The structural organization of calf retinal photoreceptors derived from freeze-fracture study

Freeze-fracturing and double replica technique provided some evidence that the membranes of the outer segment of calf retina are asymmetric. The intramembranous particles, probably consisting of rhodopsin, exposed by the fracture, are apparently more strongly anchored to one half of the bilayer. These results are consistent with the molecular model of disc membrane suggesting that rhodopsin is associated only with one side of the membrane.     

Stimulation of dopamine D-1 receptors by SKF 38393 induces EEG desynchronization and behavioral arousal

The dopamine D-1 receptor agonist SKF 38393 dose-dependently (2.5-10 mg/kg) induced desynchronization of the electroencephalographic (EEG) activity and behavioral arousal in both rabbits and rats. Unlike apomorphine, SKF 38393 elicited no signs of stereotyped behavior in rabbits and minimal effects, such as episodes of grooming, in rats. The effects of SKF 38393 10 mg/kg on the EEG were prevented by the selective D-1 receptor antagonist SCH 23390 at a dose as low as 0.003 mg/kg, but not by the D-2 antagonist (-)-sulpiride (25-50 mg/kg). These data provide evidence of a role of D-1 receptors in the generation of EEG activity related to behavioral arousal. In addition, this model is a valuable tool to functionally evaluate the D-1 antagonistic properties of neuroleptics.