排序方式: 共有195条查询结果,搜索用时 171 毫秒
111.
Margherita Bertuzzi Markus Schrettl Laura Alcazar-Fuoli Timothy C. Cairns Alberto Mu?oz Louise A. Walker Susanne Herbst Maryam Safari Angela M. Cheverton Dan Chen Hong Liu Shinobu Saijo Natalie D. Fedorova Darius Armstrong-James Carol A. Munro Nick D. Read Scott G. Filler Eduardo A. Espeso William C. Nierman Hubertus Haas Elaine M. Bignell 《PLoS pathogens》2014,10(10)
112.
Dodi Safari Nia Kurniati Lia Waslia Miftahuddin Majid Khoeri Tiara Putri Debby Bogaert Krzysztof Trzciński 《PloS one》2014,9(10)
Background
We studied the serotype distribution and antibiotic susceptibility of Streptococcus pneumoniae isolates carried by children infected with HIV in Jakarta, Indonesia.Methods
Nasopharyngeal swabs were collected from 90 HIV infected children aged 4 to 144 months. S. pneumoniae was identified by conventional and molecular methods. Serotyping was performed with sequential multiplex PCR and antibiotic susceptibility with the disk diffusion method.Results
We identified S. pneumoniae carriage in 41 children (46%). Serotype 19F was most common among 42 cultured strains (19%) followed by 19A and 6A/B (10% each), and 23F (7%). Most isolates were susceptible to chloramphenicol (86%), followed by clindamycin (79%), erythromycin (76%), tetracycline (43%), and sulphamethoxazole/trimethoprim (41%). Resistance to penicillin was most common with only 33% of strains being susceptible. Strains of serotypes targeted by the 13-valent pneumococcal conjugate polysaccharide vaccine (PCV13) were more likely to be multidrug resistant (13 of 25 or 52%) compared to non-PCV13 serotype isolates (3 of 17 or 18%; Fisher exact test p = 0.05).Conclusion
Our study provides insight into the epidemiology of pneumococcal carriage in young HIV patients in Indonesia. These findings may facilitate potential preventive strategies that target invasive pneumococcal disease in Indonesia. 相似文献113.
Elahe A. Mostaghel Andrew Morgan Xiaotun Zhang Brett T. Marck Jing Xia Rachel Hunter-Merrill Roman Gulati Stephen Plymate Robert L. Vessella Eva Corey Celestia S. Higano Alvin M. Matsumoto R. Bruce Montgomery Peter S. Nelson 《PloS one》2014,9(10)
Background
Factors influencing differential responses of prostate tumors to androgen receptor (AR) axis-directed therapeutics are poorly understood, and predictors of treatment efficacy are needed. We hypothesized that the efficacy of inhibiting DHT ligand synthesis would associate with intra-tumoral androgen ratios indicative of relative dependence on DHT-mediated growth.Methods
We characterized two androgen-sensitive prostate cancer xenograft models after androgen suppression by castration in combination with the SRD5A inhibitor, dutasteride, as well as a panel of castration resistant metastases obtained via rapid autopsy.Results
In LuCaP35 tumors (intra-tumoral T:DHT ratio 2∶1) dutasteride suppressed DHT to 0.02 ng/gm and prolonged survival vs. castration alone (337 vs.152 days, HR 2.8, p = 0.0015). In LuCaP96 tumors (T:DHT 10∶1), survival was not improved despite similar DHT reduction (0.02 ng/gm). LuCaP35 demonstrated higher expression of steroid biosynthetic enzymes maintaining DHT levels (5-fold higher SRD5A1, 41 fold higher, 99-fold higher RL-HSD, p<0.0001 for both), reconstitution of intra-tumoral DHT (to ∼30% of untreated tumors), and ∼2 fold increased expression of full length AR. In contrast, LuCaP96 demonstrated higher levels of steroid catabolizing enzymes (6.9-fold higher AKR1C2, 3000-fold higher UGT2B15, p = 0.002 and p<0.0001 respectively), persistent suppression of intra-tumoral DHT, and 6–8 fold induction of full length AR and the ligand independent V7 AR splice variant. Human metastases demonstrated bio-active androgen levels and AR full length and AR splice-variant expression consistent with the range observed in xenografts.Conclusions
Intrinsic differences in basal steroidogenesis, as well as variable expression of full length and splice-variant AR, associate with response and resistance to pre-receptor AR ligand suppression. Expression of steroidogenic enzymes and AR isoforms may serve as potential biomarkers of sensitivity to potent AR-axis inhibition and should be validated in additional models. 相似文献114.
