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61.
62.
Donald Stone Sade 《American journal of physical anthropology》1973,38(2):537-542
Antithetical postures and movements in social displays of rhesus monkeys distinguish five moods. Movement from a high to a low position in the midsagittal plane indicates threat. Emphasis on movement in the frontal plane indicates subordinance. Movement from a low to a high position in the midsagittal plane indicates non-hostile, non-fearful approach. Oblique movements indicate a querying mood. Playfulness is indicated by emphasis on rotatory movements in the transverse plane. 相似文献
63.
J M Cheverud J Buettner-Janusch D Sade 《American journal of physical anthropology》1978,49(4):449-456
The serum transferrin locus is used to investigate the roles of the lineal effect of fission, male migration effect of fission, and genetic drift in causing intergroup genetic differentiation among the rhesus macaques of Cayo Santiago. These three mechanisms prove sufficient to explain the degrees of differentiation between the newly formed social groups A, K, and L as of July 1, 1971. The lineal effect of fission provides a baseline of intergroup differentiation which is altered by forces leading to intragroup genetic change, the male migration effect and genetic drift. The importance of population dynamics for the distribution of alleles among subgroups of a population is recognized. 相似文献
64.
Hanisch D Dittmar M Höhler T Alt KW 《Anthropologischer Anzeiger; Bericht über die biologisch-anthropologische Literatur》2004,62(1):51-60
This study aimed at analyzing the contribution of genetic and environmental factors on phenotypic variation of various traits of body composition. Subjects were 30 same-sexed pairs of twins including 20 monozygous (MZ) and 10 dizygous (DZ) pairs, aged 19-62 years. Zygosity was determined by DNA typing and morphological diagnosis. Body composition parameters (fat mass FM, lean body mass LBM, body cell mass BCM, extracellular mass ECM, total body water TBW, extracellular water ECW, and intracellular water ICW) were estimated by tetrapolar bioelectrical impedance analysis. Potential environmental factors influencing body composition (number of children, sporting activity and smoking behaviour) were determined by questionnaires. Heritabilities for traits of body composition were calculated by use of the twin method. Intraclass correlation is > 0.80 for the variation of LBM, BCM, ECM, TBW, ECW, and ICW in both MZ and DZ twins. Estimated heritability (h2) for FM, LBM, BCM, ECW, TBW, ECW, and ICW is 65%, 77%, 79%, 83%, 76%, 68%, and 82%, respectively. The h2 values for FM and LBM are consistent with those reported in other twin studies. For BCM, ECM, ECW and ICW, no comparative h2 estimates exist. Within-pair differences in body compartments do not change with increasing age in MZ and DZ twin pairs (p > 0.05). Stepwise multiple regression analyses indicate that zygosity, age, sex, number of children, sporting level and smoking behaviour do not significantly predict within-pair differences for weight, BMI, FM, LBM, TBW, ECW and ICW (each, p > 0.05). In contrast, sex and the number of children explain together 27% of observed within-pair differences for BCM. Zygosity is the only significant predictor of within-pair differences for ECM and height, explaining 20% (p = 0.008) and 36% of variance, respectively (p < 0.0001). Results indicate that genetic factors exert stronger influences on body composition than the considered environmental traits. 相似文献
65.
Cystic fibrosis mice carrying the missense mutation G551D replicate human genotype-phenotype correlations. 总被引:3,自引:0,他引:3
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S J Delaney E W Alton S N Smith D P Lunn R Farley P K Lovelock S A Thomson D A Hume D Lamb D J Porteous J R Dorin B J Wainwright 《The EMBO journal》1996,15(5):955-963
We have generated a mouse carrying the human G551D mutation in the cystic fibrosis transmembrane conductance regulator gene (CFTR) by a one-step gene targeting procedure. These mutant mice show cystic fibrosis pathology but have a reduced risk of fatal intestinal blockage compared with 'null' mutants, in keeping with the reduced incidence of meconium ileus in G551D patients. The G551D mutant mice show greatly reduced CFTR-related chloride transport, displaying activity intermediate between that of cftr(mlUNC) replacement ('null') and cftr(mlHGU) insertional (residual activity) mutants and equivalent to approximately 4% of wild-type CFTR activity. The long-term survival of these animals should provide an excellent model with which to study cystic fibrosis, and they illustrate the value of mouse models carrying relevant mutations for examining genotype-phenotype correlations. 相似文献
66.
