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131.
Ahmed A. Aly Eid A. Zaky Hadeer A. Mahmoud Abdulmajeed F. Alrefaei Ahmed M. Hameed Hussain Alessa Abdulrahman A. Alsimaree Mohammed Aljohani Salah M. El-Bahy Sultan Kadasah 《Saudi Journal of Biological Sciences》2021,28(12):7142-7151
Oats are represented an important source for nutrition, and it have attracted a lot of attention in recent years. In this study we produced oatmeal cookies and oats was added to formula wheat by 50% and 75%. Also, we added cinnamon to treatments 3 and 4 by 5% to increase nutrition value of oatmeal cookies, improvement sensory evaluation and increase antioxidant properties. All the cookies treatments were storage at room temperature. The purposes of this study were to study antioxidant activity for oats and cinnamon. Also determined the chemical composition include (moisture content, protein, ash, total lipids, crude fibers, carbohydrates and total calories) for oats, white flour and oatmeal cookies treatments. In addition evaluated all of sensory evaluation contain (appearance, color, texture, taste and odor) and microbiological evaluation such as (total bacterial count, spore forming bacteria and mold and yeasts count) for oatmeal cookies treatments. Also, biological assays were preformed to measure level of GPT, GOT, urea, creatinine, total cholesterol, triglycerides, HDL, LDL, and glucose. Furthermore, histopathological examination of both liver and kidneys was analyzed. The obtained results were clarified that the antioxidant activity for oats and cinnamon were 52.91% and 87.91%. Moreover, addition of oats and cinnamon to the cookies improve sensory evaluation as made it more acceptable, decreasing microbial load principally treatments 4 (prepared by 75% oats + 5% cinnamon). Biochemical assays were improved in rats with cirrhosis of carbon tetrachloride and their histopathological examination of liver and kidneys. It was clear that the additions ground whole grain oats and cinnamon to wheat flour based cookies improve its nutritional, chemical, and biological functions properties. 相似文献
132.
Laith J. Abu-Raddad Hiam Chemaitelly Houssein H. Ayoub Peter Coyle Joel A. Malek Ayeda A. Ahmed Yasmin A. Mohamoud Shameem Younuskunju Patrick Tang Zaina Al Kanaani Einas Al Kuwari Adeel A. Butt Andrew Jeremijenko Anvar Hassan Kaleeckal Ali Nizar Latif Riyazuddin Mohammad Shaik Hanan F. Abdul Rahim Gheyath K. Nasrallah Hadi M. Yassine Mohamed Ghaith Al Kuwari Hamad Eid Al Romaihi Mohamed H. Al-Thani Abdullatif Al Khal Roberto Bertollini 《PLoS medicine》2021,18(12)
BackgroundThe epidemiology of the SARS-CoV-2 B.1.1.7 (or Alpha) variant is insufficiently understood. This study’s objective was to describe the introduction and expansion of this variant in Qatar and to estimate the efficacy of natural infection against reinfection with this variant.Methods and findingsReinfections with the B.1.1.7 variant and variants of unknown status were investigated in a national cohort of 158,608 individuals with prior PCR-confirmed infections and a national cohort of 42,848 antibody-positive individuals. Infections with B.1.1.7 and variants of unknown status were also investigated in a national comparator cohort of 132,701 antibody-negative individuals. B.1.1.7 was first identified in Qatar on 25 December 2020. Sudden, large B.1.1.7 epidemic expansion was observed starting on 18 January 2021, triggering the onset of epidemic’s second wave, 7 months after the first wave. B.1.1.7 was about 60% more infectious than the original (wild-type) circulating variants. Among persons with a prior PCR-confirmed infection, the efficacy of natural infection against reinfection was estimated to be 97.5% (95% CI: 95.7% to 98.6%) for B.1.1.7 and 92.2% (95% CI: 90.6% to 93.5%) for variants of unknown status. Among antibody-positive persons, the efficacy of natural infection against reinfection was estimated to be 97.0% (95% CI: 92.5% to 98.7%) for B.1.1.7 and 94.2% (95% CI: 91.8% to 96.0%) for variants of unknown status. A main limitation of this study is assessment of reinfections based on documented PCR-confirmed reinfections, but other reinfections could have occurred and gone undocumented.ConclusionsIn this study, we observed that introduction of B.1.1.7 into a naïve population can create a major epidemic wave, but natural immunity in those previously infected was strongly associated with limited incidence of reinfection by B.1.1.7 or other variants.Laith Abu-Raddad and colleagues describe the introduction and expansion of the SARS-CoV-2 B.1.1.7 variant in a national cohort in Qatar. 相似文献
133.
Samar A. Alghamdi Maryam H. Mugri Nahid M. H. Elamin Mona Awad Kamil Hind Osman Basma G. Eid Rasheed A. Shaik Soad S. Shaker Aziza Alrafiah 《Current issues in molecular biology》2022,44(6):2505
Dry mouth is characterized by lower saliva production and changes in saliva composition. In patients with some salivary gland function remaining, pharmaceutical treatments are not recommended; therefore, new, more effective methods of promoting saliva production are needed. Hence, this study aimed to provide an overview of the histological changes in the salivary gland in the model of isoproterenol (ISO)-induced degenerative changes in male Wistar rats and to evaluate the protective effect of piceatannol. Thirty-two male Wistar rats were randomly divided into four groups: the control group, the ISO group, and the piceatannol (PIC)-1, and -2 groups. After the third day of the experiment, Iso (0.8 mg/100 g) was injected intraperitoneally (IP) twice daily into the animals. PIC was given IP in different daily doses (20 and 40 mg/kg) for three days before ISO and seven days with ISO injection. The salivary glands were rapidly dissected and processed for histological, histochemical, immunohistochemical (Ki-67), and morphometric analysis. Upon seven days of treatment with ISO, marked hypertrophy was observed, along with an increased number of positive Ki-67 cells. Proliferation was increased in some endothelial cells as well as in ducts themselves. Despite the significant decrease in proliferation activity, the control group did not return to the usual activity level after treatment with low-dose PIC. Treatment with a high dose of PIC reduced proliferative activity to the point where it was substantially identical to the results seen in the control group. An ISO-driven xerostomia model showed a novel protective effect of piceatannol. A new era of regenerative medicine is dawning around PIC’s promising role. 相似文献
134.
