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731.
732.
Fabrizio Caldara Luca Bargelloni Lucilla Ostellari Eliana Penzo Lorenzo Colombo Tomaso Patarnello 《Molecular phylogenetics and evolution》1996,6(3):416-424
The phylogeny of the grey mullets is considered problematic both at the intra- and interfamily level. Such a difficulty arises from the highly homogeneous morphology displayed by this group of fish and, consequently, from the paucity of the key morphological characters suitable to address their phylogeny and evolution. In the present work, we have approached the phylogenetic and evolutionary relationships of seven species of Mugilidae, six of which from the Mediterranean Sea, on the basis of the DNA sequences of two mitochondrial genes (cytochromeband 12S rRNA). Despite the morphological homogeneity exhibited by the taxa considered, the two species of the genusMugil(M. cephalusandM. curema) showed a remarkable genetic divergence compared to all the other members of the family. The relative rate test revealed a significantly higher rate of evolution along theMugillineage. 相似文献
733.
734.
Kathryn Rozen-Gagnon Meigang Gu Joseph M. Luna Ji-Dung Luo Soon Yi Sasha Novack Eliana Jacobson Wei Wang Matthew R. Paul Troels K.H. Scheel Thomas Carroll Charles M. Rice 《Cell host & microbe》2021,29(5):834-848.e13
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735.
Wanessa Santana Simone S. C. de Oliveira Mariana H. Ramos André L. S. Santos Silvio S. Dolabella Eliana B. Souto Patrícia Severino Sona Jain 《化学与生物多样性》2021,18(9):e2100336
Leishmaniasis is a group of tropical diseases caused by parasitic protozoa belonging to the genus Leishmania. The disease is categorized in cutaneous leishmaniasis (CL), mucocutaneous leishmaniasis (MCL), and visceral leishmaniasis (VL). The conventional treatment is complex and can present high toxicity and therapeutic failures. Thus, there is a continuing need to develop new treatments. In this review, we focus on the novel molecules described in the literature with potential leishmanicidal activity, categorizing them in pre-clinical (in vitro, in vivo), drug repurposing and clinical research. 相似文献
736.
Santiago O. Bouzas Melisa S. Marini Eliana Torres Zelada Ailín L. Buzzi David A. Morales Vicente Pablo H. Strobl-Mazzulla 《Molecular biology of the cell》2016,27(12):1921-1927
One of the earliest manifestations of neural induction is onset of expression of the neural marker Sox2, mediated by the activation of the enhancers N1 and N2. By using loss and gain of function, we find that Sox2 expression requires the activity of JmjD2A and the Msk1 kinase, which can respectively demethylate the repressive H3K9me3 mark and phosphorylate the activating H3S10 (H3S10ph) mark. Bimolecular fluorescence complementation reveals that the adaptor protein 14-3-3, known to bind to H3S10ph, interacts with JMJD2A and may be involved in its recruitment to regulatory regions of the Sox2 gene. Chromatin immunoprecipitation reveals dynamic binding of JMJD2A to the Sox2 promoter and N-1 enhancer at the time of neural plate induction. Finally, we show a clear temporal antagonism on the occupancy of H3K9me3 and H3S10ph modifications at the promoter of the Sox2 locus before and after the neural plate induction. Taken together, our results propose a series of epigenetic events necessary for the early activation of the Sox2 gene in neural progenitor cells. 相似文献
737.
Alderrosy F. Rodrigues Cornélio S. Santiago Eliana Morielle-Versute Sebastião R. Taboga Mateus R. Beguelini 《Journal of morphology》2019,280(8):1141-1155
Artibeus lituratus is one of the most recognized bat species in the neotropics, probably due to its high abundance in urban areas. Despite its wide distribution, the morphology and physiology of its reproductive organs remain unclear. Thus, the aim of the present study was to describe the morphology and histology of the female reproductive organs of this species, and evaluate morphological variations during its different reproductive phases (nonreproductive, pregnant, lactating, etc.). Thirty adult females were collected, divided into six (6) sample groups, according to the reproductive status, and submitted to anatomical and histological analyses. We show that the ovaries of A. lituratus are polarized, present a low number of interstitial glands, have large and well-developed Graafian follicles and a persistent corpus luteum, and may present a functional everted corpus luteum. Ovulation is simple, unilateral and nonpreferential, possibly alternated in successive ovulations, and may be sequential, with the occurrence of postpartum estrus. The uterus is simplex, the implantation is fundic and interstitial and the placenta is chorioallantoic, discoidal, and hemochorial. The female reproductive organs of A. lituratus share similarities with the pattern observed in human, which indicates that A. lituratus may be an interesting animal model in reproductive studies. 相似文献
738.
Morphological analysis of the male reproductive accessory glands of the bat Artibeus lituratus (Phyllostomidae: Chiroptera)
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Renata T. S. Santos Laís R. M. Pires Edna S. S. Albernaz Cleber S. Andrade Cornélio S. Santiago Eliana Morielle‐Versute Sebastião R. Taboga Mateus R. Beguelini 《Journal of morphology》2018,279(2):228-241
Bats are distributed worldwide from tropical to temperate regions. Despite their wide geographical radiation and advances in studies using evolutionary approaches, aspects related to the reproduction of these animals remain poorly explored, especially those related to the male reproductive accessory glands (RAGs). Thus, the aim of this study was to analyze the morphophysiology of the male RAGs in the bat Artibeus lituratus. The RAGs in A. lituratus are composed of a compact intra‐abdominal glandular complex, consisting of the prostate with two prostatic regions (ventral and dorsal), plus Littre glands and a pair of extra‐abdominal bulbourethral glands. The ventral region of the prostate has an epithelium with variable morphology, due to its holocrine type of secretion. In contrast, the dorsal region has a typical cubic‐to‐columnar pseudostratified epithelium. Both regions contain two cell types, basal and secretory cells. Similar to the epithelial morphology, the secretion also varies, with the ventral region containing numerous PAS‐positive globular vesicles, whereas the dorsal region has a more fluid, hyaline and PAS‐negative secretion. Littre glands are dispersed in the connective tissue of the urethra, while the bulbourethral glands are located in the penile root, both glands with cubic‐to‐columnar pseudostratified epithelium and globular PAS‐positive secretion. The results demonstrate that the RAGs of A. lituratus are composed of two prostatic regions, ventral and dorsal, and urethral and bulbourethral glands, with no seminal vesicles. Each prostatic region has unique and distinctive characteristics, with the ventral region presenting an exclusive holocrine nature and the dorsal region having similarities to the ventral prostate of rodents. 相似文献
739.
Hematological parameters and the variations resulting from stress of Alouatta caraya during a wildlife rescue program in Brazil
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740.