全文获取类型
收费全文 | 1145篇 |
免费 | 46篇 |
国内免费 | 1篇 |
出版年
2023年 | 8篇 |
2022年 | 21篇 |
2021年 | 32篇 |
2020年 | 22篇 |
2019年 | 23篇 |
2018年 | 20篇 |
2017年 | 20篇 |
2016年 | 27篇 |
2015年 | 68篇 |
2014年 | 50篇 |
2013年 | 78篇 |
2012年 | 122篇 |
2011年 | 104篇 |
2010年 | 45篇 |
2009年 | 59篇 |
2008年 | 77篇 |
2007年 | 72篇 |
2006年 | 55篇 |
2005年 | 55篇 |
2004年 | 65篇 |
2003年 | 47篇 |
2002年 | 42篇 |
2001年 | 6篇 |
2000年 | 5篇 |
1999年 | 13篇 |
1998年 | 5篇 |
1997年 | 3篇 |
1996年 | 8篇 |
1995年 | 1篇 |
1994年 | 3篇 |
1993年 | 1篇 |
1992年 | 2篇 |
1991年 | 5篇 |
1990年 | 3篇 |
1989年 | 1篇 |
1988年 | 6篇 |
1987年 | 2篇 |
1986年 | 1篇 |
1985年 | 2篇 |
1984年 | 1篇 |
1983年 | 2篇 |
1982年 | 2篇 |
1981年 | 3篇 |
1980年 | 2篇 |
1979年 | 1篇 |
1976年 | 1篇 |
1974年 | 1篇 |
排序方式: 共有1192条查询结果,搜索用时 31 毫秒
181.
Dimitrios Tsikas Jrg Sandmann Frank-Mathias Gutzki Jürgen C. Frlich 《Journal of chromatography. B, Analytical technologies in the biomedical and life sciences》1999,729(1-2)
Various methods suited for the measurement of nitrate require its reduction to nitrite by cadmium under acidic or alkaline conditions. NG-Nitroarginine analogs have been shown to interfere with the measurement of nitrate by such assays. In the present work we show by gas chromatography−mass spectrometry that under alkaline reduction conditions the S-nitroso compounds S-nitrosoglutathione and S-nitrosohomocysteine but not S-nitroso-N-acetylcysteine and S-nitroso-N-acetylpenicillamine can considerably contribute to nitrate and thus interfere with its measurement. Our results suggest that S-nitroso compounds may interfere with the measurement of nitrate in methods requiring cadmium-catalyzed reduction of nitrate to nitrite. 相似文献
182.
Dimitrios Tsikas Frank-Mathias Gutzki Jrg Sandmann Edzard Schwedhelm Jürgen C. Frlich 《Journal of chromatography. B, Analytical technologies in the biomedical and life sciences》1999,731(2):139
Gas chromatography–mass spectrometry (GC–MS) of nitrite as its pentafluorobenzyl derivative in the negative-ion chemical ionization mode is a useful analytical tool to quantify accurately and sensitively nitrite and nitrate after its reduction to nitrite in various biological fluids. In the present study we demonstrate the utility of GC–tandem MS to quantify nitrate in human plasma and urine. Our present results verify human plasma and urine levels of nitrite and nitrate measured previously by GC–MS. 相似文献
183.
184.
Differential Expression of miR‐4520a Associated With Pyrin Mutations in Familial Mediterranean Fever (FMF)
下载免费PDF全文
![点击此处可从《Journal of cellular physiology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Helen Latsoudis Mir‐Farzin Mashreghi Joachim R. Grün Hyun‐Dong Chang Bruno Stuhlmüller Argyro Repa Irini Gergiannaki Eleni Kabouraki George S. Vlachos Thomas Häupl Andreas Radbruch Prodromos Sidiropoulos Kimon Doukoumetzidis Dimitris Kardassis Timothy B. Niewold Dimitrios T. Boumpas George N. Goulielmos 《Journal of cellular physiology》2017,232(6):1326-1336
185.
Eleni Timotheadou Konstantine T. Kalogeras Georgia-Angeliki Koliou Ralph M. Wirtz Flora Zagouri Angelos Koutras Elke Veltrup Christos Christodoulou George Pentheroudakis Aris Tsiftsoglou Pavlos Papakostas Gerasimos Aravantinos Vasilios Venizelos Dimitrios Pectasides Paris Kosmidis Charisios Karanikiotis Christos Markopoulos Helen Gogas George Fountzilas 《Translational oncology》2017,10(4):589-598
186.
