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31.
Angiopoietin-2 is required for postnatal angiogenesis and lymphatic patterning,and only the latter role is rescued by Angiopoietin-1 总被引:16,自引:0,他引:16
Gale NW Thurston G Hackett SF Renard R Wang Q McClain J Martin C Witte C Witte MH Jackson D Suri C Campochiaro PA Wiegand SJ Yancopoulos GD 《Developmental cell》2002,3(3):411-423
VEGF and Angiopoietin-1 requisitely collaborate during blood vessel development. While Angiopoietin-1 obligately activates its Tie2 receptor, Angiopoietin-2 can activate Tie2 on some cells, while it blocks Tie2 activation on others. Our analysis of mice lacking Angiopoietin-2 reveals that Angiopoietin-2 is dispensable for embryonic vascular development but is requisite for subsequent angiogenic remodeling. Unexpectedly, mice lacking Angiopoietin-2 also exhibit major lymphatic vessel defects. Genetic rescue with Angiopoietin-1 corrects the lymphatic, but not the angiogenesis, defects, suggesting that Angiopoietin-2 acts as a Tie2 agonist in the former setting, but as an antagonist in the latter setting. Our studies define a vascular growth factor whose primary role is in postnatal angiogenic remodeling and also demonstrate that members of the VEGF and Angiopoietin families collaborate during development of the lymphatic vasculature. 相似文献
32.
Roumiana D. Vassilevska-Ivanova Boris V. Kraptchev Ira Stancheva Maria Geneva 《Central European Journal of Biology》2013,8(5):492-498
Intergeneric cross was made between the cultivated sunflower inbred line HA89 and an accession of wild Verbesina encelioides tolerant to drought and high temperature. The line was a BC2F5 progeny. The most remarkable feature of the plants was their compact architecture due to short petiole length and also, rather specific bright-yellow inflorescences. Similar plant architecture did not exist in either the wild or the cultivated parent. For sunflower, it is considered as a favourable and potentially useful adaptive trait. The line was multi-branched of medium type branching and possessed good agronomic characteristics. The overall characteristics of HA-VERBENC line make it a useful plant material for research on wide hybridization. 相似文献