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461.
462.
Ahsen Cakir Kubra Bozali Mert Celikten Eray Metin Guler Ebru Sahan Bulent Durdu Bilge Sumbul Abdurrahim Kocyigit 《Journal of biochemical and molecular toxicology》2023,37(1):e23240
Since most infectious diseases can develop into sepsis, it is still a major medical problem. Some in-vivo studies showed promising properties of fluoxetine in the treatment of infections. This study aims the antimicrobial effect of fluoxetine on the inflammatory process used in the treatment of sepsis-modeled rats. Besides, to investigate the efficacy of fluoxetine on modifying the antibiotic effect of imipenem in the inflammatory response. An experimental sepsis model was divided into negative control, positive control, fluoxetine 5 mg/kg, imipenem 60 mg/kg, and combined (fluoxetine; imipenem). Procalcitonin (PCT), high-sensitivity C-reactive protein (hs-CRP), lactate, myeloperoxidase activity (MPO), the inflammation markers interleukin-1β (IL-1β), interleukin-6 (IL-6), tumor necrosis factor-alfa (TNF-α), and monocyte chemoattractant protein-1 (MCP-1) levels were measured by enzyme-linked immunosorbent assay method. Oxidative stress markers, total oxidant status (TOS), total antioxidant status (TAS), total thiol (TT), and native thiol (NT) were measured using photometric methods. Oxidative stress index (OSI) was calculated according to TAS and TOS levels. The statistical analysis was performed by Statistical Package for Social Sciences version 22.0. After treatment with fluoxetine, imipenem, and combined groups, IL-1β, IL-6, TNF-α, MPO activity, MCP-1, hs-CRP, PCT, lactate, and the oxidative stress markers OSI, and disulfide levels were decreased (p < 0.05). The TT, NT, and TAS levels significantly statistically increased (p < 0.05). This research demonstrates that fluoxetine has effects as anti-inflammatory and antioxidant, and the combined treatment with antibioticum imipenem indicates positive synergistic effects in the experimental sepsis model. 相似文献
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464.
Nuclear magnetic resonance T
1 and T
2 relaxivities (r
1 and r
2) exhibit efficiency of a material to alter the relaxation rates (1/T
1 and 1/T
2), and they are being used for diagnostic purposes. The determination of total relaxivities (r
1t and r
2t) of cystic fluid content and ameloblastoma may therefore be useful for discriminative purposes. In order to determine what
makes total relaxivities of hemorrhagic cysts, four sets of tubes containing pooled cyst were doped with increasing concentrations
of iron, copper, albumin, and γ-globulins. These sets were replaced in a phantom together with six individual cysts and one
ameloblastoma. The relaxation times were measured by magnetic resonance imaging operating at 1.5 T. The relaxivities of individual
ions and proteins were determined from the slope of the relation between relaxation rates and concentration, while total relaxivities
were determined by using the increases in relaxation rates and material content of cystic fluid (MC). Iron, copper, albumin,
and γ-globulins were found to be the sources of r
1t and r
2t. Each of r
1t, r
2t, r
1tMC, r
2tMC, and r
2t/r
1t are distinctive parameters for each cystic category and ameloblastoma. Except for MC, the parameters measured for ameloblastoma
are significantly smaller than those of cysts. The similarity of the present results to those used in clinical applications
suggests that each of r
1t, r
2t, r
1tMC, r
2tMC, and r
2t/r
1t has an ability to discriminate various fluids and masses. The present work also suggests that r
1tMC, r
2tMC, and r
2t/r
1t can be determined in vivo. 相似文献
465.
466.
Aylin K?seler Onur ?ztürk Ayfer Atalay Erol ?. Atalay 《Molecular biology reports》2012,39(12):10747-10750
One of our previous studies presented the allele frequencies of D1S80 VNTR locus in province Denizli including the high frequencies of allele 24 and 18. In Denizli province of Turkey, the most common abnormal variant is Hb D-Los Angeles with a frequency of 57.8?% of the total abnormal Hbs. The aim of this study is to identify the allele frequencies of D1S80 VNTR locus in Hb D-Los Angeles carriers in Denizli province of Turkey. We studied unrelated 36 Hb D-Los Angeles carriers residing in Denizli province of Turkey. The size range of the D1S80 VNTR locus PCR products was determined first by agarose gel electrophoresis and then by a capillary electrophoresis system. For all subjects, DNA sequencing was performed. Allele frequency, theta (k) value, and observed and expected heterozygosity were calculated using Arlequin Software version 3.11. The most common alleles were the 24 (32?%), 18 (18.1?%) and 29 (16.7?%) alleles, and frequencies of these alleles were 0.329, 0.186 and 0.171 respectively. Other observed alleles percentages were 33, 2?%. We did not observe alleles 6, 15, 27 and 35, but we observed alleles 20 and 33. Results were in Hardy–Weinberg linkage disequilibrium. Observed heterozygosity was 0.889, and expected heterozygosity was 0.847. Theta (k) value was 4.91 (95?% confidence interval limits). According to our results, we concluded that Hb D-Los Angeles carriers have different allele frequencies in D1S80 VNTR and also have their own D1S80 VNTR locus divergence. 相似文献
467.
468.
Michelle Grace Acoba Ebru S. Selen Alpergin Santosh Renuse Lucía Fernández-del-Río Ya-Wen Lu Oleh Khalimonchuk Catherine F. Clarke Akhilesh Pandey Michael J. Wolfgang Steven M. Claypool 《Cell reports》2021,34(11):108869
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469.
The essential oils from the aerial parts of catmint (Nepeta meyeri Benth.) were analyzed by hydrodistillation with GC–MS. Fourteen compounds were identified in the yellowish essential oil
of the plant, representing more than 99.07% of the oil, of which the major components were found to be 4aα,7α,7aβ-nepetalactone
(83.4%) and 4aα,7α,7aα-nepetalactone (8.83%). The oils were characterized by relatively high content of oxygenated monoterpenes,
and were tested on the germination and antioxidative systems in early seedlings of seven weed species (Amaranthus retroflexus L., Bromus danthoniae Trin., Bromus intermedius Guss., Chenopodium album L., Cynodon dactylon L., Lactuca serriola L., and Portulaca oleracea L.) and autotoxicity. The essential oil of N. meyeri inhibited seed germination by more than 50% in three weed species (B. danthoniae, B. intermedius, and L. serriola) when applied at a concentration of 0.01%. When the same oils were applied at 0.02% concentration, the inhibition of germination
was more than 70% in two weeds (C. album and C. dactylon) and was 100% in four weeds (A. retroflexus, B. danthoniae, B. intermedius, and L. serriola). The essential oils increased CAT activity in all the weed species and decreased SOD activity, except in A. retroflexus. POX activity did not exhibit a revealing situation in the weed species tested. The essential oils increased the level of
lipid peroxidation and hydrogen peroxide (H2O2) concentration in all the weeds studied. Our results show that the essential oils of N. meyeri have an important phytotoxic effect on seed germination and, consequently, seedling growth by exhausting antioxidative system
of the weeds. The phytotoxic activity of the essential oils may be attributed to their relatively high content of oxygenated
monoterpenes, especially 4aα,7α,7aβ-nepetalactone. It can be suggest that the essential oils of N. meyeri have the potential to be used as a bioherbicide. 相似文献
470.