排序方式: 共有45条查询结果,搜索用时 15 毫秒
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Accessing genetic diversity for crop improvement 总被引:1,自引:0,他引:1
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Marielle C Gold Heather D Ehlinger Matthew S Cook Susan K Smyk-Pearson Paul T Wille Ross M Ungerleider Deborah A Lewinsohn David M Lewinsohn 《PLoS pathogens》2008,4(2)
The control of Mycobacterium tuberculosis (Mtb) infection is heavily dependent on the adaptive Th1 cellular immune response. Paradoxically, optimal priming of the Th1 response requires activation of priming dendritic cells with Th1 cytokine IFN-γ. At present, the innate cellular mechanisms required for the generation of an optimal Th1 T cell response remain poorly characterized. We hypothesized that innate Mtb-reactive T cells provide an early source of IFN-γ to fully activate Mtb-exposed dendritic cells. Here, we report the identification of a novel population of Mtb-reactive CD4− αβTCR+ innate thymocytes. These cells are present at high frequencies, respond to Mtb-infected cells by producing IFN-γ directly ex vivo, and display characteristics of effector memory T cells. This novel innate population of Mtb-reactive T cells will drive further investigation into the role of these cells in the containment of Mtb following infectious exposure. Furthermore, this is the first demonstration of a human innate pathogen-specific αβTCR+ T cell and is likely to inspire further investigation into innate T cells recognizing other important human pathogens. 相似文献
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Tanja Sigl Gregor Schlamberger Hermine Kienberger Steffi Wiedemann Heinrich HD Meyer Martin Kaske 《Acta veterinaria Scandinavica》2010,52(1):32
Background
Conjugated linoleic acid (CLA) is a collective term for isomers of octadecadienoic acid with conjugated double-bond system. Thus, it was the objective to investigate whether milk composition and metabolic key parameters are affected by adding CLA to the diet of dairy cows in the first four weeks of lactation. 相似文献45.
Better discrimination was possible between phenylthiocarbamide (PTC)
solutions and the pure solvent when the solvent was a tasteless low-
concentration NaCl solution to which the subject had adapted than when the
solvent was purified water. The reverse was true for 6-n- propylthiouracil
(PROP). The differences in discrimination for PROP and PTC in the different
solvents were caused by differences in the intensity and persistence of
aftertastes, rather than a more intense perception of the PTC and PROP
tastes per se. This has consequences for traditional approaches to
measuring taste sensitivity, as well as indicating that PTC and PROP are
not necessarily equivalent indicators of 'taster' versus 'non-taster'
status.
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