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241.
BackgroundRecent reports have shown that there are developmental changes in the
ventilatory response to hypercapnia in the rat. These are characterized
by an initial large response to carbon dioxide immediately after birth
followed by a decline with a trough at one week of age, followed by a
return in sensitivity. A second abnormality is seen at postnatal day 5
(P5) rats in that they cannot maintain the increase in frequency for 5
min of hypercapnia. In mice lacking GAD65 the release of GABA during
sustained synaptic activation is reduced. We hypothesized that this
developmental pattern would be present in the mouse which is also less
mature at birth and that GABA mediates this relative respiratory
depression.MethodsIn awake C57BL/6J and GAD65-/- mice the ventilatory response to 5%
carbon dioxide (CO2) was examined at P2, P4, P6, P7, P12.5, P14.5 and
P21.5, using body plethysmography.ResultsMinute ventilation (VE) relative to baseline during hypercapnia from P2
through P7 was generally less than from P12.5 onwards, but there was no
trough as in the rat. Breaking VE down into its two components showed
that tidal volume remained elevated for the 5 min of exposure to 5% CO2.
At P6, but not at other ages, respiratory frequency declined with time
and at 5 min was less that at 2 and 3 min. GAD65-/- animals at P6 showed
a sustained increase in respiratory rate for the five mins exposure to
CO2.ConclusionThese results show, that in contrast to the rat, mice do not show a
decline in minute ventilatory response to CO2 at one week of age.
Similiar to the rat at P5, mice at P6 are unable to sustain an increase
in CO2 induced respiratory frequency and GAD65 contributes to this fall
off. 相似文献
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