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Adah E. Otache Ifeyinwa L. Ezenwosu Edmund N. Ossai Elias C. Aniwada Emmanuel A. Nwobi Benjamin SC. Uzochukwu 《PLoS neglected tropical diseases》2022,16(2)
IntroductionOnchocerciasis, a neglected tropical disease of public health importance, causes chronic morbidity and severe disability that may impact on health-related quality of life (HRQoL) of the infected people. This study assessed the HRQoL and associated factors among onchocerciasis patients in southeast Nigeria.MethodsThis was a community-based cross-sectional comparative study. Using a multistage sampling technique, 340 onchocerciasis patients were selected and matched for age and gender with the healthy population in the same neighbourhood. The respondents were interviewed using the short-form-36 (SF-36) questionnaire to determine their HRQoL. WHO Disability Assessment Schedule 2.0 tool (WHODAS 2.0) was used to assess disability in persons with onchocerciasis. Means were compared with independent student t-test while Chi-square test was used to compare proportions. Also, correlation analysis and logistic regression were used in the analyses.ResultsA significantly lower proportion of people living with onchocerciasis had a good quality of life when compared with the healthy subjects (69.4% vs 93.5%, p<0.001). Also, an inverse relationship was seen between disability and quality of life in the onchocerciasis group (r = -0.647, p<0.001). Predictors of poor quality of life among respondents with onchocerciasis were: respondents aged ≥48 years (AOR = 2.5, 95% CI: 1.4–5.0), those with some disability associated with onchocerciasis (AOR = 3.33, 95%CI: 1.4–5.0) and respondents who perceived themselves as a burden to people (AOR = 10, 95%CI: 2.5–20).ConclusionOnchocerciasis impacted negatively on HRQoL of persons with onchocerciasis when compared with the healthy population. The quality of life of persons affected with onchocerciasis reduces with increasing disability. There is the need to increase community awareness on onchocerciasis to ensure early diagnosis and prompt treatment as this will reduce disability among those affected with the disease thus enhancing their HRQoL. 相似文献
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The effects of selective ibotenate lesions of the complete hippocampus (CHip), the hippocampal ventral pole (VP), or the medial prefrontal cortex (mPFC) in male rats were assessed on several measures related to energy regulation (i.e., body weight gain, food intake, body adiposity, metabolic activity, general behavioral activity, conditioned appetitive responding). The testing conditions were designed to minimize the nonspecific debilitating effects of these surgeries on intake and body weight. Rats with CHip and VP lesions exhibited significantly greater weight gain and food intake compared with controls. Furthermore, CHip-lesioned rats, but not rats with VP lesions, showed elevated metabolic activity, general activity in the dark phase of the light-dark cycle, and greater conditioned appetitive behavior, compared with control rats without these brain lesions. In contrast, rats with mPFC lesions were not different from controls on any of these measures. These results indicate that hippocampal damage interferes with energy and body weight regulation, perhaps by disrupting higher-order learning and memory processes that contribute to the control of appetitive and consummatory behavior. 相似文献
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Positive selection driving the evolution of a gene of male reproduction, Acp26Aa, of Drosophila: II. Divergence versus polymorphism 总被引:5,自引:1,他引:4
The evolution of the gene for a male ejaculatory protein, Acp26Aa, has been
shown to be driven by positive selection when nonsibling species in the
Drosophila melanogaster subgroup are compared. To know if selection has
been operating in the recent past and to understand the details of its
dynamics, we obtained DNA sequences of Acp26Aa and the nearby Acp26Ab gene
from 39 D. melanogaster chromosomes. Together with the 10 published
sequences, we analyzed 49 sequences from five populations in four
continents. The southern African population is somewhat differentiated from
all other populations, but its nucleotide diversity is lower at these two
loci. We find the following results for Acp26Aa: (1) The R: S (replacement
: silent changes) ratio is significantly higher in the between-species
comparisons than in the within-species data by the McDonald and Kreitman
test. Positive selection is probably responsible for the excess of amino
acid replacements between species. (2) However, within-species nucleotide
diversity is high. Neither the Tajima test nor the Fu and Li test indicates
a reduction in nucleotide diversity due to positive selection in the recent
past. (3) The newly derived nucleotides in D. melanogaster are at high
frequency significantly more often than predicted by the neutral
equilibrium. Since the nearby Acp26Ab gene does not show these patterns,
these observations cannot be attributed to the characteristics of this
chromosomal region. We suggest that positive selection is active, but may
be weak, for each amino acid change in the Acp26Aa gene.
相似文献
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ON TWO NEW MEMBERS OF THE VOLVOCACEÆ 总被引:1,自引:1,他引:0
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OOGENESIS AND EMBRYOGENY IN EPHEDRA DISTACHYA. 总被引:1,自引:1,他引:0