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排序方式: 共有287条查询结果,搜索用时 15 毫秒
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Diab Kawthar A. Fahmy Maha A. Hassan Emad M. El-Toumy Sayed A. 《Molecular biology reports》2022,49(9):8439-8448
Molecular Biology Reports - In this study, two main research objectives were examined: (1) the cytotoxic and anticancer activities of the aqueous methanol extract from Acacia nilotica flowers on... 相似文献
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Behnaz Saidy Shreeya Kotecha Anna Butler Emad A. Rakha Ian O. Ellis Andrew R. Green Stewart G. Martin Sarah J. Storr 《Journal of cellular and molecular medicine》2021,25(11):5015-5024
Cyclic AMP–dependent protein kinase A (PKA) and protein phosphatase 1 (PP1) are proteins involved in numerous essential signalling pathways that modulate physiological and pathological functions. Both PP1 and PKA can be inhibited by dopamine- and cAMP-regulated phosphoprotein 32 kD (DARPP-32). Using immunohistochemistry, PKA and PP1 expression was determined in a large primary breast tumour cohort to evaluate associations between clinical outcome and clinicopathological criteria (n > 1100). In addition, mRNA expression of PKA and PP1 subunits was assessed in the METABRIC data set (n = 1980). Low protein expression of PKA was significantly associated with adverse survival of breast cancer patients; interestingly, this relationship was stronger in ER-positive breast cancer patients. PP1 protein expression was not associated with patient survival. PKA and PP1 subunit mRNA was also assessed; PPP1CA, PRKACG and PRKAR1B were associated with breast cancer–specific survival. In patients with high expression of DARPP-32, low expression of PP1 was associated with adverse survival when compared to high expression in the same group. PKA expression and PP1 expression are of significant interest in cancer as they are involved in a wide array of cellular processes, and these data indicate PKA and PP1 may play an important role in patient outcome. 相似文献
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Diab Kawthar A. Fahmy Maha A. Hassan Emad M. Hassan Zeinab M. Omara Enayat A. Abdel-Samie Negm S. 《Molecular biology reports》2020,47(3):1733-1749
Molecular Biology Reports - Black mulberry (Morus nigra) leaves is broadly used in traditional medicine worldwide. However, there are no scientific reports regarding testicular protection,... 相似文献
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Mady Emad Ibrahim Shafik D. Randhir Reena Abd El-Hakim Ahmed F. Randhir Timothy O. 《Molecular biology reports》2022,49(5):3863-3873
Molecular Biology Reports - Germplasm identification is an essential connection linking the conservation and exploitation of crop genetic resources in several plant breeding programs. This study... 相似文献