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991.
992.
Chun-Chi Liu Chin-Chung Lin Ker-Chau Li Wen-Shyen E Chen Jiun-Ching Chen Ming-Te Yang Pan-Chyr Yang Pei-Chun Chang Jeremy JW Chen 《BMC bioinformatics》2007,8(1):164
Background
Genome-wide identification of specific oligonucleotides (oligos) is a computationally-intensive task and is a requirement for designing microarray probes, primers, and siRNAs. An artificial neural network (ANN) is a machine learning technique that can effectively process complex and high noise data. Here, ANNs are applied to process the unique subsequence distribution for prediction of specific oligos. 相似文献993.
Gutiérrez-Rodríguez C Morris MR Dubois NS Queiroz Kd 《Molecular phylogenetics and evolution》2007,43(1):111-123
Swordtail fish have been studied extensively in relation to diverse aspects of biology; however, little attention has been paid to the patterns of genetic variation within and among populations of swordtails. In this study, we sequenced the mtDNA control region from 65 individuals and 10 populations of Xiphophorus cortezi to investigate the genetic variation within and among populations, including tests for correlations between genetic and geographic distances and tests for species monophyly. We found low gene and nucleotide diversity within populations and high degrees of genetic differentiation among populations. Significant and positive correlations between genetic distance and both river and straight-line geographic distance indicate that genetic differentiation among X. cortezi populations can be explained, to some extent, by an isolation-by-distance model and provide evidence of stream capture. Phylogenetic analyses suggest that X. cortezi is paraphyletic relative to X. malinche, raising questions concerning the status of these taxa as separate species. 相似文献
994.
Sandham DA Aldcroft C Baettig U Barker L Beer D Bhalay G Brown Z Dubois G Budd D Bidlake L Campbell E Cox B Everatt B Harrison D Leblanc CJ Manini J Profit R Stringer R Thompson KS Turner KL Tweed MF Walker C Watson SJ Whitebread S Willis J Williams G Wilson C 《Bioorganic & medicinal chemistry letters》2007,17(15):4347-4350
High throughput screening identified a phenoxyacetic acid scaffold as a novel CRTh2 receptor antagonist chemotype, which could be optimised to furnish a compound with functional potency for inhibition of human eosinophil shape change and oral bioavailability in the rat. 相似文献
995.
996.
Philippe Bauer Françoise Belleville-Nabet Florence Watelet Françoise Dubois Alain Larcan 《Biological trace element research》1995,47(1-3):157-163
Circulatory shock and its treatment have been compared to a whole-body ischemia and reperfusion with activation of oxygen-derived free radicals. A pilot study had suggested a selenium redistribution in this context. To verify this hypothesis, an experimental study was designed. Temporary occlusion of the superior mesenteric artery was performed in 18 male adult Wistar rats using clamping for 0, 10, and 20 min. Hemodynamic and biochemical data were assessed before clamping and 20 min after release of the mesenteric blood flow. After release, mean arterial pressure decreased, plasma lactate increased, and erythrocyte glutathione peroxidase decreased. Plasma and erythrocyte selenium did not change; however, a slight decrease in plasma selenium was observed when related to hematocrit (to take into account the fluid balance). Erythrocyte-reduced glutathione did not change. In contrast, liver and kidney selenium increased, whereas reduced glutathione decreased in kidney, but not in liver after 20 min of clamping as compared to the sham-operated group. These results suggest that, after temporary intestinal ischemia, the changes in selenium and reduced glutathione observed in blood and tissues, like liver or kidney, could be related to a redistribution pattern in selenium metabolism during shock injury. 相似文献
997.
Pamela Paparu Thomas Dubois Danny Coyne Altus Viljoen 《Biocontrol Science and Technology》2009,19(6):639-655
The burrowing nematode (Radopholus similis (Cobb) Thorne) and the banana weevil (Cosmopolites sordidus Germar, Coleoptera: Curculionidae) are major pests of banana (Musa spp.) in the Lake Victoria basin region of Uganda. Among biological options to control the two pests is the use of non-pathogenic Fusarium oxysporum Schltdl.: Fries endophytes of banana. We investigated the ability of endophytic F. oxysporum isolates Emb2.4o and V5w2 to control the banana weevil and the burrowing nematode, alone and in combination. Plant colonization by the endophytes was determined by inoculating their chemical-resistant mutants separately and in combination, onto banana roots. Plant growth promotion was determined by measuring plant height, girth, number of live roots and fresh root weight at harvest, and control of the nematode and weevil was determined by challenging endophyte-inoculated plants with the pests 8 weeks after endophyte inoculation. Endophytic root colonization was highest in plants inoculated with both endophytes, compared with those inoculated with only one of the endophytes. Root colonization was better for isolate V5w2 than Emb2.4o. Dually inoculated plants showed a significant increase in height, girth, fresh root weight and number of functional roots following nematode challenge. Nematode numbers in roots were reduced 12 weeks after challenge of 8-week-old endophyte-inoculated plants. Significant reductions in weevil damage were observed in the rhizome periphery, inner and outer rhizomes, compared with endophyte non-inoculated controls. We conclude that dual inoculation of bananas with endophytic isolates Emb2.4o and V5w2 increases root colonization by the endophytes, reduces nematode numbers and weevil damage, and enhances plant growth in the presence of nematode infestation. 相似文献
998.
999.
1000.
Mark E. Polhemus Shon A. Remich Bernhards R. Ogutu John N. Waitumbi Lucas Otieno Stella Apollo James F. Cummings Kent E. Kester Christian F. Ockenhouse Ann Stewart Opokua Ofori-Anyinam Isabelle Ramboer Conor P. Cahill Marc Lievens Marie-Claude Dubois Marie-Ange Demoitie Amanda Leach Joe Cohen W. Ripley Ballou D. Gray Heppner Jr. 《PloS one》2009,4(7)