排序方式: 共有152条查询结果,搜索用时 78 毫秒
41.
Esin Ozkuru Duygu Ates Seda Nemli Semih Erdogmus Nur Karaca Hasan Yilmaz Bulent Yagmur Canan Kartal Muzaffer Tosun Ozgul Ozdestan Semih Otles Abdullah Kahriman Bahattin Tanyolac 《Genomics》2019,111(6):1873-1881
Due to its high nutritional value, chickpea is one of the most important and cost-effective legumes for human diet. Nutrient elements, such as Cu, P, K have numerous essential functions for the human metabolism. In this study, association mapping of loci linked to the seed Cu, P and K concentrations were performed on a population consisting of 107 Cicer reticulatum and 73 Cicer arietinum individuals in four environments (two locations x two years). A total of 121,840 SNPs were genotyped across 180 individuals by GBS analysis. The association mapping between the SNP markers and the seed Cu, P, K concentrations were identified and eight SNPs were found to be significantly associated with variations in three nutrient elements in more than two environments This research suggests that association mapping is a useful methodology for the identification of loci controlling the Cu, P and K uptake in chickpea seeds for further association mapping, molecular breeding, and marker-assisted selection and plant breeding studies and provides a broader understanding of the relationship between the investigated Cicer species and the effects of environmental conditions. 相似文献
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doi: 10.1111/j.1741‐2358.2011.00480.x Effect of pre‐processing methods on bond strength between acrylic resin teeth and acrylic denture base resin Objectives: This study evaluated the effects of various pre‐processing methods on the bond strength between resin and denture teeth. Backgrounds: Debonding of acrylic resin teeth from denture base material is a problem for patients wearing complete dentures. Materials and Methods: Four experimental groups (n = 30) were investigated by subjecting tooth–resin bonding to tensile loading. Specimens were prepared and tested according to the methods of the International Standards Organization (ISO 22112:2005) using a special assembly. Four pre‐processing surface treatments of teeth were applied: (i) ST1, no treatment applied (control); (ii) ST2, wax solvent (Dewaks, Faber Kimya & Ilaç, Turkey); (iii) ST3, boiling water followed by conditioning with methyl methacrylate (MMA) monomer (Meliodent, Bayer Dental, Germany); (iv) ST4, boiling water followed by wax solvent agent and finally MMA monomer application. Bond strength test was performed using a universal testing machine. Results: All the strength values of the test groups were within clinically acceptable limits. The lowest values were from the ST1 group and the highest values were in the ST4 group. Conclusions: Wax elimination methods affected bonding strength. Application of wax solvent and MMA monomer to the ridge lap surfaces of the teeth gave the best results. In clinical practice, this application procedure may decrease the bonding failure of denture teeth. 相似文献
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Alcohol metabolism-mediated oxidative stress down-regulates hepcidin transcription and leads to increased duodenal iron transporter expression 总被引:14,自引:0,他引:14
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A key angiogenic role of monocyte chemoattractant protein-1 in hemangioendothelioma proliferation 总被引:4,自引:0,他引:4
Gordillo GM Onat D Stockinger M Roy S Atalay M Beck FM Sen CK 《American journal of physiology. Cell physiology》2004,287(4):C866-C873
Angiomatous lesions are common in infants and children. Hemangioendotheliomas (HE) represent one type of these lesions. Endothelial cell proliferation and the development of vascular/blood cell-filled spaces are inherent in the growth of HE. Therefore, understanding mechanisms that regulate the proliferation of these lesions should provide key insight into mechanisms regulating angiogenesis. A murine model was used to test the significance of monocyte chemoattractant protein (MCP)-1 in HE proliferation. EOMA cells, a cell line derived from a spontaneously arising murine HE, generate these lesions with 100% efficiency when injected subcutaneously