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The differentiation of murine trophoblast giant cells (TGCs) is well characterised at the molecular level and, to some extent, the cellular level. Currently, there is a rudimentary understanding about factors regulating the cellular differentiation of secondary TGCs. Using day 8.5 p.c.-ectoplacental cone (EPC) explant in serum-free culture, we have found parathyroid hormone-related protein (PTHrP) to regulate cellular changes during TGC differentiation. PTHrP greatly stimulated the formation and organisation of actin stress fibres and actin expression in trophoblast outgrowth. This coincided with changing cell shape into a flattened/fibroblastic morphology, suppression of E-cadherin expression, and increased cell spreading in culture. PTHrP also increased the nuclear staining of beta-catenin and, similar to activator protein-2gamma (AP-2gamma), showed microtubule-dependent nuclear localisation in vitro. These cellular and behavioural changes correlated with changes in the expression of RhoGTPases and in both expression and phosphorylation of Eph/Ephrin kinases. The effects of PTHrP on trophoblast cellular differentiation were abolished after blocking its action. In conclusion, PTHrP provides an excellent example of the extrinsic factors that, through their network of activities, plays an important role in cellular differentiation of secondary TGCs. 相似文献
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Studies of the influence of fish aquaculture on benthic freshwater nematode assemblages are scarce, but could provide a way of gauging environmental effects. The abundance and diversity of nematode assemblages in response to Oreochromis niloticus aquaculture were investigated in Kafr El-Sheikh Governorate, Egypt, from July to November 2014 under conditions of irrigation (reference), fish farm pond with high Tilapia density, and fish farm pond effluent canal without fish. The nematode genera Adoncholaimus, Punctodora, Labronema, Oncholaimus and Odontolaimus were present at all sites. Environmental factors were not related to nematode distribution patterns. Tilapia predation and/or disturbance may explain reduced nematode abundance, especially of the largest genera, Adoncholaimus, Punctodora and Labronema at the fish farm site. The absence of fish from the drainage site allowed intergeneric nematode competitive exclusion, benefitting the largest nematodes and reducing diversity indices. 相似文献
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Randomized controlled study of a novel triple nitazoxanide (NTZ)‐containing therapeutic regimen versus the traditional regimen for eradication of Helicobacter pylori infection
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