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91.
92.
The male Laneella perisi (Mariluis) n. comb. is described based on specimens collected in the Cordillera Oriental (1,370–1,450 m asl), Florencia-Suaza, Caquetá, Colombia. A key to separate the two species of the genus Laneella and illustrations of the male genitalia and female abdomen, terminalia, and spermatheca are also presented. 相似文献
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Here we describe a pathological osteoderm from the crocodylomorph Diplocynodon hantoniensis (Bouldnor Formation, earliest Oligocene, Isle of Wight, United Kingdom). The specimen bears a porous, erosive branching channel that distorts the surface ornamentation and periosteum over 60% of the preserved dorsal surface area. We diagnose this condition as necrotizing dermatitis: a surficial bacterial or fungal infection that can penetrate the dermal layers to affect the underlaying penosteum of osteoderms. This condition has been previously reported for an extant tortoise and caiman; however, this is the first reported occurrence in the fossil record. 相似文献
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Alison M. Strack Ester Carballo-Jane Sheng-ping Wang Jiyan Xue Xiaoli Ping Lesley Ann McNamara Anil Thankappan Olga Price Michael Wolff T. J. Wu Douglas Kawka Michele Mariano Charlotte Burton Ching H. Chang Jing Chen John Menke Silvi Luell Emanuel I. Zycband Xinchun Tong Richard Raubertas Carl P. Sparrow Brian Hubbard John Woods Gary O'Neill M. Gerard Waters Ayesha Sitlani 《Journal of lipid research》2013,54(1):177-188
The use of nicotinic acid to treat dyslipidemia is limited by induction of a “flushing” response, mediated in part by the interaction of prostaglandin D2 (PGD2) with its G-protein coupled receptor, DP1 (Ptgdr). The impact of DP1 blockade (genetic or pharmacologic) was assessed in experimental murine models of atherosclerosis. In Ptgdr−/−ApoE−/− mice versus ApoE−/− mice, both fed a high-fat diet, aortic cholesterol content was modestly higher (1.3- to 1.5-fold, P < 0.05) in Ptgdr−/−ApoE−/− mice at 16 and 24 weeks of age, but not at 32 weeks. In multiple ApoE−/− mouse studies, a DP1-specific antagonist, L-655, generally had a neutral to beneficial effect on aortic lipids in the presence or absence of nicotinic acid treatment. In a separate study, a modest increase in some atherosclerotic measures was observed with L-655 treatment in Ldlr−/− mice fed a high-fat diet for 8 weeks; however, this effect was not sustained for 16 or 24 weeks. In the same study, treatment with nicotinic acid alone generally decreased plasma and/or aortic lipids, and addition of L-655 did not negate those beneficial effects. These studies demonstrate that inhibition of DP1, with or without nicotinic acid treatment, does not lead to consistent or sustained effects on plaque burden in mouse atherosclerotic models. 相似文献
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Georg Wolff Christoph Hagen Kay Grünewald Rainer Kaufmann 《Biology of the cell / under the auspices of the European Cell Biology Organization》2016,108(9):245-258
Correlative light and electron microscopy (CLEM) has become a powerful tool in life sciences. Particularly cryo‐CLEM, the combination of fluorescence cryo‐microscopy (cryo‐FM) permitting for non‐invasive specific multi‐colour labelling, with electron cryo‐microscopy (cryo‐EM) providing the undisturbed structural context at a resolution down to the Ångstrom range, has enabled a broad range of new biological applications. Imaging rare structures or events in crowded environments, such as inside a cell, requires specific fluorescence‐based information for guiding cryo‐EM data acquisition and/or to verify the identity of the structure of interest. Furthermore, cryo‐CLEM can provide information about the arrangement of specific proteins in the wider structural context of their native nano‐environment. However, a major obstacle of cryo‐CLEM currently hindering many biological applications is the large resolution gap between cryo‐FM (typically in the range of ~400 nm) and cryo‐EM (single nanometre to the Ångstrom range). Very recently, first proof of concept experiments demonstrated the feasibility of super‐resolution cryo‐FM imaging and the correlation with cryo‐EM. This opened the door towards super‐resolution cryo‐CLEM, and thus towards direct correlation of structural details from both imaging modalities. 相似文献
99.
Bedraggled, a putative transporter, influences the tissue polarity complex during the R3/R4 fate decision in the Drosophila eye
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The tissue polarity pathway is required for the establishment of epithelial polarity in a variety of vertebrate and invertebrate organs. Core tissue polarity proteins act in a dynamically regulated complex to direct the polarization of the Drosophila eye. We report the identification and characterization of bedraggled (bdg), a novel gene that regulates one output of the tissue polarity pathway--the establishment of the R3/R4 photoreceptor fates. bdg encodes a novel, putative transporter protein and interacts genetically with all of the core polarity genes to influence the specification of the R3 and R4 cell fates. Finally, bdg is required for both viability and the initial stages of imaginal disc development. 相似文献
100.
Davide Perini Marilena Meloni Kirsten Wolff Giorgio Binelli 《Conservation Genetics》2007,8(5):1263-1266
The hexaploid herbaceous species Primula glaucescens Moretti and Primula spectabilis Tratt. (2n = 6x = 66) are two endemics of the Italian Pre-Alps protected by national and international laws. In order to plan conservation
strategies for natural populations and to study the influence of the latest glaciation on them we developed a set of microsatellites
markers for the endangered Primula species: ten primer pairs allowed analysis of polymorphic disomic loci in P. glaucescens samples and seven of them also amplified polymorphic disomic markers in P. spectabilis.
Kirsten Wolff and Giorgio Binelli contributed equally to the paper 相似文献