into syngeneic mice. MCP-1 produced by EOMA cells recruit macrophages, which were shown to induce angiogenic behavior in EOMA cells by stimulating transwell migration and inducing sprout formation on type I collagen gels. When EOMA cells were injected into MCP-1/ mice, only 50% of the mice developed tumors, presumably because the low levels of MCP-1 expressed by the injected EOMA cells were enough to overcome any host deficits of this chemokine. When EOMA cells were coinjected with a neutralizing antibody to MCP-1, tumors failed to develop in any of the treated mice, including syngeneic 129P3, C57Bl/6 (wild type), and MCP-1/. These results present the first evidence that MCP-1 is required for HE proliferation and may promote the growth of these lesions by stimulating angiogenic behavior of endothelial cells. This study has produced the first in vivo evidence of a complete response for any neoplasm, specifically a vascular proliferative lesion, to anti-MCP-1 therapy in animals with intact immune systems. endothelium; vascular; macrophage; redox; angiogenesis 相似文献
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Res. Asst. Büşra Bıldır Asst. Prof. Dr. Duygu Nur Çobanoğlu Assoc. Prof. Dr. Bülent Kaya 《化学与生物多样性》2023,20(6):e202201093
Due to their distinct characteristics and possible uses in a variety of disciplines, nanoparticles have attracted a lot of attention recently. One area of interest is the synthesis of nanoparticles using natural sources such as bee pollen. The research aims to evaluate the usability of bee pollen extract-based magnesium nanoparticles (MgNPs). First, a palynological study was used to determine the plant source of bee pollen. The nanoparticle was characterized using scanning electron microscopy, energy dispersive X-ray analysis, transmission electron microscopy, X-ray diffractometry, and Fourier transform infrared spectroscopy. The results revealed cubic-shaped MgNPs with an average size range of 36–40 nm. Afterward, nanoparticles were evaluated for their antioxidant, antimicrobial, and neurotoxic properties. It was determined that the total antioxidant capacity, phenolic (TPC), flavonoid (TFC) content, DPPH radical scavenging, and antimicrobial activity of the nanoparticles were lower than pollen extract. At the same time, nanoparticles have less toxicity than bee pollen. 相似文献
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Duygu Nur Çobanoğlu Mehmet Emin Şeker İlginç Kizilpinar Temizer Ayşegül Erdoğan 《化学与生物多样性》2023,20(3):e202201124
Bee bread is a unique natural product made by bees and good for human health. It has many bioactive molecules that can treat or prevent diseases. In this study, melissopalynological methods were used to examine five bee bread samples. Major plant sources found in bee bread were Lotus spp., Trifolium spp., and Xeranthemum spp., which are from the Fabaceae and Asteraceae families. Then, the amount of phenolic compounds and major carotenoids in bee bread (BB) samples were quantified. Gallic acid, caffeic acid, quercetin, and kaempferol were found in all BB samples, with β-carotene being the most abundant carotenoid in all but BB1. In addition, the total phenolic/flavonoid content and antioxidant activities of all BB samples were determined. Total flavonoid, total phenolic, DPPH⋅, and ABTS⋅+ values were varied between 5.6–10.00 mg GAE/g DW, 1.2–4.3 mg QE/g DW, 1.2–5.5 mg TEAC/g DW, and 2.6–15.4 mg TEAC/g DW, respectively. 相似文献
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Günhan Erdem Cihan öner Ahmet M. önal Duygu Kisakürek A. Y. ögüs 《Journal of biosciences》1994,19(1):9-17
Previous studies indicate that ascorbic acid, when combined with copper or iron cleaves several viral DNA. ln this study,
we generated the ascorbate radical anion electrochemically in a simple chemical environment without the participation of a
metal ion. This solution possesses viral DNA scission activity. Ohe absence of catalytic metal ions [Fe (III) and Cu(II)]
in the incubation medium was evidenced by metal chelating agents such as desferrioxamine and EDTA. Ohe radical quenching at
high EDTA concentration was attributed to ionic strength of EDTA rather than metal chelation. Ohe effects of antioxidants,
