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11.
dos Santos Rocha PB de Castro Amorim A de Sousa AF do Monte SJ da Mata Sousa LC do Nascimento Nogueira N Neto JM do Nascimento Marreiro D 《Biological trace element research》2011,143(2):603-611
Research has investigated the participation of zinc transport proteins and metallothionein in the metabolism of this mineral.
However, studies about the genetic expression of these proteins in obese patients are scarce. The study determined the expression
of zinc transporter protein codifying genes (ZnT-1, Zip-1 and Zip-3) and of metallothionein in 55 obese women, aged between
20 and 56 years. The assessment of body composition was carried out using anthropometric measurements and bioelectrical impedance.
Zinc intake was obtained by recording diet over a 3-day period, and the nutritional analysis was carried out using NutWin
software version 1.5. The plasmatic and erythrocytary zinc were analyzed by atomic absorption spectrophotometry (λ = 213. 9 nm). The determination of mRNA expression of the zinc transporter proteins and metallothionein was carried out using
blood, using the RT-PCR method. The mean values of body mass index were 37.9 ± 5.5 kg/m2. The average intake of zinc was 9.4 ± 2.3 mg/day. The analysis of the zinc plasma concentrations showed values of 58.4 ± 10.9 μg/dL.
The mean values of zinc in the erythroytes were 38.7 ± 9.1 μg/g Hb. The metallothionein gene had a higher expression in the
blood, when compared to zinc transporters ZnT-1, Zip-1, and Zip-3 (p = 0.01). The study shows that there are alterations in the biochemical parameters of zinc in obese patients assessed, as
well as higher expression of the codifying gene metallothionein, when compared to the investigated zinc transporters. 相似文献
12.
Gildene Alves da Costa Dilina do Nascimento Marreiro Juliana Maria Libório Eulálio José Machado Moita Neto Amanda Castro Amorim Apolônia Maria Tavares Nogueira Semíramis Jamil Hadad do Monte Nadir do Nascimento Nogueira 《Biological trace element research》2008,126(1):15
This study evaluated nutritional status linked to zinc levels in 239 randomly selected children at crèches in Teresina, Brazil, aged 3 to 6. Blood samples were collected after fasting of 10 h. Erythrocytary zinc levels were determined through flame atomic absorption spectrophotometry. Zinc deficiency was determined as below 40 µg Zn/g Hb. Infant linear growth was evaluated measuring weight and height, and nutritional status by height/age, weight/height, and weight/age indices, expressed as Z scores, in line with the National Center for Health Statistics. The mean zinc concentration was 35.50?±?10.95 µg Zn/g Hb. Zinc distribution in the 10, 50, 75, and 90 percentiles was 24.73 µg Zn/g Hb, 35.45 µg Zn/g Hb, 40.73 µg Zn/g Hb and 52.77 µg Zn/g Hb, respectively. Based on this distribution, normal values were found only from the 75th percentile and above. Since the cutoff point adopted was 40 µg Zn/g Hb, the prevalence of zinc deficiency was 74.3%. As for growth profile, 8.4% were chronically malnourished, although the statistical association between linear impairment and nutritional status regarding zinc was insignificant. The study revealed that an important segment of the infant population was mineral deficient; however, the degree of deficiency did not influence growth profiles. 相似文献
13.
Zinc nutritional status in obese children and adolescents 总被引:4,自引:0,他引:4
Studies in animals and humans have corroborated that zinc (Zn) metabolism is altered in obesity. The present work intends
to evaluate the Zn nutritional status in obese children and adolescents by the determination of some biochemical parameters
and analyses of the diets. The investigation was carried out in a group of obese children and adolescents (n=23) and compared to a control group (n=21), both between 7 and 14 yr of age. A software analyzed diet information from 3-d food records. Body composition was evaluated
by body mass index, bioelectrical impedance, and skinfold measurements. Zinc nutritional status was evaluated by Zn determination
in plasma, erythrocyte, and 24-h urine, by atomic absorption spectrophotometry (γ=213.9 nm). Diets consumed by both groups
had marginal concentrations of zinc. Zinc concentrations in plasma and erythrocytes were significantly lower in the obese
group. Urinary zinc excretion was significantly higher in the same group. The results allowed one to conclude that zinc nutritional
status in obese individuals is altered. 相似文献
14.
Jennifer Beatriz Silva Morais Juliana Soares Severo Loanne Rocha dos Santos Stéfany Rodrigues de Sousa Melo Raisa de Oliveira Santos Ana Raquel Soares de Oliveira Kyria Jayanne Clímaco Cruz Dilina do Nascimento Marreiro 《Biological trace element research》2017,176(1):20-26
Adipose tissue is considered an endocrine organ that promotes excessive production of reactive oxygen species when in excess, thus contributing to lipid peroxidation. Magnesium deficiency contributes to the development of oxidative stress in obese individuals, as this mineral plays a role as an antioxidant, participates as a cofactor of several enzymes, maintains cell membrane stability and mitigates the effects of oxidative stress. The objective of this review is to bring together updated information on the participation of magnesium in the oxidative stress present in obesity. We conducted a search of articles published in the PubMed, SciELO and LILACS databases, using the keywords ‘magnesium’, ‘oxidative stress’, ‘malondialdehyde’, ‘superoxide dismutase’, ‘glutathione peroxidase’, ‘reactive oxygen species’, ‘inflammation’ and ‘obesity’. The studies show that obese subjects have low serum concentrations of magnesium, as well as high concentrations of oxidative stress marker in these individuals. Furthermore, it is evident that the adequate intake of magnesium contributes to its appropriate homeostasis in the body. Thus, this review of current research can help define the need for intervention with supplementation of this mineral for the prevention and treatment of disorders associated with this chronic disease. 相似文献
15.
de Sousa Melo Stéfany Rodrigues dos Santos Loanne Rocha Morais Jennifer Beatriz Silva Cruz Kyria Jayanne Clímaco de Oliveira Ana Raquel Soares da Silva Nilmara Cunha de Sousa Gustavo Santos Payolla Tanyara Baliani Murata Gilson Bordin Silvana Henriques Gilberto Simeone do Nascimento Marreiro Dilina 《Biometals》2022,35(4):689-697
BioMetals - Some studies have demonstrated the participation of leptin in magnesium metabolism. On the other hand, there is evidence of the role of magnesium in the leptin intracellular signaling... 相似文献