全文获取类型
收费全文 | 5431篇 |
免费 | 611篇 |
国内免费 | 2篇 |
出版年
2021年 | 55篇 |
2020年 | 44篇 |
2019年 | 56篇 |
2018年 | 74篇 |
2017年 | 50篇 |
2016年 | 79篇 |
2015年 | 150篇 |
2014年 | 171篇 |
2013年 | 223篇 |
2012年 | 280篇 |
2011年 | 276篇 |
2010年 | 181篇 |
2009年 | 161篇 |
2008年 | 225篇 |
2007年 | 214篇 |
2006年 | 196篇 |
2005年 | 213篇 |
2004年 | 192篇 |
2003年 | 192篇 |
2002年 | 212篇 |
2001年 | 193篇 |
2000年 | 176篇 |
1999年 | 151篇 |
1998年 | 78篇 |
1997年 | 62篇 |
1996年 | 59篇 |
1995年 | 46篇 |
1994年 | 56篇 |
1993年 | 50篇 |
1992年 | 111篇 |
1991年 | 107篇 |
1990年 | 84篇 |
1989年 | 110篇 |
1988年 | 91篇 |
1987年 | 95篇 |
1986年 | 74篇 |
1985年 | 91篇 |
1984年 | 59篇 |
1983年 | 66篇 |
1982年 | 53篇 |
1981年 | 48篇 |
1980年 | 54篇 |
1979年 | 68篇 |
1978年 | 49篇 |
1977年 | 70篇 |
1976年 | 50篇 |
1975年 | 49篇 |
1974年 | 42篇 |
1973年 | 42篇 |
1971年 | 39篇 |
排序方式: 共有6044条查询结果,搜索用时 15 毫秒
901.
902.
J G Edwards 《BMJ (Clinical research ed.)》1978,2(6147):1296-1297
903.
Harold C. Edwards 《BMJ (Clinical research ed.)》1934,1(3830):973-977
904.
905.
906.
F. Swinford Edwards 《BMJ (Clinical research ed.)》1888,2(1450):815-816
907.
Jaclyn S. Long Yuko Fujiwara Joanne Edwards Claire L. Tannahill Gabor Tigyi Susan Pyne Nigel J. Pyne 《The Journal of biological chemistry》2010,285(46):35957-35966
We demonstrate here that the bioactive lipid sphingosine 1-phosphate (S1P) uses sphingosine 1-phosphate receptor 4 (S1P4) and human epidermal growth factor receptor 2 (HER2) to stimulate the extracellular signal regulated protein kinase 1/2 (ERK-1/2) pathway in MDA-MB-453 cells. This was based on several lines of evidence. First, the S1P stimulation of ERK-1/2 was abolished by JTE013, which we show here is an S1P2/4 antagonist and reduced by siRNA knockdown of S1P4. Second, the S1P-stimulated activation of ERK-1/2 was almost completely abolished by a HER2 inhibitor (ErbB2 inhibitor II) and reduced by siRNA knockdown of HER2 expression. Third, phyto-S1P, which is an S1P4 agonist, stimulated ERK-1/2 activation in an S1P4- and HER2-dependent manner. Fourth, FTY720 phosphate, which is an agonist at S1P1,3,4,5 but not S1P2 stimulated activation of ERK-1/2. Fifth, S1P stimulated the tyrosine phosphorylation of HER2, which was reduced by JTE013. HER2 which is an orphan receptor tyrosine kinase is the preferred dimerization partner of the EGF receptor. However, EGF-stimulated activation of ERK-1/2 was not affected by siRNA knockdown of HER2 or by ErbB2 (epidermal growth factor receptor 2 (or HER2)) inhibitor II in MDA-MB-453 cells. Moreover, S1P-stimulated activation of ERK-1/2 does not require an EGF receptor. Thus, S1P and EGF function in a mutually exclusive manner. In conclusion, the magnitude of the signaling gain on the ERK-1/2 pathway produced in response to S1P can be increased by HER2 in MDA-MB-453 cells. The linkage of S1P with an oncogene suggests that S1P and specifically S1P4 may have an important role in breast cancer progression. 相似文献
908.
909.
910.
B A Edwards A R Peters 《Comparative biochemistry and physiology. A, Comparative physiology》1988,90(1):93-98
1. There were few changes in the water balance of gerbils drinking 0.25 and 0.50 M NaCl solutions for 5 days. 2. Imbibition of 0.75 and 1.0 M saline resulted in some dehydration of the body fluids and considerable depletion of the neural lobe vasopressin store. 3. Although large amounts of NaCl were excreted, the maximum urine osmolality was considerably less than that found following water deprivation. 4. The imbibition of 1.0 M saline caused similar changes in water balance to water deprivation showing that little, if any, water was gained from this solution. 相似文献