Several viruses have been associated with the development of inflammatory arthritis, including the hepatitis viruses (hepatitis
B virus and hepatitis C virus), HIV, the parvovirus B19, the human T-cell lymphotropic virus-I, and the alphaviruses. Here,
we review the epidemiology, the pathophysiological mechanisms, the pertinent clinical and laboratory findings as well as the
principles of therapy of the most common virus-associated arthritides. We believe that the knowledge of these key diagnostic
and therapeutic features of virus-associated arthritides is important for the rheumatologist of the 21st century. 相似文献
187.
Subjects with metabolic syndrome–a constellation of cardiovascular risk factors of which central obesity and insulin resistance
are the most characteristic–are at increased risk for developing diabetes mellitus and cardiovascular disease. In these subjects,
abdominal adipose tissue is a source of inflammatory cytokines such as tumor necrosis factor-alpha, known to promote insulin
resistance. The presence of inflammatory cytokines together with the well-documented increased risk for cardiovascular diseases
in patients with inflammatory arthritides and systemic lupus erythematosus has prompted studies to examine the prevalence
of the metabolic syndrome in an effort to identify subjects at risk in addition to that conferred by traditional cardiovascular
risk factors. These studies have documented a high prevalence of metabolic syndrome which correlates with disease activity
and markers of atherosclerosis. The correlation of inflammatory disease activity with metabolic syndrome provides additional
evidence for a link between inflammation and metabolic disturbances/vascular morbidity. 相似文献
188.
It is increasingly recognized that programmed cell death includes not only apoptosis and autophagy, but also other types of nonapoptotic cell death, such as paraptosis, which are all characterized by distinct morphological features. Our findings indicate that all three types of programmed cell death occur in the ovarian nurse cell cluster during late vitellogenesis (formation of the egg yolk) of Bombyx mori (Lepidoptera), whereas middle vitellogenesis is exclusively characterized by the presence of a nonapoptotic type of cell death, known as paraptosis. During middle vitellogenesis, nurse cells exhibit clearly cytoplasmic vacuolization, as revealed by ultrastructural examination performed through conventional light and transmission electron microscopy, while no signs of apoptotic or autophagic features are detectable. Moreover, nurse cells of developmental stages 7, 8 and 9 contain autophagic compartments, as well as apoptotic characteristics, such as condensed chromatin, fragmented DNA and activated caspases, as revealed by in vitro assays. We propose that paraptosis precedes both apoptosis and autophagy during vitellogenesis, since its initial activation is detectable during middle vitellogenesis, whereas no apoptotic nor autophagic features are observed. In contrast, at the late stages of Bombyx mori oogenesis, paraptosis, autophagy and apoptosis operate synergistically, resulting in a more efficient elimination of the degenerated nurse cells. 相似文献
189.
Fotopoulou T Iliodromitis EK Koufaki M Tsotinis A Zoga A Gizas V Pyriochou A Papapetropoulos A Andreadou I Kremastinos DT 《Bioorganic & medicinal chemistry》2008,16(8):4523-4531
Ischemic preconditioning (IPC) constitutes an endogenous protective mechanism in which one or more brief periods of myocardial ischemia and reperfusion render the myocardium resistant to a subsequent more-sustained ischemic insult. Pharmacological preconditioning represents an ideal alternative of IPC. We now describe the design and synthesis of indole, quinoline, and purine systems with an attached pharmacophoric nitrate ester group. The indole and quinoline derivatives 4 and 5 possess structural features of the nitrate containing K(ATP) channel openers. Purine analogues 11 and 12, substituted at the position 6 by a piperidine moiety and at position 9 by an alkyl nitrate, could combine the effects of the nitrate containing K(ATP) channel openers and those of adenosine. Compound 13 bears the nicotinamide moiety of nicorandil instead of nitrate ester. Compounds 4, 5, and 11 reduced infarction and the levels of malondialdehyde (MDA) at reperfusion in anesthetized rabbits. Compounds 12 and 13 did not significantly reduce the infarct size. Analogues 4 and 5 increased cGMP and MDA during ischemia, while combined analogue 4 and mitoK(ATP) blocker 5-hydroxydecanoic acid (5-HD) abrogated this benefit suggesting an action through mitoK(ATP) channel opening. Treatment with derivative 11 combined with 5-HD as well as treatment with 11 and adenosine receptor blocker 8-(p-sulfophenyl)theophylline (SPT) did not abrogate cardioprotection. Compound 11 is a lead molecule for the synthesis of novel analogues possessing a dual mode of action through cGMP-mitoK(ATP) channel opening-free radicals and through adenosine receptors. 相似文献
190.
Dionyssiou D Annacontini L Armenio A Demiri E 《Plastic and reconstructive surgery》2008,121(6):2176; author reply 2176-2176; author reply 2177