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911.
Dominique Lesuisse André Malanda Jean-François Peyronel Yannick Evanno Patrick Lardenois Danielle De-Peretti Pierre-Yves Abécassis Pascal Barnéoud Pascale Brunel Marie-Claude Burgevin Céline Cegarra Florian Auger Amélie Dommergue Corinne Lafon Luc Even Joanna Tsi Thy Phuong Hieu Luc Antonio Almario Xavier Vigé 《Bioorganic & medicinal chemistry letters》2019,29(7):929-932
In the course of a programme aimed at identifying Nurr1/NOT agonists for potential treatment of Parkinson’s disease, a few hits from high throughput screening were identified and characterized. A combined optimization pointed to a very narrow and stringent structure activity relationship. A comprehensive program of optimization led to a potent and safe candidate drug displaying neuroprotective and anti-inflammatory activity in several in vitro and in vivo models. 相似文献
912.
Asensio N Cristobal-Azkarate J Dias PA Vea JJ Rodríguez-Luna E 《Folia primatologica; international journal of primatology》2007,78(3):141-153
The activity patterns and diet of howler monkeys (Alouatta palliata mexicana) were studied in 3 forest fragments in south-eastern Mexico: Playa Escondida (PLA), Agaltepec Island (AGA) and Arroyo Liza (LIZ). Intersite differences offered the opportunity to investigate the foraging adaptations of howler monkeys in response to population and habitat size. In the largest fragment (PLA), the howlers' diet was based on high-quality items (fruit and young leaves). In AGA, where the density of howlers was the highest, their diet was mostly folivorous with a marked exploitation of uncommon food items such as vines, lianas, shrubs and herbs. The dietary differences in AGA were accompanied by more time spent travelling and less time spent resting. Although LIZ was the smallest fragment and had a high howler density, the small group size and the use of energy-minimizing strategies (less time spent travelling and more time spent resting) probably allowed howlers to maintain a frugivorous diet. 相似文献
913.
Passive integrated transponder (PIT) technology was used to study the behaviour of fishes during the summer season in two
headwater streams of northeastern Portugal. A total of 71 PIT tags (12 mm long × 2.1 mm diameter) were surgically implanted
in 1+ stocked (39) and native (32) brown trout of two size classes (<20.0 and ≥20.0 cm). Eight independent antennae, connected to
a multi-point decoder (MPD reader) unit, were placed in different microhabitats, selected randomly every 3 days during the
observation period (29 August–9 September in Baceiro stream and 19 September–4 October in Sabor stream). The results confirmed
this method as a suitable, labour efficient tool to assess the movement and habitat use of sympatric stocked and native trout
populations. About 76.9% of stocked and 59.4% of native PIT tagged trouts were detected. Multivariate techniques (CCA, DFA
and classification tree) showed a separation in habitat use between the two sympatric populations. Stocked trout mainly used
the microhabitats located in the middle of the channel with higher depths and without cover. Furthermore, these fishes displayed
a greater mobility and a diel activity pattern different to native trout populations. 相似文献
914.
Bakali HM Herman MD Johnson KA Kelly AA Wieslander A Hallberg BM Nordlund P 《The Journal of biological chemistry》2007,282(27):19644-19652
The human lipid kinase family controls cell proliferation, differentiation, and tumorigenesis and includes diacylglycerol kinases, sphingosine kinases, and ceramide kinases. YegS is an Escherichia coli protein with significant sequence homology to the catalytic domain of the human lipid kinases. We have solved the crystal structure of YegS and shown that it is a lipid kinase with phosphatidylglycerol kinase activity. The crystal structure reveals a two-domain protein with significant structural similarity to a family of NAD kinases. The active site is located in the interdomain cleft formed by four conserved sequence motifs. Surprisingly, the structure reveals a novel metal binding site composed of residues conserved in most lipid kinases. 相似文献
915.
Palacios-Rodríguez Pablo González-Santoro Marco Amézquita Adolfo Brunetti Andrés E. 《Evolutionary ecology》2022,36(1):153-162
Evolutionary Ecology - Sexual dichromatism has provided important information for understanding sexual selection, but its link to reproductive success has received little attention. Poison frogs... 相似文献
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Elisabeth Vas Amélie Lescro?l Olivier Duriez Guillaume Boguszewski David Grémillet 《Biology letters》2015,11(2)
Unmanned aerial vehicles, commonly called drones, are being increasingly used in ecological research, in particular to approach sensitive wildlife in inaccessible areas. Impact studies leading to recommendations for best practices are urgently needed. We tested the impact of drone colour, speed and flight angle on the behavioural responses of mallards Anas platyrhynchos in a semi-captive situation, and of wild flamingos (Phoenicopterus roseus) and common greenshanks (Tringa nebularia) in a wetland area. We performed 204 approach flights with a quadricopter drone, and during 80% of those we could approach unaffected birds to within 4 m. Approach speed, drone colour and repeated flights had no measurable impact on bird behaviour, yet they reacted more to drones approaching vertically. We recommend launching drones farther than 100 m from the birds and adjusting approach distance according to species. Our study is a first step towards a sound use of drones for wildlife research. Further studies should assess the impacts of different drones on other taxa, and monitor physiological indicators of stress in animals exposed to drones according to group sizes and reproductive status. 相似文献
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Is drug insurance status an effect modifier in epidemiologic database studies? The case of maternal asthma and major congenital malformations
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