全文获取类型
收费全文 | 228篇 |
免费 | 13篇 |
出版年
2013年 | 6篇 |
2012年 | 3篇 |
2011年 | 6篇 |
2010年 | 6篇 |
2009年 | 7篇 |
2008年 | 8篇 |
2007年 | 5篇 |
2006年 | 4篇 |
2005年 | 8篇 |
2004年 | 2篇 |
2003年 | 2篇 |
2002年 | 2篇 |
2001年 | 2篇 |
2000年 | 4篇 |
1999年 | 2篇 |
1998年 | 6篇 |
1997年 | 3篇 |
1996年 | 4篇 |
1995年 | 2篇 |
1994年 | 4篇 |
1993年 | 2篇 |
1991年 | 3篇 |
1990年 | 2篇 |
1989年 | 2篇 |
1988年 | 2篇 |
1987年 | 6篇 |
1986年 | 4篇 |
1984年 | 2篇 |
1983年 | 5篇 |
1982年 | 2篇 |
1981年 | 3篇 |
1979年 | 2篇 |
1977年 | 2篇 |
1975年 | 4篇 |
1972年 | 3篇 |
1971年 | 4篇 |
1970年 | 2篇 |
1968年 | 3篇 |
1959年 | 4篇 |
1958年 | 15篇 |
1957年 | 9篇 |
1956年 | 5篇 |
1955年 | 3篇 |
1954年 | 9篇 |
1953年 | 7篇 |
1952年 | 10篇 |
1951年 | 9篇 |
1950年 | 8篇 |
1949年 | 7篇 |
1948年 | 3篇 |
排序方式: 共有241条查询结果,搜索用时 62 毫秒
11.
Characterization of terminal NeuNAcalpha2-3Galbeta1-4GlcNAc sequence in lipooligosaccharides of Neisseria meningitidis 总被引:1,自引:0,他引:1
Group B and C Neisseria meningitidis are the major cause of meningococcal
disease in the United States and in Europe. N . meningitidis
lipooligosaccharide (LOS), a major surface antigen, can be divided into 12
immunotypes of which L1 through L8 were found among Group B and C
organisms. Groups B and C but not Group A may sialylate their LOSs with
N-acetylneuraminic acid (NeuNAc) at the nonreducing end because they
synthesize CMP-NeuNAc. Using sialic acid-galactose binding lectins as
probes in an ELISA format, six of the eight LOS immunotypes (L2, L3, L4,
L5, L7, and L8) in Groups B and C bound specifically to Maackia amurensis
leukoagglutinin (MAL), which recognizes NeuNAcalpha2- 3Galbeta1-4GlcNAc/Glc
sequence, but not to Sambucus nigra agglutinin, which binds
NeuNAcalpha2-6Gal sequence. The combination of SDS-PAGE and MAL-blot
analyses revealed that these six LOSs contained only the
NeuNAcalpha2-3Galbeta1-4GlcNAc trisaccharide sequence in their 4.1 kDa LOS
components, which have a common terminal lacto-N-neotetraose (LNnT,
Galbeta1-4GlcNAcbeta1-3Galbeta1-4Glc) structure when nonsialylated as shown
by previous studies. The LOS-lectin binding was abolished when the LOSs
were treated with Newcastle disease viral neuraminidase which cleaves
alpha2-->3 linked sialic acid. Methylation analysis of a representative
LOS (L2) confirmed that NeuNAc is 2-->3 linked to Gal. Thus, these LOSs
structurally mimic certain glycolipids, i.e., paragloboside (LNnT-ceramide)
and sialylparagloboside and some glycoproteins in having LNnT and
N-acetyllactosamine sequences, respectively, with or without alpha2-->3
linked NeuNAc. The molecular mimicry of the LOSs may play a role in the
pathogenesis of N.meningitidis by assisting the organism to evade host
immune defenses in man.
相似文献
12.
C. C. H. ELLIOTT 《Ibis》1990,132(2):232-237
Recent studies on the migrations of the Red-billed Quelea Quelea quelea have shown that while the species is capable of long-distance movements of hundreds of kilometres, the actual migrations probably more often consist of shorter distances with a flexible timing. This flexibility allows adjustments to be made to the rainfall distribution in a particular year. New information comes from studies on the breeding distribution, on the plumage and moult of local populations, and from attempts to apply new techniques such as mass-marking with fluorescent particles. Breeding has been shown to be both more widespread and more frequent than previously recognized, while local populations can prolong breeding in one place if rainfall continues. Local populations have been identified that are apparently distinct, with limited intermixing with other populations, and some data suggest that intermixing may be reduced by flock or group cohesion. The flexibility of the migrations means that predictions of major influxes of quelea into agricultural areas have proved difficult to make, especially in regions where the rainfall patterns are complex and variable, such as East Africa. 相似文献
13.
14.
15.
16.
17.
18.
gamma-Aminobutyric acid and factor I 总被引:1,自引:0,他引:1
19.
20.