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Mirzajani Alireza Naderi Saeid Ganeh Ahmad Hadipour Ehsan Salahi Morteza Javidpour Jamileh 《Aquatic Ecology》2021,55(2):401-415
Aquatic Ecology - Information on the feeding habits of species is essential to develop appropriate conservation actions. This study aimed to assess spatial and temporal variation in the diet of the... 相似文献
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Habibi E Masoudi-Nejad A Abdolmaleky HM Haggarty SJ 《Functional & integrative genomics》2011,11(4):523-537
Epigenetic mechanisms have emerged as important components of a variety of human diseases, including cancer and central nervous
system disorders. Despite recent studies highlighting the role of epigenetic mechanisms in several neurodegenerative and neuropsychiatric
disorders, to date, there has been a paucity of studies exploring the role of epigenetic factors in Parkinson’s disease (PD).
PD is a progressive neurological disorder with characteristic motor and non-motor symptoms, including a range of neuropsychiatric
features, for which neither preventative nor effective long-term treatment strategies are available. It is one of the most
common neurodegenerative disorders and the second most prevalent after Alzheimer’s disease. In this review, we present several
lines of evidence suggesting that epigenetic factors may play an important role in the pathogenesis of PD and propose on this
basis a framework to guide future investigations into epigenetic mechanisms and systems biology of PD. These notions, together
with technical advances in the ability to perform genome-wide analysis of epigenomic states, and newly available small-molecule
probes targeting chromatin-modifying enzymes, may help design new treatment strategies for PD and other human diseases involving
epigenetic dysregulation. 相似文献
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Claudia Linker Irene De Almeida Matthew Stower Ehsan Ghorani Roberto Mayor 《Developmental biology》2009,327(2):478-1044
In Xenopus, the animal cap is very sensitive to BMP antagonists, which result in neuralization. In chick, however, only cells at the border of the neural plate can be neuralized by BMP inhibition. Here we compare the two systems. BMP antagonists can induce neural plate border markers in both ventral Xenopus epidermis and non-neural chick epiblast. However, BMP antagonism can only neuralize ectodermal cells when the BMP-inhibited cells form a continuous trail connecting them to the neural plate or its border, suggesting that homeogenetic neuralizing factors can only travel between BMP-inhibited cells. Xenopus animal cap explants contain cells fated to contribute to the neural plate border and even to the anterior neural plate, explaining why they are so easily neuralized by BMP-inhibition. Furthermore, chick explants isolated from embryonic epiblast behave like Xenopus animal caps and express border markers. We propose that the animal cap assay in Xenopus and explant assays in the chick are unsuitable for studying instructive signals in neural induction. 相似文献
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Shafiee A Seyedjafari E Soleimani M Ahmadbeigi N Dinarvand P Ghaemi N 《Biotechnology letters》2011,33(6):1257-1264
To evaluate the potential of three stem cells for cell therapy and tissue engineering applications, the biological behavior and osteogenic capacity of the newly introduced cord-blood-derived, unrestricted somatic stem cells (USSC) were compared with those of mesenchymal stem cells isolated from bone marrow (BM-MSC) and adipose tissue (AT-MSC). There was no significant difference between the rates of proliferation of the three stem cells. During osteogenic differentiation, alkaline phosphatase (ALP) activity peaked on day 7 in USSC compared to BM-MSC which showed the maximum value of ALP activity on day 14. However, BM-MSC had the highest ALP activity and mineralization during osteogenic induction. In addition, AT-MSC showed the lowest capacity for mineralization during differentiation and had the lowest ALP activity on days 7 and 14. Although AT-MSC expressed higher levels of collagen type I, osteonectin and BMP-2 in undifferentiated state, but these genes were expressed higher in BM-MSC during differentiation. BM-MSC also expressed higher levels of ALP, osteocalcin and Runx2 during induction. Taking together, BM-MSC showed the highest capacity for osteogenic differentiation and hold promising potential for bone tissue engineering and cell therapy applications. 相似文献
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Matsui K Nazifi E Hirai Y Wada N Matsugo S Sakamoto T 《The Journal of General and Applied Microbiology》2012,58(2):137-144
Scytonemin is a 544-Da hydrophobic pigment that can absorb UV-A radiation. It is present in cyanobacterial sheaths and is thought to function as a UV protectant. In this study, scytonemin was purified from the terrestrial cyanobacterium Nostoc commune, and its radical-scavenging activity was characterized. The purified scytonemin quenched an organic radical in vitro and accounted for up to 10% of the total activity of an ethanol extract of N. commune. These results suggest that the extracellular UV-absorbing pigment scytonemin has multiple roles, functioning as a UV sunscreen and an antioxidant relevant to anhydrobiosis in N. commune. 相似文献