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171.
172.
摘要目的:观察复方斑蝥胶囊联合放疗治疗鼻咽癌的临床效果及不良反应。方法:将2007年6月至2010年12月来我科就诊的120例Ⅱ、Ⅲ期低分化鳞状细胞鼻咽癌伴有颈淋巴结转移的患者随机分为复方斑蝥胶囊辅助放疗组、甘氨双唑钠辅助放疗组(阳性对照组)和单纯放疗组(阴性对照组),每组各40例,比较治疗后各组患者的治疗效果和不良反应。结果:各组患者在接受相同放射疗程的情况下,复方盥蝥胶囊辅助放疗组和甘氨双唑钠辅助放疗组的治疗总有效率均明显优于单纯放疗组(P〈0.05),但复方斑蝥胶囊辅助放疗组与甘氨双唑钠辅助放疗组比较无明显差异(P〉0.05)。复方斑蝥胶囊辅助放疗组皮肤反应的发生率明显低于单纯放疗组(P〈O.05);皮肤反应、黏膜反应、口腔溃疡和心电图异常的发生率均明显低于甘氨双唑钠辅助放疗组(P〈O.05),但两组恶心呕吐的发生率比较无明显差异(P〉0.05)。结论:复方斑蝥胶囊辅助治疗可显著提高放疗治疗鼻咽癌的临床疗效,且无明显毒副作用,值得临床推广应用。 相似文献
173.
Nadine Shehata Alan J. Forster Nadine Lawrence Robin Ducharme Dean A. Fergusson Micha?l Chassé Deanna M. Rothwell Paul C. Hébert Alan T. Tinmouth Kumanan Wilson 《PloS one》2015,10(9)
While it is known that the use of health care resources increases at the end of life in patients admitted to the Intensive Care Unit (ICU), the allocation of blood products at the end of life has not been described. The objective of this study was to describe overall transfusion patterns in the ICU, and specifically in patients who die in hospital. We conducted a retrospective cohort study of adult patients admitted to the ICU of a university-affiliated hospital, who were discharged or died between November 1, 2006 and June 30, 2012. During the study period, 10,642 patients were admitted at least once to the ICU. Of these patients, 4079 (38.3%) received red blood cells (RBCs), plasma or platelets in the ICU. The ICU mortality rate was 28.1% and in-hospital mortality rate was 32.3%. Among 39,591 blood product units transfused over the course of the study in the ICU (18,144 RBC units, 16,920 plasma units and 4527 platelet units), 46.2% were administered to patients who later died within the same hospitalization (41.2% of RBCs, 50.4% of plasma and 50.8% of platelets). Of all blood product units (RBCs, plasma and platelets) administered in the ICU over the study period, 11% were given within the last 24 hours before death. A large proportion of blood products used in the ICU are administered to patients who ultimately succumb to their illness in hospital, and many of these blood units are given in close proximity to death. 相似文献
174.
The effect of ABA on root growth, secondary-root formation androot gravitropism in seedlings of Zea mays was investigatedby using Fluridone-treated seedlings and a viviparous mutant,both of which lack carotenoids and ABA. Primary roots of seedlingsgrown in the presence of Fluridone grew significantly slowerthan those of control (i.e. untreated) roots. Elongation ofFluridone-treated roots was inhibited significantly by the exogenousapplication of 1 mM ABA. Exogenous application of 1 µMand 1 nM ABA had either no effect or only a slight stimulatoryeffect on root elongation, depending on the method of application.The absence of ABA in Fluridone-treated plants was not an importantfactor in secondary-root formation in seedlings less than 910d old. However, ABA may suppress secondary-root formation inolder seedlings, since 11-d-old control seedlings had significantlyfewer secondary roots than Fluridone-treated seedlings. Rootsof Fluridone-treated and control seedlings were graviresponsive.Similar data were obtained for vp-9 mutants of Z. mays, whichare phenotypically identical to Fluridone-treated seedlings.These results indicate that ABA is necessary for neither secondary-rootformation nor for positive gravitropism by primary roots. Zea mays, gravitropism, carotenoid-deficient, Fluridone, root growth, vp-9 mutant 相似文献
175.
