全文获取类型
收费全文 | 763篇 |
免费 | 42篇 |
出版年
2024年 | 3篇 |
2023年 | 7篇 |
2022年 | 5篇 |
2021年 | 12篇 |
2020年 | 10篇 |
2019年 | 16篇 |
2018年 | 11篇 |
2017年 | 16篇 |
2016年 | 28篇 |
2015年 | 57篇 |
2014年 | 42篇 |
2013年 | 54篇 |
2012年 | 64篇 |
2011年 | 54篇 |
2010年 | 37篇 |
2009年 | 44篇 |
2008年 | 48篇 |
2007年 | 43篇 |
2006年 | 43篇 |
2005年 | 33篇 |
2004年 | 29篇 |
2003年 | 31篇 |
2002年 | 25篇 |
2001年 | 9篇 |
2000年 | 4篇 |
1999年 | 4篇 |
1998年 | 8篇 |
1997年 | 5篇 |
1996年 | 6篇 |
1995年 | 3篇 |
1994年 | 7篇 |
1993年 | 2篇 |
1992年 | 5篇 |
1991年 | 6篇 |
1990年 | 8篇 |
1989年 | 2篇 |
1988年 | 3篇 |
1986年 | 1篇 |
1985年 | 1篇 |
1984年 | 1篇 |
1983年 | 6篇 |
1982年 | 2篇 |
1980年 | 2篇 |
1979年 | 1篇 |
1978年 | 1篇 |
1976年 | 3篇 |
1962年 | 1篇 |
1960年 | 1篇 |
1957年 | 1篇 |
排序方式: 共有805条查询结果,搜索用时 0 毫秒
801.
David M. Arana Daniel Prieto Elvira Román César Nombela Rebeca Alonso‐Monge Jesús Pla 《Microbial biotechnology》2009,2(3):308-320
Fungal infections are a serious health problem. In recent years, basic research is focusing on the identification of fungal virulence factors as promising targets for the development of novel antifungals. The wall, as the most external cellular component, plays a crucial role in the interaction with host cells mediating processes such as adhesion or phagocytosis that are essential during infection. Specific components of the cell wall (called PAMPs) interact with specific receptors in the immune cell (called PRRs), triggering responses whose molecular mechanisms are being elucidated. We review here the main structural carbohydrate components of the fungal wall (glucan, mannan and chitin), how their biogenesis takes place in fungi and the specific receptors that they interact with. Different model fungal pathogens are chosen to illustrate the functional consequences of this interaction. Finally, the identification of the key components will have important consequences in the future and will allow better approaches to treat fungal infections. 相似文献
802.
Matthijs Freudenthal Lars W. van den Hoek Ostende Elvira Martín-Suárez 《Geobios》2013,46(1-2):105-109
The time and mode of colonization of Gargano have been a subject of debate. Taking into account the temporal distribution of the ancestors of the Mikrotia fauna, a Late Tortonian age represents the best fit for the time of migration. How these animals reached the island is even harder to decide. In the past some scholars embraced rafting as an important mechanism enabling small mammals to reach the islands, whereas others rejected this hypothesis, considering it an improbable mode of colonization. The recent record of oceanic rafts indicates that rafting is indeed a very plausible method for small-sized animals to reach islands, and the most probable method for the colonization of Gargano. A polyphasic model, as proposed by Masini and colleagues, is rejected in the case of Gargano, as it is based on a misinterpretation of the adaptive radiations within the Mikrotia fauna. 相似文献
803.
804.
José M. Icardo Wai P. Wong Elvira Colvee Ai M. Loong Agustín G. Zapata Yuen K. Ip 《Cell and tissue research》2014,355(2):397-407
We describe the structure of the lympho-granulocytic tissue associated with the wall of the spiral valve of the African lungfish Protopterus annectens. The study was performed under freshwater conditions and after 6 months of aestivation. The lympho-granulocytic tissue consists of nodes surrounded by reticular tissue. The nodes are formed by an outer and an inner component separated by a thin collagenous layer. The outer component is a reticular-like tissue that contains two types of granulocytes, developing and mature plasma cells and melanomacrophage centres (MMCs). The inner component, the parenchyma, contains a meshwork of trabeculae and vascular sinusoids and shows dark and pale areas. The dark areas contain diffuse lymphoid tissue, with a large number of mitoses and plasma cell clusters. The pale areas contain a small number of macrophages and lymphocytes. Macrophages and sinus endothelial cells are filled with haemosiderin granules and appear to form part of the reticuloendothelial system of the lungfish. The reticular tissue houses granulocytes, plasma cells and MMCs and might serve for the housing and maturation of cells of the white series. After aestivation, the nodes undergo lymphocyte depletion, the suppression of mitosis, granulocyte invasion and the occurrence of cell death. By contrast, few histological changes occur in the reticular tissue. Whereas the nodes appear to be involved in lymphocyte proliferation and plasma cell maturation, the function of the reticular tissue remains obscure. 相似文献
805.
B. Elvira 《Journal of fish biology》1990,37(SA):231-232