The active cytoskeleton is known to play an important mechanistic role in cellular structure, spreading, and contractility. Contractility is actively... 相似文献
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