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41.
42.
Heptacaine, a new local anasthetic, and some intermediary products of its synthesis were shown to have nonmutagenic effects
onS. typhimurium undE. coli. 相似文献
43.
Križková L. Belicová A. Dobias J. Krajčovič J. Ebringer L. 《World journal of microbiology & biotechnology》2002,18(9):867-873
The antibacterial activity of the probiotic bacterium Enterococcus faecium M-74 was assessed on De Man–Rogosa–Sharpe (MRS), Todd–Hewitt (T–H), M17 (M-17) and brain heart infusion (BHI) media with sodium selenite pentahydrate (+Se) and without sodium selenite pentahydrate (–Se) under aerobic or anaerobic conditions against nine bacterial pathogens. The highest antibacterial activity was found to be in the MRS medium under anaerobic conditions. There were no differences in the antibacterial activity between MRS(+Se) and MRS(–Se) media. The antimutagenic activity of MRS(+Se) and MRS(–Se) extracts after culture with E. faecium M-74 as well as of live and killed cells of E. faecium M-74 grown in the presence or absence of Se against the genotoxicity of ofloxacin (OFL) and acridine orange (AO) was determined in the Euglena gracilis assay. The MRS(+Se) extracts showed a significantly higher activity in reducing the genotoxicity of OFL and AO than MRS(–Se) extracts. The live cells of the probiotic strain M-74 exhibited higher antimutagenic activity than the killed bacterial cells, but differed depending on the mutagen used. However, the live bacterial cells grown in the presence of Se showed significantly higher antimutagenic activity. These results suggest a potential benefit for the future development of new Se-enriched probiotics exhibiting higher antimutagenic properties. 相似文献
44.
Hyperthermia (37 degrees C permanently) and heat shock (42 degrees C for 10 min, and then 27 degrees C) retarded the elimination of chloroplasts from the flagellate Euglena gracilis induced by quinolone antibacterial chemotherapeutics (OA, NA, Cnx, Ofx, Cpfx, Enx, Nfx) in comparison with their action at 27 degrees C. In the case of OA, NA, and Cnx those hyperthermic conditions completely blocked their action against chloroplasts. On the other hand, both temperature regimes accelerated the antichloroplast activity of the mutagens/carcinogens nitrosoguanidine and furylfuramide. 相似文献
45.
46.
6-Substituted derivatives of 2-benzthiazolthiol and allyl (2-benzthiazolylthio)acetate exhibit, after an exposure to light,
and inhibitory action on the division of dark-depigmentedEuglena cells, as well as the synthesis of chlorophyll. These substances also have a marked inhibitory effect on the development
of plastids in nondividing cells maintained under resting conditions. No induction of heterotrophic plastidfree mutants was
found under growth or resting conditions. 相似文献
47.
Milk is a complex physiological liquid that simultaneously provides nutrients and bioactive components that facilitate the
successful postnatal adaptation of the newborn infant by stimulating cellular growth and digestive maturation, the establishment
of symbiotic microflora, and the development of gut-associated lymphoid tissues. The number, the potency, and the importance
of bioactive compounds in milk and especially in fermented milk products are probably greater than previously thought. They
include certain vitamins, specific proteins, bioactive peptides, oligosaccharides, organic (including fatty) acids. Some of
them are normal milk components, others emerge during digestive or fermentation processes. Fermented dairy products and probiotic
bacteria decrease the absorption of cholesterol. Whey proteins, medium-chain fatty acids and in particular calcium and other
minerals may contribute to the beneficial effect of dairy food on body fat and body mass. There has been growing evidence
of the role that dairy proteins play in the regulation of satiety, food intake and obesity-related metabolic disorders. Milk
proteins, peptides, probiotic lactic acid bacteria, calcium and other minerals can significantly reduce blood pressure. Milk
fat contains a number of components having functional properties. Sphingolipids and their active metabolites may exert antimicrobial
effects either directly or upon digestion. 相似文献
48.
Naturally occurring plant phenolics,p-coumaric acid (PA), caffeic acid (CA), ferulic acid (FA) and gentisic acid (GA) (25–100 nmol/L) had protective effects on
acridine orange (AO; 216 μmol/L)- and ofloxacin (3 μmol/L)-induced genotoxicity inSalmonella typhimurium. FA, GA and CA exhibited a significant concentration-dependent protective effect against the genotoxicity of AO and ofloxacin,
with the exception of PA, which at all concentrations tested abolished the AO and ofloxacin genotoxicity. UV spectrophotometric
measurements showed the interaction of PA, FA, GA and CA with AO but not with ofloxacin; this interaction is obviously responsible
for the reduction of AO-inducedS. typhimurium mutagenicity. In the case of ofloxacin the antimutagenic effect of PA, FA, GA and CA is assumed to be a result of their ability
to scavenge reactive oxygen species (ROS) produced by ofloxacin. 相似文献
49.
L. Ebringer M. Ferenčík N. Lahitová L. Kačáni D. Michálková 《World journal of microbiology & biotechnology》1995,11(3):294-298
Statistically significant antigenotoxic activity was exerted by six of nine strains of lactic acid bacteria tested (Lactobacillus delbrueckii subsp. bulgaricus, Staphylococcus carnosus, Streptococcus thermophilus, L. rhamnosus, Enterococcus faecium and En. faecalis) against nitrovin and 2-aminofluorene in Salmonella typhimurium TA100 and TA97. The mutagenic activity of both mutagens was substantially decreased by viable bacteria; cells heated to 100°C for 15 min were ineffective. In vitro, En. faecium stimulated the basic metabolic activities of human neutrophils which were essential for their antimicrobial and cytotoxic activity, whereas stimulation of guinea-pig macrophages was not so effective. Similar immuno-stimulatory effects were observed with both viable and heat-inactivated bacteria.L. Ebringer, M. Lahitová and D. Michálková are with the Institute of Molecular and Subcellular Biology, Comenius University, Odborárske nám. 5, SK-81107 Bratislava, Slovakia. M. Fereník and L. Kaáni are with the Institute of Immunology, Faculty of Medicine, Comenius University, SK-81108 Bratislava, Slovakia. 相似文献
50.
In a study of the carriage of faecal Klebsiella pneumoniae in 106 patients with rheumatoid arthritis the incidence of carriage was higher in men (28%) than women (14%) (p < 0.001) and klebsiellae were isolated on two or more occasions from a higher proportion of men than women (p < 0.002). The incidence of carriage was increased among patients with rheumatoid arthritis who had B7 cross-reacting (B7 CREG) antigens (32% v 13%--p < 0.001). Carriage of klebsiellae was not associated with clinical disease activity, raised erythrocyte sedimentation rate, drug treatment, or the presence of HLA Dw4 or DRw4 or both. Thus the carriage and prevalence of faecal Klebsiella pneumoniae appear to be partly determined by the sex and HLA state of the host. 相似文献