Ying Gu Xin Chen Chaowei Shang Karnika Singh Mansoureh Barzegar Elahe Mahdavian Brian A. Salvatore Shanxiang Jiang Shile Huang 《PloS one》2014,9(11)
Fusarochromanone (FC101), a mycotoxin produced by the fungus Fusarium equiseti, is frequently observed in the contaminated grains and feedstuffs, which is toxic to animals and humans. However, the underlying molecular mechanism remains to be defined. In this study, we found that FC101 inhibited cell proliferation and induced cell death in COS7 and HEK293 cells in a concentration-dependent manner. Flow cytometric analysis showed that FC101 induced G1 cell cycle arrest and apoptosis in the cells. Concurrently, FC101 downregulated protein expression of cyclin D1, cyclin-dependent kinases (CDK4 and CDK6), and Cdc25A, and upregulated expression of the CDK inhibitors (p21Cip1 and p27Kip1), resulting in hypophosphorylation of Rb. FC101 also inhibited protein expression of Bcl-2, Bcl-xL, Mcl-1 and survivin, and induced expression of BAD, leading to activation of caspase 3 and cleavage of PARP, indicating caspase-dependent apoptosis. However, Z-VAD-FMK, a pan-caspase inhibitor, only partially prevented FC101-induced cell death, implying that FC101 may induce cell death through both caspase-dependent and -independent mechanisms. Our results support the notion that FC101 executes its toxicity at least by inhibiting cell proliferation and inducing cell death. 相似文献
115.
Plasmonics - Two-dimensional materials have emerged as new type of smart materials that may impact advanced photonic devices. Here, to increase the light absorption, a black phosphorus-based... 相似文献
116.
Samimi Mansooreh Dadkhah Adeleh Haddad Kashani Hamed Tajabadi-Ebrahimi Maryam Seyed Hosseini Elahe Asemi Zatollah 《Probiotics and antimicrobial proteins》2019,11(4):1355-1361
Probiotics and Antimicrobial Proteins - Data on the effects of synbiotic supplementation on glycemic control, lipid profiles, and atherogenic index of plasma (AIP) of women with polycystic ovary... 相似文献
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118.
Vahabzadeh Gelareh Soltani Hamidreza Barati Mahmood Golab Fereshteh Jafari-Sabet Majid Safari Sepideh Moazam Ashrafolsadat Mohamadrezaei Hananeh 《Molecular biology reports》2020,47(8):5711-5719
Molecular Biology Reports - Noscapine is an antitumor alkaloid derived from Papaver somniferum plants. Our previous study has demonstrated that exposure of noscapine on primary murine fetal... 相似文献
119.
Kermanshahi Sareh Ghanavati Ghazal Abbasi-Mesrabadi Mobina Gholami Mina Ulloa Luis Motaghinejad Majid Safari Sepideh 《Neurochemical research》2020,45(11):2573-2585
Neurochemical Research - Neurodegenerative disorders are characterized by mitochondrial dysfunction and subsequently oxidative stress, inflammation, and apoptosis that contribute to neuronal... 相似文献
120.
Khosrowabadi Elahe Karimi-Haghighi Saeideh Jamali Shole Haghparast Abbas 《Neurochemical research》2020,45(9):2230-2241
Neurochemical Research - A large amount of document has revealed that the orexin system in the reward circuity, including the nucleus accumbens (NAc), contributes to the modification of drug... 相似文献