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171.
Biray Avci Cigir Sezgin Baha Goker Bagca Bakiye Karci Halil Bulent Gode Sercan 《Molecular biology reports》2020,47(5):3641-3651
Molecular Biology Reports - Although there are many studies on the role of PI3K/AKT/mTOR pathway and autophagy genes in the mechanism of head and neck cancer formation and prognostic significance,... 相似文献
172.
Marcus W. McGinnis Zachary M. Parker Nicholas E. Walter Alex C. Rutkovsky Claudia Cartaya-Marin & Ece Karatan 《FEMS microbiology letters》2009,299(2):166-174
Vibrio cholerae , the causative agent of the devastating diarrheal disease cholera, can form biofilms on diverse biotic and abiotic surfaces. Biofilm formation is important for the survival of this organism both in its natural environment and in the human host. Development of V. cholerae biofilms are regulated by complex regulatory networks that respond to environmental signals. One of these signals, norspermidine, is a polyamine that enhances biofilm formation via the NspS/MbaA signaling system. In this work, we have investigated the role of the polyamine spermidine in regulating biofilm formation in V. cholerae . We show that spermidine import requires PotD1, an ortholog of the periplasmic substrate-binding protein of the spermidine transport system in Escherichia coli . We also show that deletion of the potD1 gene results in a significant increase in biofilm formation. We hypothesize that spermidine imported into the cell hinders biofilm formation. Exogenous spermidine further reduces biofilm formation in a PotD1-independent, but NspS/MbaA-dependent, manner. Our results suggest that polyamines affect biofilm formation in V. cholerae via multiple pathways involving both transport and signaling networks. 相似文献
173.
The levels of zinc, copper, iron, and manganese were measured in the hippocampus, thalamus, gyrus cinguli, hypothalamus, and
in the prefrontal, parietal, temporal, and occipital cortexes of lamb brain by flame atomic absorption spectrometry. Standard
addition method was also applied to samples and it was observed that there was no matrix interference affecting the determination
of elements interested. In the determination of Cu, a slotted tube atom trap was used to improve sensitivity. One-way analysis
of variance was used for the statistical evaluation of the results for each element. Limit of detection results for Zn, Cu,
Fe, and Mn were found to be 24, 4.5, 60, and 25 ng/mL, respectively. Region-specific differences were found for all elements
interested. Mn concentration ranging from 0.29 ± 0.04 to 0.61 ± 0.04 mg/kg was found to be the lowest in all brain regions
among the all elements interested. 相似文献
174.
Alagöz Dilek Varan Nazli Ece Toprak Ali Tükel S. Seyhan Yildirim Deniz 《The protein journal》2022,41(3):394-402
The Protein Journal - In this study, ene reductase (ER) was entrapped in polyvinyl alcohol hydrogel, adsorbed on montmorillonite and immobilized covalently on glutaraldehyde activated... 相似文献