radical scavangers, catalase, superoxide dismutase and some proteins on DNA cleavage have been tested. Cleavage may not arise
directly from ascorbate free radical but the reaction of the radical form of ascorbate with oxygen may produce the actual
reactive species. Aerobic oxidation of ascorbate itself strictly requires transition metal catalysts, however electrochemically
produced ascorbyl radical avoided the kinetic barrier that prevented direct oxidation of ascorbic acid with oxygen and eliminated
the need for the transition metal ion catalysts. 相似文献
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Mohammad Ashiqur Rahman Bhuiyan Shovo Marzia Rahman Tona Jannatul Mouah Fayza Islam Md. Helal Uddin Chowdhury Tuhin Das Arkajyoti Paul Duygu Aagündüz Md. Masudur Rahman Talha Bin Emran Raffaele Capasso Jesus Simal-Gandara 《Current issues in molecular biology》2021,43(2):434
Molineria capitulata is an ornamental plant that has traditionally been used to treat several chronic diseases. The present study was designed to examine the antioxidant, cytotoxic, thrombolytic, anti-inflammatory, and analgesic activities of a methanolic extract of M. capitulata leaves (MEMC) using both experimental and computational models. Previously established protocols were used to perform qualitative and quantitative phytochemical screening in MEMC. A computational study, including molecular docking and ADME/T analyses, was performed. The quantitative phytochemical analysis revealed the total phenolic and flavonoid contents as 148.67 and 24 mg/g, respectively. Antioxidant activity was assessed by examining the reducing power of MEMC, resulting in absorbance of 1.87 at 400 µg/mL, demonstrating a strong reduction capacity. The extract exhibited significant protection against blood clotting and showed the highest protein denaturation inhibition at 500 µg/mL. In both the acetic acid-induced writhing and formalin-induced paw-licking models, MEMC resulted in significant potential pain inhibition in mice. In the computational analysis, 4-hydroxybenzaldehyde, orcinol glucoside, curcapital, crassifogenin C, and 2,6-dimethoxy-benzoic acid displayed a strong predictive binding affinity against the respective receptors. These findings indicated that M. capitulata possesses significant pharmacological activities to an extent supported by computational studies. 相似文献
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Ozan Gurbuz Duygu Gocmen Nese Ozmen Fatih Dagdelen 《Preparative biochemistry & biotechnology》2013,43(4):263-275
The physicochemical properties of tarhana soup produced with different dough treatments, fermentation times, and preservation methods were examined. Tarhana doughs were prepared with yogurt (control) or baker's yeast (Saccharomyces cerevisiae) and fermented for 3 days. Samples were taken at 24, 48, and 72 hr. Samples were then preserved via one of four methods: sun dried, dried in the shade, vacumn dried, and frozen. Frozen samples produced lower organic acid levels after 72 hr of fermentation in both control (0.68 g/100 g) and yeast (0.61 g/100 g) applications than samples that were dried (0.94 g/100 g control samples; 0.81 g/100 g samples with yeast). Increasing fermentation time resulted in a significant effect on the formation of organic acid in the tarhana (p < .01). At 72 hr of fermentation, total acidity increased 11%, 17%, and 23% for tarhana samples vacumn-dried, sun-dried, and dried in the shade, respectively. Preservation methods also affected the moisture, ash, crude protein, total acidity, pH, salt, fat, reducing sugar levels, and the sensory assestment of tarhana soup (p < .01). Sensory characteristics were not significantly affected by baker's yeast in any of the preservation methods used (p > .01). However, sensory scores for tarhana prepared from the samples dried in a sheltered area showed a reduction in color desireablilty as the fermentation time increased. The soup prepared from frozen tarhana (72 hr fermentation, with yeast) had the highest scores with respect to color, mouth feel, flavor, and overall acceptability. Vacuum-dried samples' scores in these areas were also high in comparison to the two other drying methods. 相似文献