The effects of carbon dioxide concentrations up to 8 per centin air on uptake of potassium and chloride at two pH levels,nominally pH 6 and 8, werestudied. In all experiments, enhanced uptake of potassium occurred atthe higher pH level with carbon dioxidefree air, but chlorideuptake was generally unaffected. At nominal pH 6, 1 per cent carbon dioxide reduced and 6 percent increased potassium uptake. There was no effect on chlorideuptake except with 1 per cent carbon dioxide where a markedenhancement was recorded. At nominal pH 8, l and 2 per cent carbon dioxide increased potassiumuptake whereas 6 and 8 per cent were inhibitory. Chloride uptakewas favoured by 1 and 8 per cent concentrations of the gas. 相似文献
176.
177.
The toxicity of trimethyltin chloride and triethyltin sulphate on animal tissues was assessed by their effects on isolated phrenic nerve-diaphragm preparations. Studies by electron microscopy show that the inhibitory effects of these compounds on the muscular contractility of this tissue are associated with (a) the disruption of mitochondria and disorganisation of muscle fibres and (b) the depletion of neuromicrotubules in the axons of nerves innervating the muscle. The neurotoxie effect of triethyltin sulphate on neuromicrotubules is further substantiated by its inhibition (in a concentration-dependent manner) of the specific colchicine-binding activity of the crude and purified tubulin preparations derived from brain tissue. In addition, both triethyltin sulphate and trimethyltin chloride at a concentration greater than 100 μM completely prevent the normal in vitro assembly of microtubules from tubulin. 相似文献
178.
R. Matheoud A.L. Goertzen L. Vigna J. Ducharme G. Sacchetti M. Brambilla 《Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)》2012,28(3):210-220
PET scanners require routine monitoring and quality control (QC) to ensure proper scanner performance. QC helps to ensure that PET equipment performs as specified by the manufacturer and that there have not been significant changes in the system response since acceptance. In this work we describe the maintenance history and we report on the results obtained from the PET system QC testing program over 5 years at two centers, both utilizing a Siemens Biograph 16 HiRez PET/CT system. QC testing programs were based on international standards and included the manufacturer’s daily QC, monthly uniformity and sensitivity, quarterly cross-calibration and annual resolution and image quality.For the Winnipeg and Novara sites, two and one PET detector blocks have been replaced, respectively. Neither system has had other significant PET system related hardware replacements. The manufacturer’s suggested daily QC was sensitive to detecting problems in the function of PET detector elements. The same test was not sensitive for detecting long term drifts in the systems: the Novara system observed a significant deterioration over five years of testing in the sensitivity which exhibited a decrease of 16% as compared to its initial value measured at system installation. The measure of the energy spectrum, showed that the 511 keV photopeak had shifted to a position of 468 keV. This shift was corrected by having service personnel perform a complete system calibration and detector block setup.We recommend including tests of system energy response and of sensitivity as part of a QC program since they can provide useful information on the actual performance of the scanner. A modification of the daily QC test by the manufacturer is suggested to monitor the long term stability of the system. Image quality and spatial resolution tests have proven to be of limited value for monitoring the system over time. 相似文献
179.
C. H. NG S. C. KOH S. L. LEE K. K. S. NG A. MARK M. NORWATI R. WICKNESWARI 《Molecular ecology resources》2005,5(3):572-575
This study reports the isolation of 15 microsatellites in Acacia hybrid (Acacia mangium×Acacia auriculiformis) based on the 5′ anchored polymerase chain reaction technique. Polymorphism of these loci was evaluated in a sample of 24 hybrid individuals. The level of polymorphism ranged from two to eight alleles with an observed heterozygosity ranging from 0.083 to 0.875. These loci were also characterized in both the parental species. The number of alleles ranged from two to six for both A. mangium and A. auriculiformis with the observed heterozygosity values ranging from 0.167 to 0.625 and 0.042 to 0.458 respectively. Five of these loci demonstrated Mendelian inheritance in a segregating F1 population; four presented a distorted ratio and the remaining six did not segregate in progenies as they were homozygous in both parents. 相似文献
180.
Steven Hawken Jeffrey C. Kwong Shelley L. Deeks Natasha S. Crowcroft Robin Ducharme Douglas G. Manuel Kumanan Wilson 《PloS one》2013,8(12)