Carole Ober Thomas J. Olivier Donald S. Sade Jon M. Schneider Jim Cheverud John Buettner-Janusch 《American journal of physical anthropology》1984,64(3):223-231
Gene frequency profiles from January 1973 to January 1977 for three polymorphic loci were examined in Cayo Santiago rhesus social groups. The effects of demographic components (i.e., births, deaths, immigrations, emigrations, and group fission and fusion) on total change in gene frequencies are assessed. Allelic frequencies at the carbonic anhydrase II, 6-phosphogluconate dehydrogenase, and transferrin loci were analyzed in four social groups. In the two groups that underwent fission and fusion during the study period, the timing of these processes was related to the largest short-term changes in gene frequences. However, immigration and emigration had the greatest effect on total change in gene frequency in all groups during the study period. The relative importance of births and deaths in producing gene frequency change varied among the social groups. These results suggest that the relative importance of the demographic components of gene frequency change in primate populations is determined by behavioral patterns and ecological conditions specific to the population considered. 相似文献
67.
Barbara R. Stucki Malcolm M. Dow Donald Stone Sade 《American journal of physical anthropology》1991,84(2):181-191
Differential rates of intrinsic growth for the population of Macaca mulatta on Cayo Santiago partitioned by social group and dominance rank of genealogies indicate that the potential for increase is not uniformly distributed throughout the population. In the period from 1973 to 1974, high-ranking genealogies were growing at a faster rate than low-ranking genealogies. Large differences in r among the social groups indicate the possible existence of demographic, genetic, or social differences between groups. A random resampling procedure was employed to assess the statistical significance of differences in the intrinsic rate of growth among the 5 natural social groups and the 3 partitions formed by, respectively, lumping members of high-, middle-, and low-ranking genealogies across several social groups. Comparisons among social groups shows that there are significant differences in the rate of growth between Group J and Group M, and between Group J and Group F for the period from 1973 to 1974. Among dominance ranks of genealogies, significant differences in r were found between the partitions of the high- and middle-ranking genealogies. These findings suggest that differential reproductive success is influenced and maintained by underlying variations in the distribution of behavioral traits in the population. 相似文献
68.
69.
Julia R. Dorin Paul Dickinson Elizabeth Emslie Alan R. Clarke Lorraine Dobbie Martin L. Hooper Stephanie Halford Brandon J. Wainwright David J. Porteous 《Transgenic research》1992,1(2):101-105
We wish to construct a mouse model for the human inherited disease cystic fibrosis. We describe here the successful targeting
in embryonal stem cells of the murine homologue (Cftr) of the cystic fibrosis transmembrane conductance regulator gene, as the first critical step towards this end. The targeting
event precisely disrupts exon 10, the site of the major mutation in patients with cystic fibrosis. The targeted cells are
pluripotent and competent to form chimaeras. 相似文献
70.
Floral colours in a world without birds and bees: the plants of Macquarie Island 总被引:1,自引:0,他引:1
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M. Shrestha K. Lunau A. Dorin B. Schulze M. Bischoff A. G. Dyer 《Plant biology (Stuttgart, Germany)》2016,18(5):842-850
We studied biotically pollinated angiosperms on Macquarie Island, a remote site in the Southern Ocean with a predominately or exclusively dipteran pollinator fauna, in an effort to understand how flower colour affects community assembly. We compared a distinctive group of cream‐green Macquarie Island flowers to the flora of likely source pools of immigrants and to a continental flora from a high latitude in the northern hemisphere. We used both dipteran and hymenopteran colour models and phylogenetically informed analyses to explore the chromatic component of community assembly. The species with cream‐green flowers are very restricted in colour space models of both fly vision and bee vision and represent a distinct group that plays a very minor role in other communities. It is unlikely that such a community could form through random immigration from continental source pools. Our findings suggest that fly pollination has imposed a strong ecological filter on Macquarie Island, favouring floral colours that are rare in continental floras. This is one of the strongest demonstrations that plant–pollinator interactions play an important role in plant community assembly. Future work exploring colour choices by dipteran flower visitors would be valuable. 相似文献