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排序方式: 共有323条查询结果,搜索用时 15 毫秒
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David C. Pryde Martin Corless David R. Fenwick Helen J. Mason Blanda C. Stammen Peter T. Stephenson David Ellis David Bachelor David Gordon Christopher G. Barber Anthony Wood Donald S. Middleton David C. Blakemore Gemma C. Parsons Rachel Eastwood Michelle Y. Platts Keith Statham Kerry A. Paradowski Catherine Burt Wolfgang Klute 《Bioorganic & medicinal chemistry letters》2009,19(4):1084-1088
The synthesis of a range of novel amine-containing structures and their primary potency as inhibitors of HIV-1 fusion via blocking of the CCR5 receptor is described. The development of the medicinal chemistry strategy and SAR’s which led to the identification of the piperidine amide compounds 33 and 36 as excellent leads for further evaluation is described, along with key physicochemical data which highlighted their lead potential. 相似文献
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Lithiation‐Induced Dilation Mapping in a Lithium‐Ion Battery Electrode by 3D X‐Ray Microscopy and Digital Volume Correlation 下载免费PDF全文
David S. Eastwood Vladimir Yufit Jeff Gelb Allen Gu Robert S. Bradley Stephen J. Harris Daniel J. L. Brett Nigel P. Brandon Peter D. Lee Philip J. Withers Paul R. Shearing 《Liver Transplantation》2014,4(4)
Recent advances in high‐resolution 3D X‐ray computed tomography (CT) allow detailed, non‐destructive 3D structural mapping of a complete lithium‐ion battery. By repeated 3D image acquisition (time lapse CT imaging) these investigations of material microstructure are extended into the fourth dimension (time) to study structural changes of the device in operando. By digital volume correlation (DVC) of successive 3D images the dimensional changes taking place during charge cycling are quantified at the electrode level and at the Mn2O4 particle scale. After battery discharging, the extent of lithiation of the manganese (III/IV) oxide grains in the electrode is found to be a function of the distance from the battery terminal with grains closest to the electrode/current collector interface having the greatest expansion (≈30%) and grains furthest from the current collector and closest to the counter electrode showing negligible dilation. This implies that the discharge is limited by electrical conductivity. This new CT+DVC technique is widely applicable to the 3D exploration of the microstructural degradation processes for a range of energy materials including fuel cells, capacitors, catalysts, and ceramics. 相似文献
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Laura Bozal-Basterra Itziar Martín-Ruíz Lucia Pirone Yinwen Liang Jón Otti Sigurðsson Maria Gonzalez-Santamarta Immacolata Giordano Estibaliz Gabicagogeascoa Angela de Luca Jose A. Rodríguez Andrew O.M. Wilkie Jürgen Kohlhase Deborah Eastwood Christopher Yale Jesper V. Olsen Michael Rauchman Kathryn V. Anderson James D. Sutherland Rosa Barrio 《American journal of human genetics》2018,102(2):249-265
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L J Kinlen J B Eastwood D N Kerr J F Moorhead D O Oliver B H Robinson H E de Wardener A J Wing 《BMJ (Clinical research ed.)》1980,280(6229):1401-1403
The incidence of cancer and related mortality was studied in 1651 patients from six dialysis centres in England over 10 years. The only type of cancer for which there was a significant excess was non-Hodgkin''s lymphoma (four cases observed against an expected incidence of 0.15 (p < 0.001); three deaths against an expected 0.1 (p < 0.001)). This excess could not be attributed to either subsequent transplantation or treatment with immunosuppressive drugs. Since immunodepression is a feature of chronic renal failure, these observations together with those on patints treated with immunosuppressive drugs suggest that immunosuppression favours the development of non-Hodgkin''s lymphoma. Studies in which it is concluded that patients receiving dialysis show an excess of other types of cancer have certain shortcomings; the unusual opportunities for detecting cancer in such patients may account for some of the reported excess. 相似文献