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181.
Our studies aimed at determining a loss of active heparin from the peritoneal cavity after its intraperitoneal administration (250 JU/l of dialysis fluid) in 16 patients treated because of the end-stage renal failure with intermittent peritoneal dialysis and at comparing heparin influx clearance with that of glucose. It has been shown that heparin used in this dose loses 60-70% of its activity after 20-minute equilibration of dialysis fluid in the peritoneal cavity. Heparin influx clearance is higher than that of glucose but it depends on utilization of heparin in peritoneal cavity rather than on its penetration to the blood circulation. 相似文献
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In patients suffering from Parkinson's disease (PD), we analyzed correlations between the parameters of contingent negative
variation (CNV) and data of variational pulsometry (according to the measurements of R-R ECG intervals). Studies were carried
out on 35 patients (group PD), 49 to 74 years old, with the stage of disease of 1.5 to 3.0 according to the Hoehn-Yahr international
classification. In the course of CNV recording (i.e., in the state of a certain functional loading), we observed significant
negative correlations between the integral magnitude (area) of this potential and indices of variational pulsometry (RMSSD,
SDNN, C. var, and HF) that characterize the intensity of parasympathetic (respiratory) influences on the cardiovascular system.
In the control group, such correlations were absent. We found significant correlations between the autonomic balance, CNV
magnitude, and stage of PD reflecting the level of generalization of the pathological process. In the subgroup of patients
with the PD stage 1.5 to 2.0, significant changes in the mean values of indices of parasympathetic influences during recording
of the CNV were not observed, while in another subgroup (the PD stage 2.5 to 3.0), these values increased significantly (P < 0.05 and P < 0.01). If the estimates of the PD stage were low, the CNV area demonstrated greater values (P < 0.01). The disturbance of coordination of muscle-to-muscle interactions in the PD group is, probably, an important factor
responsible for parasympathetic dysregulation and suppression of the CNV generation. We found positive correlation between
the intensity of parasympathetic influences in the course of CNV recording and the level of postural disorders (r = 0.37, P < 0.05). On the contrary, the CNV magnitude demonstrated a negative correlation with the intensity of these disorders (r = −0.36, P < 0.05), as well as with the level of postural instability (r = −0.55, P < 0.001). We hypothesize that alterations of the autonomic balance and the activity of those cerebral structures, which are
responsible for the motor readiness, result, to a significant extent, from weakening of the activity of the noradrenergic
system due to degenerative processes developing in cells of the locus coeruleus. The impairment of the latter structure, together with degeneration of neurons of the substantia nigra and a decrease in the level of nigro-striatal dopamine, underlies the pathomorphological pattern of PD.
Neirofiziologiya/Neurophysiology, Vol. 40, No. 3, pp. 242–253, May–June, 2008. 相似文献
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Dr. Benedykt Fuliński 《Development genes and evolution》1922,51(1):575-586
Ohne Zusammenfassung
Mit 2 Textabbildungen. 相似文献
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The anatomical basis for the application of neurovascular pedicled muscle transfers of the digastric and stylohyoid muscles in the treatment of velopharynx incompetence is described. The fact that the neurovascular pedicle is located in the cranial third of the muscle bellies provides the safety of the operative procedure. The muscles have to be dissected with respect to that. The direction in which the transferred muscles pull is described. The muscle transposition is combined with the classic Wardill-Kilner operation to lengthen the soft palate. The transferred muscles have to avoid scar contraction and shortening of the soft palate and to gain a muscular function of the soft palate. The clinical use is justified in rare cases as demonstrated in one case. 相似文献