全文获取类型
收费全文 | 49319篇 |
免费 | 3513篇 |
国内免费 | 19篇 |
专业分类
52851篇 |
出版年
2024年 | 54篇 |
2023年 | 182篇 |
2022年 | 579篇 |
2021年 | 960篇 |
2020年 | 596篇 |
2019年 | 708篇 |
2018年 | 1081篇 |
2017年 | 965篇 |
2016年 | 1568篇 |
2015年 | 2439篇 |
2014年 | 2786篇 |
2013年 | 3134篇 |
2012年 | 4119篇 |
2011年 | 3965篇 |
2010年 | 2499篇 |
2009年 | 2287篇 |
2008年 | 3153篇 |
2007年 | 3029篇 |
2006年 | 2635篇 |
2005年 | 2442篇 |
2004年 | 2229篇 |
2003年 | 1934篇 |
2002年 | 1678篇 |
2001年 | 1319篇 |
2000年 | 1248篇 |
1999年 | 1006篇 |
1998年 | 410篇 |
1997年 | 351篇 |
1996年 | 251篇 |
1995年 | 218篇 |
1994年 | 212篇 |
1993年 | 174篇 |
1992年 | 333篇 |
1991年 | 305篇 |
1990年 | 269篇 |
1989年 | 230篇 |
1988年 | 178篇 |
1987年 | 163篇 |
1986年 | 133篇 |
1985年 | 112篇 |
1984年 | 81篇 |
1983年 | 85篇 |
1982年 | 64篇 |
1981年 | 53篇 |
1980年 | 54篇 |
1979年 | 69篇 |
1978年 | 51篇 |
1977年 | 50篇 |
1975年 | 43篇 |
1974年 | 64篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
51.
52.
Ho Jun Kim Seulggie Choi Kyuwoong Kim Hyungjun Park Kyae-Hyung Kim 《Chronobiology international》2020,37(2):272-280
ABSTRACTBackground: The disruption of circadian rhythm has been found to associate with obesity in vivo and in vitro. Sleep duration, eating habits, total feeding time, and nightshift work can also affect circadian rhythms. This study investigated the association between misalignment of circadian rhythm and obesity in Korean men, using a cross-sectional database.Methods: This study used data from the Korean National Health and Nutrition Examination Survey (KNHANES), whose study population was 3,658 men aged 18 to 60 years. General and abdominal obesity was defined as a body mass index (BMI) ≥ 25 kg/m2 and waist circumference ≥ 90 cm, respectively. Circadian rhythm factors were determined with a self-report questionnaire and included breakfast frequency, sleep duration, and work time. Frequency of breakfast was divided into regular breakfast (five to seven times a week) and irregular breakfast (less than five times a week). Sleep duration was divided into less than 7 hours, 7–9 hours, and over 9 hours. Working time was defined as day/evening, night shift, and other type. The adjusted odds ratios (aORs) and 95% confidence intervals (CIs) for general and abdominal obesity were calculated using multivariable logistic regression according to the number of factors that disturb the circadian rhythm.Results: Participants with 1 (aOR 1.34, 95% Cl 1.10–1.61) and ≥2 (aOR 1.62, 95% Cl 1.29–2.05) factors disturbing circadian rhythms were associated with elevated risk for general obesity. Similarly, those with 1 (aOR 1.33, 95% Cl 1.09–1.63) and ≥2 (aOR 1.70, 95% Cl 1.32–2.20) factors had elevated risk for abdominal obesity.Conclusions: Factors disturbing the circadian rhythm were associated with general and abdominal obesity. Additional studies are needed, and associations with metabolic diseases should be investigated. 相似文献
53.
54.
55.
56.
The purpose of this review is to provide an overview of the effects of adenovirus and influenza virus infections on obesity in various experimental models. We reviewed studies that were conducted within the past 10 years and were related to virus infection and obesity prevalence. Here, we discuss a different causal relationship between adenovirus and influenza infections with obesity. Adenovirus infection can cause obesity, whereas obesity can be a risk factor for increasing influenza virus infection and increases the risk of morbidity and mortality. The prevalence of obesity due to adenovirus infections may be due to an increase in glucose uptake and reduction in lipolysis caused by an increase in corticosterone secretion. Adenovirus infections may lead to increases in appetite by decreasing norepinephrine and leptin levels and also cause immune dysfunction. The relationship between obesity and influenza virus infection could be summarized by the following features: decreases in memory T-cell functionality and interferon (IFN)-α, IFN-β, and IFN-γ mRNA expression, increases in viral titer and infiltration, and impaired dendritic cell function in obese individuals. Moreover, leptin resistance may play an important role in increasing influenza virus infections in obese individuals. In conclusion, prevention of adenovirus infections could be a good approach for reducing obesity prevalence, and prevention of obesity could reduce influenza virus infections from the point of view of viral infections and obesity. 相似文献
57.
58.
J Chae M J Kim J H Goo S Collier D Gubb J Charlton P N Adler W J Park 《Development (Cambridge, England)》1999,126(23):5421-5429
The tissue polarity genes control the polarity of hairs, bristles and ommatidia in the adult epidermis of Drosophila. We report here the identification of a new tissue polarity gene named starry night (stan). Mutations in this essential gene alter the polarity of cuticular structures in all regions of the adult body. The detailed polarity phenotype of stan on the wing suggested that it is most likely a component of the frizzled (fz) pathway. Consistent with this hypothesis, stan appears to be downstream of and required for fz function. We molecularly cloned stan and found that it encodes a huge protocadherin containing nine cadherin motifs, four EGF-like motifs, two laminin G motifs, and seven transmembrane domains. This suggests that Stan functions in signal reception, perhaps together with Fz. 相似文献
59.
60.