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Summary In a population sample from Southwestern Germany PGM1-phenotypes are determined. The gene frequencies fit well to those of Great Britain.Head: Prof. Dr. Dr. H. Baitsch
Supported by the Deutsche Forschungsgemeinschaft. 相似文献
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Marcus J. Edwards Nanakow A. Baiden Alexander Johs Stephen J. Tomanicek Liyuan Liang Liang Shi Jim K. Fredrickson John M. Zachara Andrew J. Gates Julea N. Butt David J. Richardson Thomas A. Clarke 《FEBS letters》2014
The X-ray crystal structure of Shewanella oneidensis OmcA, an extracellular decaheme cytochrome involved in mineral reduction, was solved to a resolution of 2.7 Å. The four OmcA molecules in the asymmetric unit are arranged so the minimum distance between heme 5 on adjacent OmcA monomers is 9 Å, indicative of a transient OmcA dimer capable of intermolecular electron transfer. A previously identified hematite binding motif was identified near heme 10, forming a hydroxylated surface that would bring a heme 10 electron egress site to ∼10 Å of a mineral surface. 相似文献
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Elke Scheibler Corinna Roschlau David Brodbeck 《International journal of biometeorology》2014,58(8):1769-1778
Time management of truly wild hamsters was investigated in their natural habitat in Alashan desert, Inner Mongolia, China during summer of 2009, 2010, and 2012. Duration of activity outside their burrows, duration of foraging walks, and nocturnal inside stays were analyzed with the aim to elucidate impact of moon, ambient, and soil temperature. Animal data were determined using radio frequency identification (RFID) technique; for that purpose, individuals were caught in the field and marked with passive transponders. Their burrows were equipped with integrated microchip readers and photosensors for the detection of movements into or out of the burrow. Lunar impact was analyzed based on moon phase (full, waning, new, and waxing moons) and moon disk size. A prolongation of aboveground activity was shown with increasing moon disk size (Spearman ρ?=?0.237; p?=?0.025) which was caused by earlier onsets (ρ?=?0.161; p?=?0.048); additionally, foraging walks took longer (Pearson r?=?0.037; p?=?0.037). Temperature of different periods of time was analyzed, i.e., mean of whole day, of the activity phase, minimum, and maximum. Moreover, this was done for the current day and the previous 3 days. Overall, increasing ambient and soil temperatures were associated with shortening of activity by earlier offsets of activity and shorter nocturnal stays inside their burrows. Most influential temperatures for activity duration were the maximum ambient temperature, 3 days before (stepwise regression analysis R?=?0.499; R 2?=?0.249; F?=?7.281; p?=?0.013) and soil temperature during activity phase, 1 day before (R?=?0.644; R 2?=?0.283; F?=?7.458; p?=?0.004). 相似文献
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Marijke De Bock Elke Decrock Nan Wang Mélissa Bol Mathieu Vinken Geert Bultynck Luc Leybaert 《Biochimica et Biophysica Acta (BBA)/Molecular Cell Research》2014
For decades, studies have been focusing on the neuronal abnormalities that accompany neurodegenerative disorders. Yet, glial cells are emerging as important players in numerous neurological diseases. Astrocytes, the main type of glia in the central nervous system , form extensive networks that physically and functionally connect neuronal synapses with cerebral blood vessels. Normal brain functioning strictly depends on highly specialized cellular cross-talk between these different partners to which Ca2 +, as a signaling ion, largely contributes. Altered intracellular Ca2 + levels are associated with neurodegenerative disorders and play a crucial role in the glial responses to injury. Intracellular Ca2 + increases in single astrocytes can be propagated toward neighboring cells as intercellular Ca2 + waves, thereby recruiting a larger group of cells. Intercellular Ca2+ wave propagation depends on two, parallel, connexin (Cx) channel-based mechanisms: i) the diffusion of inositol 1,4,5-trisphosphate through gap junction channels that directly connect the cytoplasm of neighboring cells, and ii) the release of paracrine messengers such as glutamate and ATP through hemichannels (‘half of a gap junction channel’). This review gives an overview of the current knowledge on Cx-mediated Ca2 + communication among astrocytes as well as between astrocytes and other brain cell types in physiology and pathology, with a focus on the processes of neurodegeneration and reactive gliosis. Research on Cx-mediated astroglial Ca2 + communication may ultimately shed light on the development of targeted therapies for neurodegenerative disorders in which astrocytes participate. This article is part of a Special Issue entitled: Calcium signaling in health and disease. Guest Editors: Geert Bultynck, Jacques Haiech, Claus W. Heizmann, Joachim Krebs, and Marc Moreau. 相似文献
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Bj?rn K. Klatt Andrea Holzschuh Catrin Westphal Yann Clough Inga Smit Elke Pawelzik Teja Tscharntke 《Proceedings. Biological sciences / The Royal Society》2014,281(1775)
Pollination improves the yield of most crop species and contributes to one-third of global crop production, but comprehensive benefits including crop quality are still unknown. Hence, pollination is underestimated by international policies, which is particularly alarming in times of agricultural intensification and diminishing pollination services. In this study, exclusion experiments with strawberries showed bee pollination to improve fruit quality, quantity and market value compared with wind and self-pollination. Bee-pollinated fruits were heavier, had less malformations and reached higher commercial grades. They had increased redness and reduced sugar–acid–ratios and were firmer, thus improving the commercially important shelf life. Longer shelf life reduced fruit loss by at least 11%. This is accounting for 0.32 billion US$ of the 1.44 billion US$ provided by bee pollination to the total value of 2.90 billion US$ made with strawberry selling in the European Union 2009. The fruit quality and yield effects are driven by the pollination-mediated production of hormonal growth regulators, which occur in several pollination-dependent crops. Thus, our comprehensive findings should be transferable to a wide range of crops and demonstrate bee pollination to be a hitherto underestimated but vital and economically important determinant of fruit quality. 相似文献
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Noah C. Benson Omar H. Butt David H. Brainard Geoffrey K. Aguirre 《PLoS computational biology》2014,10(3)
Several domains of neuroscience offer map-like models that link location on the cortical surface to properties of sensory representation. Within cortical visual areas V1, V2, and V3, algebraic transformations can relate position in the visual field to the retinotopic representation on the flattened cortical sheet. A limit to the practical application of this structure-function model is that the cortex, while topologically a two-dimensional surface, is curved. Flattening of the curved surface to a plane unavoidably introduces local geometric distortions that are not accounted for in idealized models. Here, we show that this limitation is overcome by correcting the geometric distortion induced by cortical flattening. We use a mass-spring-damper simulation to create a registration between functional MRI retinotopic mapping data of visual areas V1, V2, and V3 and an algebraic model of retinotopy. This registration is then applied to the flattened cortical surface anatomy to create an anatomical template that is linked to the algebraic retinotopic model. This registered cortical template can be used to accurately predict the location and retinotopic organization of these early visual areas from cortical anatomy alone. Moreover, we show that prediction accuracy remains when extrapolating beyond the range of data used to inform the model, indicating that the registration reflects the retinotopic organization of visual cortex. We provide code for the mass-spring-damper technique, which has general utility for the registration of cortical structure and function beyond the visual cortex. 相似文献