Ipomoea carnea Jacq., a native shrub of South America, grows in dense populations along river beds, river banks, canals and other waterlogged
(wetland) areas. It has become naturalised along canals, drains, road sides and field edges in the Nile Delta, Egypt. The
rapid growth rate, spread and adaptability from xeric to aquatic habitats indicates that this plant may potentially become
a disastrous invasive species in Egyptian water bodies. Fifty established stands covering seven habitats (railway sides, waste
lands, road sides, drain and canal banks, road dividers and field edges) in the Nile Delta were used in this experiment. In
each stand, 20 ramets were permanently marked to estimate the monthly variations in such growth variables as phenology, height
and diameter of the ramet canopy, number of flowers, leaves and fruits. The results showed a significant variation in growth
variables relative to habitat types. Generally, I. carnea populations along the railway sides and field edges had the lowest values for most variables; while those of the road dividers,
road sides and canal banks produced the highest values. The growth of I. carnea follows a seasonal pattern where the highest values for most growth variables were obtained during September and October
and the lowest were recorded during June and July. The greatest flower and fruit production was observed between September
and December. Similarly, it was shown that the flowering time varied in relation to habitat types; it began earlier on road
sides and canal banks, but later on railway sides, road dividers and waste lands. Leaf areas of I. carnea populations in the wet habitats (e.g. drain and canal banks) were higher than those in other habitats. These results are
discussed in relation to other related studies. 相似文献
135.
Mohamed L. Ashour Mahmoud Z. El-Readi Ahmed Tahrani Safaa Y. Eid Michael Wink 《Phytochemistry letters》2012,5(2):387-392
A detailed phytochemical study of the aerial parts of Bupleurum marginatum Wall. ex DC revealed a novel aryltetraline lactone lignan identified as 9-(benzo[d][1,3]dioxol-5-yl)-6,7,8-trimethoxy-3a,4,9,9a-tetrahydronaphtho[2,3-c]furan-1(3H)-one (marginatoxin) along with nine known compounds and characterization of five other compounds either by GLC/MS or LC/MS techniques. Chemical structures of the isolated compounds were unambiguously elucidated by both 1D, 2D NMR and mass spectrometry techniques.The in vitro cytotoxic activity of both methanol and dichloromethane extracts as well as the isolated compounds was assessed in two human cancer cell lines HepG2 and HeLa using the MTT assay. The new aryltetraline lactone lignan exhibited a potent cytotoxic activity with IC50 values of 12.14 and 16.90 μM after 24 h treatment for HepG2 and HeLa cells, respectively. 相似文献
136.
137.
Isolated interferon alpha-receptor complexes stabilized in vitro 总被引:3,自引:0,他引:3
We describe the extraction and stabilization in vitro of discrete complexes of interferon and cellular receptor proteins. A homogeneous complex of Mr 230 000 was extracted at the time of peak receptor binding (30 min). Complex formation was specific for human interferon. At later times a second complex could also be extracted suggesting transfer of interferon to a second site. 相似文献
138.
Jiang J Hoang M Young JR Chaung D Eid R Turner C Lin P Tong X Wang J Tan C Feighner S Palyha O Hreniuk DL Pan J Sailer AW MacNeil DJ Howard A Shearman L Stribling S Camacho R Strack A Van der Ploeg LH Goulet MT DeVita RJ 《Bioorganic & medicinal chemistry letters》2006,16(20):5270-5274
A series of 2-aminoquinoline compounds was prepared and evaluated in MCH1R binding and functional antagonist assays. Small dialkyl, methylalkyl, methylcycloalkyl, and cyclic amines were tolerated at the quinoline 2-position. The in vivo efficacy of compound 12 was explored and compared to that of a related inactive analog to determine their effects on food intake and body weight in rodents. 相似文献
139.
Chittezhath M Frump AL Jourquin J Lobdell N Eid JE 《Experimental cell research》2008,314(19):3551-3562
The SYT proto-oncoprotein (also known as SS18) is a gene expression regulator conserved across species. Although its biological function is still unknown, the importance of SYT as a housekeeping protein is illustrated by the lethal phenotype of SYT-null embryos. Notably, SYT is a component of the synovial sarcoma-associated translocation product, the SYT-SSX oncogene. SYT was previously reported as a mediator of cell adhesion. In the present study we show that SYT possesses distinct domains that control MDCK cyst formation in three-dimensional collagen cultures. While the carboxy-half of SYT, the QPGY domain, is required for cyst growth, the amino-terminal region appears to exert on this process a regulatory effect. Further analysis suggested that the purinergic G protein-coupled P2Y receptor signaling is involved in SYT-induced cystogenesis. Activation of this cascade is due to facilitation of ATP release in the extracellular space of polarized MDCK cells by SYT. These studies allow us to begin to understand the vital role of SYT in controlling epithelial morphogenesis and might explain the lethality of its loss in the developing embryo. 相似文献
140.